| 1. IDENTIFICATION & BASIC DESCRIPTION |
|
Cohort name
|
| |
ECRHS - European Community Respiratory Health Survey
|
|
Country
|
| |
- Algeria
- Australia
- Austria
- Denmark
- Estonia
- France
- Germany
- Greece
- Iceland
- India
- Ireland
- Italy
- Netherlands
- New Zealand
- Norway
- Portugal
- Spain
- Sweden
- Switzerland
- United Kingdom
- United States
|
|
Name
|
| |
Debbie Jarvis
|
|
Institution
|
| |
Imperial College, London, UK
|
|
Email
|
| |
d.jarvis@imperial.ac.uk
|
|
Personal website
|
| |
http://www.imperial.ac.uk/people/d.jarvis
|
|
Website
|
| |
|
|
Name of committee
|
| |
Due to the muticentre structure of ECRHS multiple ethical committees involved
|
|
Or provide website
|
| |
|
|
Contact Principal Investigator (name)
|
| |
Debbie Jarvis
|
|
Is this cohort part of a consortium? (name consortium)
|
| |
The European Occupational Exposome and Health Cohort Consortium
|
|
Participation in pooled analyses
|
| |
- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
|
|
Main aim of cohort, please briefly describe the main objectives of the cohort
|
| |
To provide information about (change in) prevalence and incidence of respiratory disease and allergy, and to identify risk factors and beneficial factors for both development and prognosis of respiratory disease and allergy
|
|
Study design (please select as many as appropriate)
|
| |
|
|
Source population (please select as many as appropriate)
|
| |
- General population: International
|
|
Comparators (please select as many as appropriate)
|
| |
- Internal study population
|
|
Enrollment
|
| |
Ongoing
|
|
Age range at entry (main cohort)
|
| |
| Minimum |
Maximum |
Mean |
| 20 |
44 |
|
|
|
Men at enrollment
|
| |
5,000
|
|
Women at enrollment
|
| |
5,000
|
|
Children (<18 years) at enrollment
|
| |
0
|
|
Men at last follow-up
|
| |
3,400
|
|
Women at last follow-up
|
| |
3,600
|
|
Children (<18 years) at last follow-up
|
| |
0
|
|
Participation rate at enrollment (if known)
|
| |
78
|
|
Comments
|
| |
Overall 78%. Range 54–100, 48 centres.
|
| 2. OUTCOME FOLLOW-UP |
|
Type of data for outcome follow-up (please select as many as appropriate)
|
| |
- Active (contact with participants)
|
|
Active (contact with participants) (specify)
|
| |
- For a subgroup of the population clinical investigations with a focus on lung disease and allergy were performed at baseline and subsequently at two follow-ups
|
|
First follow-up period (provide year)
|
| |
2026
|
|
Participation at last follow-up (if known)
|
| |
60
|
|
Comments
|
| |
Please see flow chart in: Jarvis D. et al Prevalence of asthma-like symptoms with ageing. Thorax. 2018 Jan;73(1):37-48.
|
| 3. OCCUPATIONAL EXPOSURES |
|
Source of exposure data collected (please select as many as appropriate)
|
| |
- Questionnaire, Personal (Self-reporting or interview)
- Questionnaire, Personal (Occupational/industry modules)
- Environmental samples
|
|
Occupational history/time frame
|
| |
Lifetime
|
|
Occupational coding performed
|
| |
Yes
|
|
Occupation (specify coding system used)
|
| |
|
|
Types of exposure measurements
|
| |
- Biomarkers (see also section 5)
- Personal external sampling
|
|
Methods for exposure assessment (please select as many as appropriate)
|
| |
- Expert assessment
- Job Exposure Matrix
- Measurements (external sampling, biomarkers)
- Self-report
|
|
|
| |
|
|
Please insert reference/further information
|
| |
Lytras T, et al . Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey. Thorax. 2018 Nov;73(11):1008-1015.
|
|
|
| |
|
|
Please insert reference/further information
|
| |
Pape et al. Parental occupational exposure pre- and post-conception and development of asthma in offspring. Int J Epidemiol. 2020 Jul 14:dyaa085. doi: 10.1093/ije/dyaa085. Epub ahead of print.
|
|
|
| |
|
|
|
| |
|
|
Main categories
|
| |
- Dusts and fibres
- Pesticides
- Other chemicals
- Ergonomics, physical workload, and injury related
- Psychosocial domains
|
|
Dusts and fibres | Fibres
|
| |
|
|
Dusts and fibres | Fibres | Specify: Other
|
| |
Fulll job history - JEMs can be applied
|
|
Dusts and fibres | Inorganic dusts
|
| |
|
|
Dusts and fibres | Inorganic dusts | Specify: Other
|
| |
Fulll job history - JEMs can be applied
|
|
Dusts and fibres | Organic dusts
|
| |
- Organic dusts (not specified)
|
|
Dusts and fibres | Other
|
| |
|
|
Dusts and fibres | Other | Specify: Other
|
| |
Fulll job history - JEMs can be applied
|
|
Pesticides | Fungicides
|
| |
|
|
Pesticides | Fungicides | Specify: Other
|
| |
Fulll job history - JEMs can be applied
|
|
Other chemicals | Detergents and cleaning products
|
| |
- Cleaning products
- Detergents
|
|
Ergonomics, physical workload, and injury related
|
| |
|
|
Ergonomics, physical workload, and injury related | Specify: Other
|
| |
Fulll job history - JEMs can be applied
|
|
Psychosocial domains | Job task characteristics/organization of work
|
| |
|
|
Psychosocial domains | Job task characteristics/organization of work | Specify: Other
|
| |
Fulll job history - JEMs can be applied
|
|
Comments
|
| |
Due to the full job history exposures can be applied where JEMs are available
|
| 4. OUTCOMES EVALUATED |
|
Baseline - type of outcome data collected (select more than one if applicable)
|
| |
- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
|
|
Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
|
| |
Lung function, Skin prick test, broncial hyper reactivity
|
|
Specify: Biomarker
|
| |
IgE
|
|
Follow-up - type of outcome data collected (select more than one if applicable)
|
| |
- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
|
|
Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
|
| |
Lung function, Skin prick test, broncial hyper reactivity
|
|
Specify: Biomarker
|
| |
IgE, for some DNA and GWAS
|
|
Outcome type (please select as many as appropriate)
|
| |
|
|
Diagnostic groups based on ICD10
|
| |
- E Malnutrition and obesity
- J Respiratory disease
|
|
E Malnutrition and obesity
|
| |
|
|
J Respiratory disease
|
| |
- Acute bronchitis
- Vasomotor and allergic rhinitis
- Chronic rhinitis, nasopharyngitis and pharyngitis
- Chronic sinusitis
- Chronic Bronchitis
- Emphysema
- Chronic obstructive pulmonary disease (COPD)
- Asthma
|
|
Other health related outcomes
|
| |
- Biomarkers
- Lifestyle change
- Sickness absence
- Sleep
- Work participation
|
| 5. BIOLOGICAL SAMPLES & ANALYSIS |
|
Biological samples collected
|
| |
|
|
Specify: Other
|
| |
feces, skin
|
|
Biological processing
|
| |
|
|
Genetic and other lab analyses
|
| |
- Biomarkers (specify)
- Epigenomics
- Genomics / GWAS
- Metabolomics
|
|
Specify: Biomarkers
|
| |
IgE
|
|
Comments
|
| |
Only genetiic and other lab analysis for sub samples
|
| 6. Other Information |
|
|
| |
- Anthropometry
- Demographics
- Diet
- Education
- Environmental other (specify)
- Physical exercise
- Socioeconomic status
- Smoking
|
|
Specify: Environmental other
|
| |
Dust samples from indoor environments, information about cleaning products
|
|
Possibility for linkage to data registries/data enrichment via data linkage
|
| |
|
|
Specify: Other
|
| |
Possible to link to several registers for some centres
|