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Date of filling in this questionnaire or last update: 21/04/2021
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Cancer Prevention Study-3
Country
 

  • United States
Please provide any other information on the cohort location/s if needed
  Recruitment in 35 States, Puerto Rico, the District of Columbia comprising 93% of US population
Name
  Alpa Patel
Institution
  American Cancer Society
Email
  alpa.patel@cancer.org
Personal website
  https://www.cancer.org/research/acs-researchers/alpa-v-patel-bio.html
Name
  Ryan Diver
Institution
  American Cancer Socity
Email
  ryan.diver@cancer.org
Personal website
  https://www.cancer.org/research/acs-researchers/ryan-diver-bio.html
Website
 

  • https://www.cancer.org/research/cps3-cancer-prevention-study-3.html
Name of committee
  Emory University Institutional Review Board
Upload files
 

Data access policy (briefly describe)
  https://www.cancer.org/content/dam/cancer-org/research/epidemiology/cancer-prevention-study-data-access-policies.pdf
Main aim of cohort, please briefly describe the main objectives of the cohort
  Identify factors that influence the risk of cancer diagnosis and death in an adult US population recruited from 2006-2013.
Study design (please select as many as appropriate)
 

  • Prospective cohort
Source population (please select as many as appropriate)
 

  • General population: National
Comparators (please select as many as appropriate)
 

  • Internal study population
Inclusion criteria
  Ages 30-65, No personal history of cancer
Enrollment
  Completed
Age range at entry (main cohort)
 

Minimum Maximum Mean
30 65 48

Men at enrollment
  56,013
Women at enrollment
  198,682
Children (<18 years) at enrollment
  0
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Death certificate
  • Disease incidence records
  • Use of registers (specify)
Death certificate (specify)
 

  • Linkage with the US National Death Index
Disease incidence records (specify)
 

  • For participants that have moved out of our registry linkage states and self-reported cancer, we collect medical records to verify cancer diagnoses.
Specify: Use of registers
 

  • Linkage with 35 state cancer registries where recruitment occurred.
First follow-up period (provide year)
  2015
Participation at last follow-up (if known)
  73.3
Comments
  Follow-up for cancer diagnoses is ongoing and occurs every 3 years. Linkage for the 3-year period is available approximately 3 years after the 3-year period. For example, the linkage for all cancers through 2015 was available in 2018. Linkage for cancers from 2016-2018 will be available in 2021.

Follow-up for death outcomes is ongoing and currently occurs every 3-4 years, but will become more frequent as the cohort ages. Mortality data is currently available through 2014.

Survey return (participation) is not required to be included in the outcome follow-up. All subjects are linked to the cancer registries.

3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
  • Other (specify)
Specify: Other
  Blood samples
Occupational history/time frame
  Other (specify)
Specify: Other
  Current and longest occupation at enrollment, current occupation at follow-up
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • US Census Occupation Codes
Industry (specify coding system used)
 

  • US Census Industry codes
Types of exposure measurements
 

  • Biomarkers (see also section 5)
Methods for exposure assessment (please select as many as appropriate)
 

  • Self-report
Main categories
 

  • Dusts and fibres
  • Solvents
  • Pesticides
Comments
  Occupational exposures were captured at a general level. Have you ever worked in a job fore greater than 2-years that involved regular exposure to the following: direct work with young children, mostly outdoor work, frequent strenuous physical activity, long distance driving, local driving, direct exposure to pesticides, direct exposure to solvents, occupational exposure to dust, rotating shift work, night shift work, direct work with animals, airline flight attendant or pilot. Years exposed was also captured.
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Questionnaire, individual (self-recording or interview)
Specify: Biomarker
  Blood samples
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Death certificates
  • Medical records
  • Registry-based
Registry-based
 

  • Cancer incidence
  • Mortality register
Outcome type (please select as many as appropriate)
 

  • Mortality
Diagnostic groups based on ICD10
 

  • C + D Neoplasms
C + D Neoplasms
 

  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
Other health related outcomes
 

  • Lifestyle change
  • Quality of life/wellbeing
Comments
  Verification of incidence outcomes are limited to cancer. Subjects self-report many different medical conditions on each follow-up survey. All causes of death are captured.
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
Genetic and other lab analyses
 

  • Genomics / GWAS
  • Metabolomics
Comments
  Blood samples were captured for all participants and put in storage. Sub-studies are conducted that used genomics, metabolomics and other lab work.
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Personality
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking
  • Other (specify)
Specify: Environmental other
  Sun exposure, ambient light
Specify: Other
  Reproductive history, medications,
Please describe plans that are funded or most likely to be funded
  The CPS-3 cohort is planned to be followed for the next 30 years. New surveys are included every 3 years. We capture repeat information on life-style habits that may change, and add new questions on each survey.