| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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Cancer Prevention Study-II
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Country
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Please provide any other information on the cohort location/s if needed
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Recruitment in all 50 US States
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Name
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Alpa Patel
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Institution
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American Cancer Society
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Email
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alpa.patel@cancer.org
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Personal website
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https://www.cancer.org/research/acs-researchers/alpa-v-patel-bio.html
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Marji McCullough
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Institution
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American Cancer Society
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Email
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marji.mccullough@cancer.org
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Personal website
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https://www.cancer.org/research/acs-researchers/marjorie-mccullough-bio.html
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Name
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Ryan Diver
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Institution
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American Cancer Society
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Email
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ryan.diver@cancer.org
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Personal website
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https://www.cancer.org/research/acs-researchers/ryan-diver-bio.html
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Website
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- https://www.cancer.org/research/population-science/cancer-prevention-and-survivorship-research-team/acs-cancer-prevention-studies.html
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Name of committee
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Emory University Institutional Review Board
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Upload files
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Or provide website
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- https://www.cancer.org/research/population-science/cancer-prevention-and-survivorship-research-team/acs-cancer-prevention-studies/cancer-prevention-questionnaires.html
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Data access policy (briefly describe)
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https://www.cancer.org/content/dam/cancer-org/research/epidemiology/cancer-prevention-study-data-access-policies.pdf
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Main aim of cohort, please briefly describe the main objectives of the cohort
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Identify factors associated with cancer risk and death in an adult US population recruited in 1982
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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- General population: National
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Comparators (please select as many as appropriate)
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- Internal study population
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Inclusion criteria
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Over 30 years of age
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 30 |
100+ |
57 |
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Age range at entry (subcohort)
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| Minimum |
Maximum |
Mean |
Please describe |
| 40 |
92 |
63 |
Nutrition Cohort: A sub-cohort of 184,194 participants in 21 states recruited in 1992/1993to capture cancer incidence and have regular follow-up surveys |
| 49 |
96 |
70 |
Lifelink Cohort: A sub-cohort of 39,200 participants who were recruited to provide a blood sample in 1998-2000 |
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Men at enrollment
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508,188
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Women at enrollment
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676,096
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Children (<18 years) at enrollment
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0
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Men at last follow-up
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143,008
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Women at last follow-up
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277,535
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Children (<18 years) at last follow-up
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0
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Comments
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The CPS-II cohort of ~1.2 million participants begun in 1982 is followed only for mortality, and had no additional updated survey information.
The Nutrition sub-cohort of ~184,000 participants begun in 1992 is followed for cancer incidence and mortality. Additional surveys were administered every 2-years from 1997-2017.
The Lifelink sub-cohort of ~39,000 collect a survey and blood sample between 1998-2000. An additional ~70,000 participants provided a mouthwash sample in 2001.
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Death certificate
- Hospital / physician diagnoses
- Use of registers (specify)
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Active (contact with participants) (specify)
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- Volunteers confirmed vital status through 1988.
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Death certificate (specify)
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- US National Death Index was used to collect fatal outcomes beginning in 1988 to present.
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Hospital / Physician diagnoses (specify)
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- Subjects in the Nutrition sub-cohort self-report cancers which are then verified by medical records
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Specify: Use of registers
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- Subjects in the Nutrition sub-cohort that self-report cancers but can not be verified by medical record are sent to their state cancer registry for verification
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First follow-up period (provide year)
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1992
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Last follow-up period (provide year)
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2017
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Number of follow-ups after baseline (provide number)
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12
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Comments
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All 1.2 million subjects are followed for mortality outcomes.
Only the 184,000 subjects in the Nutrition cohort are followed for cancer incidence and sent additional surveys. Follow-ups and participation rates provided reference the Nutrition Cohort population only.
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Other (specify)
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Specify: Other
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Blood samples
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Occupational history/time frame
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Other (specify)
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Specify: Other
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Current occupation and longest occupation at enrollment
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Occupational coding performed
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Yes
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Occupation (specify coding system used)
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- Broad occupation groupings from 1980 US Census
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Industry (specify coding system used)
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Types of exposure measurements
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- Biomarkers (see also section 5)
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Methods for exposure assessment (please select as many as appropriate)
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- GIS (other spatial methods)
- Self-report
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Main categories
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- Dusts and fibres
- Solvents
- Pesticides
- Other chemicals
- Physical agents
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Dusts and fibres | Fibres
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- Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material)
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Dusts and fibres | Inorganic dusts
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- Coal dust
- Stone (Natural or Artificial)
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Dusts and fibres | Organic dusts
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- Textile dust
- Wood dust (not specified)
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Other chemicals | Engine exhaust
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- Diesel engine exhaust
- Gasoline engine exhaust
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Other chemicals | Polycyclic aromatic hydrocarbons (PAHs)
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- Asphalt/Bitumen fumes
- Coal tar pitch
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Other chemicals | Second hand tobacco smoke at work
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- Second hand tobacco smoke at work (Environmental tobacco smoke - ETS)
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Other chemicals | Other
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Other chemicals | Other | Specify: Other
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Formaldehyde, Dyes
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Physical agents
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Comments
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General occupational exposure grid: In your work or daily life, are (were) you regularly exposed to any of the following? Asbestos, Chemicals/Acids/Solvents, Coal or Stone Dusts, Coal Tar/Pitch/Asphalt, Diesel Engine Exhaust, Dyes, Formaldehyde, Gasoline Exhaust, Pesticides/Herbicides, Textile Fibers/Dusts, Wood Dust, X-rays\Radioactive Materials.
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Questionnaire, individual (self-recording or interview)
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Death certificates
- Medical records
- Questionnaire, individual (self-recording or interview)
- Registry-based
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Registry-based
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- Cancer incidence
- Mortality register
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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C + D Neoplasms
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- Carcinoma in situ
- Leukemia
- Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
- Malignant neoplasm lung
- Mesothelioma
- Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
- Malignant neoplasm of bone and articular cartilage
- Melanoma and other malignant neoplasms of skin
- Neoplasms connective and soft tissue including nerves
- Malignant neoplasm of breast
- Malignant neoplasms, females gynecological
- Malignant neoplasms of male genital organs
- Malignant neoplasm of urinary tract and kidney
- Malignant neoplasms of eye, brain and other parts of central nervous system
- Malignant neoplasms of thyroid and other endocrine glands
- Malignant neoplasms of ill-defined, secondary and unspecified sites
- Malignant neoplasm without specification of site including excl. leukemia
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Other health related outcomes
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- Lifestyle change
- Quality of life/wellbeing
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Comments
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The entire 1982 cohort of 1.2 million is only followed for death since 1982. No additional outcomes.
The 1992 Nutrition sub-cohort is followed for cancer incidence and mortality. Additional health outcomes were self-reported on follow-up surveys.
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Specify: Other
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Mouthwash, Tumor tissue
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Biological processing
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Genetic and other lab analyses
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- Biomarkers (specify)
- Genomics / GWAS
- Metabolomics
- Other (specify)
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Specify: Biomarkers
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Bacterial and viral panels
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Specify: Other
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Oral microbiome
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Comments
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Biological samples are only available in the Lifelink Sub-cohort (blood samples) and the additional 70,000 subjects with mouthwash samples.
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| 6. Other Information |
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- Alcohol
- Anthropometry
- Demographics
- Diet
- Education
- Environmental, air pollution
- Medical history
- Personality
- Physical exercise
- Residential history
- Socioeconomic status
- Smoking
- Other (specify)
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Specify: Other
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Reproductive history, family history of cancer
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Possibility for linkage to data registries/data enrichment via data linkage
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Please describe plans that are funded or most likely to be funded
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US Medicare data has been linked to the Nutrition sub-cohort. This contains the medications and diagnoses for the majority of participants over the age of 65.
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