| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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EGEA
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Country
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Please provide any other information on the cohort location/s if needed
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France
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Name
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Valérie SIROUX
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Institution
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INSERM
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Email
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valerie.siroux@univ-grenoble-alpes.fr
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Phone
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+33 4 76 54 95 56
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Name
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Nicole Le Moual
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Institution
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Inserm
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Email
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nicole.lemoual@inserm.fr
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Do you want to add another Principal Investigator for occupational analyses
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- Add another Principal Investigator for occupational analyses
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Name
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Orianne Dumas
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Institution
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inserm
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Email
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orianne.dumas@inserm.fr
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Website
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- https://egeanet.vjf.inserm.fr/index.php/en/
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Name of committee
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First survey : Avis du comité d'éthique de Cochin Port Royal 17 janvier 1990, Déclaration d'intention à la DGS le 21 juin 1991 (DGS 910048) - Second survey : Avis favorable du CCPRB (comité consultatif de protection des personnes dans la recherche biomédicale) de Necker-Enfants Malades) 10 septembre 2001. "Etude de la santé respiratoire - Suivi à 10 ans (1991-2001)" (essai sans bénéfice individuel direct, 2043 sujets), Déclaration d'intention à la Direction Générale de la santé 26 février 2002 (RBM 01-11)
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Upload files
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Or provide website
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- https://egeanet.vjf.inserm.fr/index.php/en/presentation-en
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Contact Principal Investigator (name)
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Valérie Siroux
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Data access policy (briefly describe)
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Access to the data and the biological collection of the EGEA study is possible for the development of novel scientific programs. The scientific project (form) will be considered by the steering committee of the EGEA study for approval.
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Is this cohort part of a consortium? (name consortium)
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Gabriel, Escape
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Upload files
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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The overall objectives of the EGEA study are to study the genetic and environmental factors and their interactions in asthma and asthma-related phenotypes (bronchial hyperresponsivness, atopy), and to clarify the heterogeneity of the disease.
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Study design (please select as many as appropriate)
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- Prospective cohort
- Nested case-control / Case-cohort
- Other
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Specify: Other
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Family study
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Source population (please select as many as appropriate)
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- General population: National
- Hospital / patient-based
- Generation (parents-children) study
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Comparators (please select as many as appropriate)
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- Internal study population
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Inclusion criteria
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Inclusion criteria for probands were 15-64 for adults and 7-15 for children. Probands and their two parents should be born in France. Areas of residence were defined for each city.
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
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70 |
31 |
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Men at enrollment
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2120
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Women at enrollment
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993
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Children (<18 years) at enrollment
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669
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Men at last follow-up
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765
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Women at last follow-up
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793
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Children (<18 years) at last follow-up
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4
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Comments
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Participation rate at follow-up : 79%
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
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Active (contact with participants) (specify)
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- Questionnaire at follow-up
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First follow-up period (provide year)
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2003-2007
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Last follow-up period (provide year)
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2011-2013
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Number of follow-ups after baseline (provide number)
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2
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Participation at last follow-up (if known)
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79
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Job-employment records
- Job calendar
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Occupational history/time frame
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Lifetime
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Occupational coding performed
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Yes
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Occupation (specify coding system used)
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Methods for exposure assessment (please select as many as appropriate)
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- Expert assessment
- Job Exposure Matrix
- Self-report
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Please insert reference/further information
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http://cesp.vjf.inserm.fr/asthmajem/
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Specify: Job Exposure Matrix / Other
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OAsJEM
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Website
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http://oasjem.vjf.inserm.fr/index-en.htm
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Main categories
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- Dusts and fibres
- Solvents
- Pesticides
- Other chemicals
- Other (specify)
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Dusts and fibres | Organic dusts
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Other chemicals | Detergents and cleaning products
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- Cleaning products
- Detergents
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Other chemicals | Isocyanates
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Other chemicals | Phthalates
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Other chemicals | Welding fumes
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- Welding fumes, not specified
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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spirometry, BHR, skin prick tests
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Specify: Biomarker
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allergen specific IgE, cytokines ...
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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spirometry, BHR, skin prick tests, FeNO
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Specify: Biomarker
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cytokines, specific, IgE
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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- E Malnutrition and obesity
- H Disorders of the eye
- J Respiratory disease
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E Malnutrition and obesity
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E Malnutrition and obesity | Other (specify)
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diet, obesity
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H Disorders of the eye
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J Respiratory disease
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- Chronic rhinitis, nasopharyngitis and pharyngitis
- Nasal polyp
- Chronic Bronchitis
- Emphysema
- Chronic obstructive pulmonary disease (COPD)
- Asthma
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Other health related outcomes
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- Biomarkers
- Quality of life/wellbeing
- Sleep
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Specify: Other
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exhaled breath condensate
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Biological processing
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Genetic and other lab analyses
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- Biomarkers (specify)
- Epigenomics
- Genomics / GWAS
- Metabolomics
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Specify: Biomarkers
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cytokines, allergen specific IgE ...
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| 6. Other Information |
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- Alcohol
- Anthropometry
- Demographics
- Diet
- Education
- Environmental, air pollution
- Environmental other (specify)
- Medical history
- Physical exercise
- Residential history
- Socioeconomic status
- Smoking
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Specify: Environmental other
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indoor environment (cleaning products, pets, molds ...)
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Possibility for linkage to data registries/data enrichment via data linkage
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- Hospital discharge
- Medication usage
- Mortality register
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Please describe plans that are funded or most likely to be funded
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30-year follow-up?
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