| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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The SUS study
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Country
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Name
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Vivi Schlünssen
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Institution
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Aarhus University
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Email
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vs@ph.au.dk
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Phone
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+45 28992499
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Personal website
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http://au.dk/da/vs@ph
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Torben Sigsgaard
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Institution
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Aarhus University
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Email
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ts@ph.au.dk
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Personal website
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ts@ph.au.dk
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Name of committee
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The ethics committee of Aarhus County (AA-20070074)
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Upload files
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Contact Principal Investigator (name)
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Vivi Schlünssen or Torben Sigsgaard
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Is this cohort part of a consortium? (name consortium)
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The European Occupational Exposome Mega Cohort Consortium (OMega-X)
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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The main aim of the cohort is to investigate respiratory health effect including allergy of farm dust exposure. A second aim is to identify determinants for farm dust exposure
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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- Industry / occupation-based
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Comparators (please select as many as appropriate)
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- Internal study population
- External comparison of workers with other exposure
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Inclusion criteria
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Farming students identified during their second stay at the farming schools in Denmark during the period February 1992 to February 1994.
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 17 |
49 |
19 |
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Men at enrollment
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1,734
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Women at enrollment
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232
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Men at last follow-up
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1,038
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Women at last follow-up
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96
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Participation rate at enrollment (if known)
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79
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Other (specify)
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Active (contact with participants) (specify)
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- Clinical examination (spirometry, BHR, skin prick test, NAL, exhaled breath condensate, blood sample)
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First follow-up period (provide year)
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1995
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Last follow-up period (provide year)
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2008
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Number of follow-ups after baseline (provide number)
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5
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Participation at last follow-up (if known)
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52
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Comments
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A yearly follow-up with questionnaires (index, parents) the first 4 years, a clinical examination of cases and a control group (Omland et al JACI 2011) after 15 years a full follow-up with clinical investigation
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Occupational/industry modules)
- Industry-based questionnaire
- Job-employment records
- Environmental samples
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Occupational history/time frame
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Lifetime
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Occupational coding performed
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Yes
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Industry (specify coding system used)
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Types of exposure measurements
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- Personal external sampling
- Workplace sampling
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Methods for exposure assessment (please select as many as appropriate)
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- Job Exposure Matrix
- Measurements (external sampling, biomarkers)
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Specify: Job Exposure Matrix / Other
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Internal JEM based on measurements, type of farming and duration of work (Bolund ACS, et al. Occup Environ Med 2015;72:707–713)
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Main categories
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- Dusts and fibres
- Biological factors
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Dusts and fibres | Organic dusts
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- Organic dusts (not specified)
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Dusts and fibres | Other
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Dusts and fibres | Other | Specify: Other
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endotoxin
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Biological factors | Bacteria
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Biological factors | Bacteria | Specify: Other
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Arche bacteria. Microbiome in bedrooms and stables (Vestergaard et at Front Microbiol. 2018 May 1;9:870. doi: 10.3389/fmicb.2018.00870
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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Spirometry, BHR, skin prick test, PEF
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Specify: Biomarker
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Specific IgE common allergens and farming allergens
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Follow-up - type of outcome data collected (select more than one if applicable)
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Specify: Biomarker
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Specific IgE common allergens and farming allergens
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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- J Respiratory disease
- L Skin, nail and hair disorders
- S Injuries
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J Respiratory disease
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- Vasomotor and allergic rhinitis
- Chronic rhinitis, nasopharyngitis and pharyngitis
- Chronic sinusitis
- Chronic Bronchitis
- Chronic obstructive pulmonary disease (COPD)
- Asthma
- Hypersensitivity pneumonitis due to organic dust
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L Skin, nail and hair disorders
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- Atopic dermatitis
- Allergic contact dermatitis
- Irritant contact dermatitis
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S Injuries
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- Injuries to the head
- Injuries to the thorax
- Injuries to the abdomen, lower back, lumbar spine and pelvis
- Injuries to the shoulder, arm and fingers
- Injuries to the hip and thigh
- Injuries to the knee and lower leg, ankle and foot
- Other, please state
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S Injuries | Other (specify)
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Self-reprted injuries the first five yesr after baseline
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Other health related outcomes
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Comments
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Spefific igE for common inhalant allergens and farming allergens (moulds, storage mites, cow, pig) (Elholm G, et al. Occup Environ Med 2018;75:139–147)
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Specify: Other
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Nasal lavage, exhaled breath condensate
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Biological processing
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Genetic and other lab analyses
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Comments
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DNA and GWSA on a subsample as participant in the GABRIEL: (Moffatt et al NEJM. 2010;363:1211-21).
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| 6. Other Information |
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- Anthropometry
- Demographics
- Education
- Medical history
- Socioeconomic status
- Smoking
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Possibility for linkage to data registries/data enrichment via data linkage
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- Birth register
- Cancer incidence
- Disease specific clinical database
- Employment status
- Hospital discharge
- Medication usage
- Migration
- Mortality register
- Other (specify)
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Specify: Other
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Environmental exposure, e.g. air pollution and drinking water quality
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Please describe plans that are funded or most likely to be funded
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No current plans
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