Date of filling in this questionnaire or last update: 17/09/2020
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
Viking Genes
Country
  • United Kingdom
Please provide any other information on the cohort location/s if needed
The VIKING II cohort, part of Viking Genes, is recruiting worldwide as it is an online plus "spit-and-post" study.
Name
James Flett Wilson
Institution
University of Edinburgh
Email
jim.wilson@ed.ac.uk
Personal website
https://www.ed.ac.uk/profile/jim-wilson
Website
  • https://www.ed.ac.uk/viking
Name of committee
South East Scotland REC, NHS Lothian
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Contact Principal Investigator (name)
Prof Jim F. Wilson
Participation in pooled analyses
  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
Isolate populations with high kinship; aims to discover the genes and variants that influence the risk of common, complex diseases.
Study design (please select as many as appropriate)
  • Prospective cohort
Source population (please select as many as appropriate)
  • General population: Regional
  • Generation (parents-children) study
Comparators (please select as many as appropriate)
  • External study population (includes SMR/SIR studies)
Inclusion criteria
Aged over 16; two or more grandparents from Orkney or Shetland
Exclusion criteria
Under 16 years, one or fewer grandparents from Northern isles of Scotland
Enrollment
Ongoing
Age range at entry (main cohort)
Minimum Maximum Mean
16 none
Men at enrollment
4,000 (expected)
Women at enrollment
4,000 (expected)
Children (<18 years) at enrollment
Approx 100 (expected)
Comments
We're merging aspects of the completed ORCADES study with the completed Viking health Study Shetland, collectively "VIKING". We aim to recruit a further 4,000 volunteers with ancestry (two or more grandparents) from Orkney or the Shetland Isles in "VIKING II".
This new VIKING II recruitment will take the total number of participants in Viking Genes to 8,000
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
  • Disease incidence records
Disease incidence records (specify)
  • NHS Electronic health records, including the SMR01 (Scottish Morbidity Record) database of hospitalisation codes
Comments
The EHR dataset is updated on request. Nearly 100% of participants are linked or will be linked to these records for longitudinal follow-up.
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
  • Questionnaire, Personal (Self-reporting or interview)
Occupational history/time frame
Current, at enrollment
Occupational coding performed
No
Types of exposure measurements
  • Biomarkers (see also section 5)
Methods for exposure assessment (please select as many as appropriate)
  • Self-report
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Medical records
Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
Range of measures at enrolment inc spirometry, ECGs
Specify: Biomarker
Proteomics, metabolomics, genomics
Follow-up - type of outcome data collected (select more than one if applicable)
  • Medical records
Outcome type (please select as many as appropriate)
  • Mortality
  • Morbidity
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
  • Blood
  • Urine
Biological processing
  • DNA
Genetic and other lab analyses
  • Genomics / GWAS
  • Genomics / Other genetics (specify)
  • Metabolomics
  • Proteomics
Specify: Other genetics
Exome sequence
6. Other Information
Possibility for linkage to data registries/data enrichment via data linkage
  • Cancer incidence
  • Medication usage
  • Mortality register