| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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Workers maintaining and repairing railway rolling stock at railroad workshop (Officina Grandi Riparazioni - OGR) of Bologna
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Country
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Name
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Daniela Cervino
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Institution
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Local Health Trust of Bologna (AUSL)
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Email
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d.cervino@ausl.bologna.it
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Phone
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039 0514966369
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Alberto Franchi
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Institution
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Local Health Trust of Bologna (AUSL)
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Email
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a.franchi@ausl.bologna.it
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Phone
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039 051596860
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Riccardo Omenti
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Institution
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Local Health Trust of Bologna (AUSL)
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Email
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r.omenti@ausl.bologna.it
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Phone
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039 051 49663681
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Name of committee
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Comitato Etico Indipendente Area Vasta Emilia Centro Bologna Italy
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Contact Principal Investigator (name)
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Daniela Cervino
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Is this cohort part of a consortium? (name consortium)
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no
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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a) assessment of mortality by causes; b) analysis of mortality trends for some asbestos-related causes with respect to duration of exposure, period of employment, latency and task
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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- Industry / occupation-based
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Comparators (please select as many as appropriate)
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- Internal study population
- External study population (includes SMR/SIR studies)
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Inclusion criteria
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All workers as of 1/1/1957 (year from which the company’s documentation is available) but active on 01/01/1960 or hired after until 31/12/1995
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Exclusion criteria
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lack of any personal informatio or dead before 1960
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 14 |
70 |
30,12 |
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Men at enrollment
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3098
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Women at enrollment
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45
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Children (<18 years) at enrollment
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19
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Men at last follow-up
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3071
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Women at last follow-up
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44
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Children (<18 years) at last follow-up
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19
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Comments
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This study is investigating cause-specific mortality in the period 1960-2019 in the cohort of the workers of the OGR of Bologna, which represented the most important context in Italy for the number of rolling stock undergoing maintenance and repair, with a significant exposure to asbestos, for duration, i.e. over 20 years, and for the number of exposed subjects.
The strengths of the study are represented by the almost complete reconstruction of the workers' cohort and by the significant duration of the follow-up, over 50 years, which allowed a sufficient latency that brought out, in particular, the malignant mesotheliomas.
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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Death certificate (specify)
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- The verification of the alive status for the subjects no longer at work was made through a request to the General Register Office of the Municipality of the last known residence or, in its absence, of the place of birth. The request of the causes of death was addressed to AUSL offices that have managed the Register of Causes of Death (RENCAM) since 1986 onwards, also dealing with their coding according to the 9th or the 10th International Classification of Diseases (ICD) revision. For those who died before that year the request was addressed to the Municipalities, for the retrieval of information on the causes of death from the burial permits drawn up by the medical examiner. We considered the priimary cause of death.
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First follow-up period (provide year)
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2015
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Last follow-up period (provide year)
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2019
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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Occupational history/time frame
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Follow-up period
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Occupational coding performed
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Yes
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Types of exposure measurements
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Methods for exposure assessment (please select as many as appropriate)
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Main categories
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Dusts and fibres | Fibres
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- Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material)
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Death certificates
- Registry-based
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Registry-based
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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- J Respiratory disease
- K Hernia, colon and intestine disease
- K Diseases of peritoneum, liver
- N Kidney, renal pelvis disease
- N Male and female related disorders
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J Respiratory disease
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- Pneumoconiosis
- Other interstitial lung disease
- Other, please state
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J Respiratory disease | Other (specify)
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malignant pleural mesothelioma, lung cancer, laringeal cancer asbestosis
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K Hernia, colon and intestine disease
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K Hernia, colon and intestine disease | Other (specify)
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colon and intestine cancer
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K Diseases of peritoneum, liver
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K Diseases of peritoneum, liver | Other (specify)
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malignant peritoneal mesothelioma,
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N Kidney, renal pelvis disease
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N Kidney, renal pelvis disease | Other (specify)
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kidney cancer
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N Male and female related disorders
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N Male and female related disorders | Other (specify)
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ovarian cancer, testis cancer
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