| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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Danish Wood Dust Cohort
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Country
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Name
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Vivi Schlünssen
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Institution
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Aarhus University
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Email
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vs@ph.au.dk
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Phone
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+45 28992499
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Personal website
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http://au.dk/da/vs@ph
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Name of committee
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Ethics Committee for Viborg County, Denmark
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Upload files
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Contact Principal Investigator (name)
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Vivi Schlünssen
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Is this cohort part of a consortium? (name consortium)
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The European Occupational Exposome Mega Cohort Consortium (OMega-X)
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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The main aim of the cohort is to investigate respiratory health effect of wood dust exposure. A second aim is to identify determinants for wood dust exposure
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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- Industry / occupation-based
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Comparators (please select as many as appropriate)
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- Internal study population
- External comparison of workers with other exposure
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Inclusion criteria
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Furniture factories in a specifieWorkers employed in the woodworking, assembly and stock departments of furniture factories in former Voborg county, Denmark
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 16 |
67 |
36 |
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Men at enrollment
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1665
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Women at enrollment
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368
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Men at last follow-up
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1137
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Women at last follow-up
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240
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Participation rate at enrollment (if known)
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88
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
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First follow-up period (provide year)
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2003-4
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Last follow-up period (provide year)
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2003-4
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Number of follow-ups after baseline (provide number)
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1
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Participation at last follow-up (if known)
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68
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Comments
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It is posible to followup the cohort in Danish registerts (e.g. ISCO codes and NACE codes for occupation, hospital diagnosis, medication)
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Occupational/industry modules)
- Industry-based questionnaire
- Environmental samples
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Occupational history/time frame
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Lifetime
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Occupational coding performed
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Yes
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Industry (specify coding system used)
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Types of exposure measurements
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- Personal external sampling
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Methods for exposure assessment (please select as many as appropriate)
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- Data modelling
- Job Exposure Matrix
- Measurements (external sampling, biomarkers)
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Specify: Job Exposure Matrix / Other
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Internal job exposure matrix based on measurements, factory size and job task. jacobsen et al Eur Respir J 2009; 33: 1268–1276
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Main categories
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- Dusts and fibres
- Solvents
- Biological factors
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Dusts and fibres | Organic dusts
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- Wood dust (not specified)
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Solvents | Aliphatic and alicyclic hydrocarbon solvents
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Solvents | Aliphatic and alicyclic hydrocarbon solvents | Specify: Other
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Turpenes
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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pre- and post shift Spirometry (all), skin prick test PEF and BHR (a subsample)
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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spirometry
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Specify: Biomarker
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Specific IgE
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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- J Respiratory disease
- L Skin, nail and hair disorders
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J Respiratory disease
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- Vasomotor and allergic rhinitis
- Chronic Bronchitis
- Chronic obstructive pulmonary disease (COPD)
- Asthma
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L Skin, nail and hair disorders
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- Atopic dermatitis
- Allergic contact dermatitis
- Irritant contact dermatitis
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Biological processing
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Genetic and other lab analyses
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- Biomarkers (specify)
- Genomics / GWAS
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Specify: Biomarkers
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Specific IgE at follow up. DNA and GWAS on a subsample (Included in the EU project GABRIEL, Moffatt et al NEJM 2010;363:1211-21)
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| 6. Other Information |
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- Anthropometry
- Demographics
- Education
- Medical history
- Socioeconomic status
- Smoking
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Possibility for linkage to data registries/data enrichment via data linkage
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- Birth register
- Cancer incidence
- Disease specific clinical database
- Employment status
- Hospital discharge
- Medication usage
- Migration
- Mortality register
- Other (specify)
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Specify: Other
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enrironmental exposure (e.g. air pollution, drinking water quality
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Please describe plans that are funded or most likely to be funded
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No current plans
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