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Date of filling in this questionnaire or last update: 12/01/2022
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Cohort of Workers Exposed to Ethylene Oxide
Country
 

  • United States
Name
  Kaitlin Kelly-Reif
Institution
  National Institute for Occupational Safety and Health
Email
  omp3@cdc.gov
Website
 

  • https://www.cdc.gov/niosh/pgms/worknotify/ethyleneoxide.html
Upload files
 

Contact Principal Investigator (name)
  Please contact NIOSH by submitting the attached form
Upload files
 

Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
  Estimate the association between occupational exposure to ethylene oxide and causes of death
Study design (please select as many as appropriate)
 

  • Retrospective cohort
Comparators (please select as many as appropriate)
 

  • Internal study population
  • External study population (includes SMR/SIR studies)
Inclusion criteria
  Potential exposure to ethylene oxide through employment at one of 14 US plants producing sterilized medical supplies and spices
Enrollment
  Completed
Men at enrollment
  8,214
Women at enrollment
  10,039
Children (<18 years) at enrollment
  0
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Death certificate
Death certificate (specify)
 

  • Mortality is currently being updated though 2018
First follow-up period (provide year)
  1987
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Job-employment records
Occupational history/time frame
  Follow-up period
Occupational coding performed
  No
Types of exposure measurements
 

  • Workplace sampling
Methods for exposure assessment (please select as many as appropriate)
 

  • Data modelling
  • Job Exposure Matrix
Main categories
 

  • Other chemicals
Other chemicals | Ethylene oxide
 

  • Ethylene oxide
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Death certificates
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Death certificates
  • Medical records
  • Questionnaire, individual (self-recording or interview)
Outcome type (please select as many as appropriate)
 

  • Mortality
  • Morbidity
Diagnostic groups based on ICD10
 

  • C + D Neoplasms
C + D Neoplasms
 

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
  • Other, please state
6. Other Information
Possibility for linkage to data registries/data enrichment via data linkage
 

  • Cancer incidence
  • Mortality register