EPHOR participating cohorts

SNOW – Swedish National Cohort on Work and Health

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Date of filling in this questionnaire or last update: 21/09/2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   SNOW - Swedish National Cohort on Work and Health Country   Sweden Please provide any other information on the cohort location/s if needed   Nationwide Name   Jenny Selander Institution   Institute of Environmental Medicine, Karolinska Institutet Email   Jenny.Selander@ki.se Phone   +46 8 524 800 29 Name of committee   Regional ethical committé in Stockholm Contact Principal Investigator (name)   Jenny Selander Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Study design (please select as many as appropriate)   Prospective cohort Source population (please select as many as appropriate)   General population: National Comparators (please select as many as appropriate)   External comparison of workers with other exposure Inclusion criteria   All residents in Sweden born between 1930 and 1990 Enrollment   Ongoing Age range at entry (main cohort)   Minimum Maximum Mean 16 40 Men at enrollment   2500000 Women at enrollment   2500000 Men at last follow-up   2500000 Women at last follow-up   2500000 Participation rate at enrollment (if known)   100 Comments   Registry based cohort of all women and men born between 1930 and 1990 that are occupationally active. The cohort is also connected by personal identification number with tree sub cohorts where physical measurements and lifestyle factors are available.The cohort have been collected and is under data management. 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Death certificate Disease incidence records Hospital / physician diagnoses Use of registers (specify) Death certificate (specify)   Cause of death register Disease incidence records (specify)   National patient registers Hospital / Physician diagnoses (specify)   National patient registers First follow-up period (provide year)   1970 Last follow-up period (provide year)   2020 Number of follow-ups after baseline (provide number)   every year. Participation at last follow-up (if known)   100 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Job-employment records Registry-based Occupational history/time frame   Lifetime Occupational coding performed   Yes Occupation (specify coding system used)   FOB80, FOB85/90, SSYK96 (ISCO-88), SSYK12 (ISCO-08) Types of exposure measurements   Biomarkers (see also section 5) Methods for exposure assessment (please select as many as appropriate)   Job Exposure Matrix   Other Specify: Job Exposure Matrix / Other   SWEJEM Main categories   Dusts and fibres Solvents Pesticides Metals and metal oxides Other chemicals Biological factors Physical agents Ergonomics, physical workload, and injury related Psychosocial domains Organisation of work including working time Dusts and fibres | Fibres   Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material) Dusts and fibres | Inorganic dusts   Cement Inorganic dusts, not specified Quartz (quartz or crystalline silica containing dusts) Stone (Natural or Artificial) Dusts and fibres | Organic dusts   Animal dust (from living animals or hairs of animals, e.g. raw wool, furs of minks, etc.) Flour dust Leather dust Organic dusts (not specified) Textile dust Wood dust (not specified) Solvents | Aromatic hydrocarbon solvents   Benzene Metals and metal oxides   Iron (metallic iron and all compounds) Lead and all compounds Other chemicals | Oil mist   Synthetic metal processing or drilling oils or fluids Other chemicals | Polycyclic aromatic hydrocarbons (PAHs)   Asphalt/Bitumen fumes Benzo(a)pyrene Bitumen fumes Physical agents   Cold Hand-arm vibration Heat Noise Whole body vibration Ergonomics, physical workload, and injury related   Awkward work postures (e.g. kneeling/squatting, elevated arms, neck flection, back bent forward without support) Physical work load (e.g. heavy lifting of people or objects, pushing/pulling) Repetitive work movements Sedentary work Standing work Psychosocial domains | Job task characteristics/organization of work   Effort-reward imbalance (ERI) Job control, autonomy Psychological job demands Role conflict/ambiguity/clarity Social support at work from supervisors Skill use opportunities Work engagement Organisation of work including working time | Employment conditions   Size of the workplace and company 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Clinical/functional evaluation, e.g. spirometry, ECGs (specify) Death certificates Medical records Registry-based Specify: Clinical/functional evaluation, e.g. spirometry, ECGs   subsample have clinical examination Specify: Biomarker   subsample have biomarkers, blood samples Registry-based   Birth register Cancer incidence Disease specific clinical database Employment status Hospital discharge Medication usage Mortality register Migration Other Specify: Other   a lot more.... Follow-up - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Clinical/functional evaluation, e.g. spirometry, ECGs (specify) Death certificates Medical records Registry-based Specify: Clinical/functional evaluation, e.g. spirometry, ECGs   for subsample Specify: Biomarker   for subsample Registry-based   Birth register Cancer incidence Disease specific clinical database Employment status Hospital discharge Medication usage Mortality register Migration Other Specify: Other   a lot more registies Outcome type (please select as many as appropriate)   Mortality Morbidity Diagnostic groups based on ICD10   C + D Neoplasms E Endocrinological disease E Metabolism disease F Mental disorders G Disease in the nervous system H Disorders of the ear I Heart disease I Cerebrovascular diseases J Respiratory disease O+P Pregnancy and labour Other (specify) Other (specify)   can attach more outcome measures if needed C + D Neoplasms   Benign neoplasm Carcinoma in situ Leukemia Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas Malignant neoplasm lung Mesothelioma Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura Malignant neoplasm of bone and articular cartilage Melanoma and other malignant neoplasms of skin Neoplasms connective and soft tissue including nerves Malignant neoplasm of breast Malignant neoplasms, females gynecological Malignant neoplasms of male genital organs Malignant neoplasm of urinary tract and kidney Malignant neoplasms of eye, brain and other parts of central nervous system Malignant neoplasms of thyroid and other endocrine glands Malignant neoplasms of ill-defined, secondary and unspecified sites Malignant neoplasm without specification of site including excl. leukemia Other, please state E Endocrinological disease   Thyroidea Parathyroidea Diabetes mellitus Pituitary Other endocrinological disease Adrenogenital disorders Testicular dysfunction Other, please state E Metabolism disease   Disorder of amino-acid metabolism, unspecified Lactose intolerance Disorders of sphingolipid metabolism and other lipid storage disorders Disorders of glycosaminoglycan and glucoprotein metabolism metabolism Disorders of lipoprotein metabolism and other lipidaemias Hypercholesterolemia Disorders of purine and pyrimidine metabolism Disorders of porphyrin and bilirubin metabolism Disorders of mineral metabolism Cystic fibrosis Other, please state F Mental disorders   Dementia Personality and behavioural disorders Schizophrenia Mood [affective] disorders Depression Eating disorders Mental retardation Disorders of psychological development including autism and Aspergers syndrome Other mental disorder, not otherwise specified Other, please state G Disease in the nervous system   Infectious diseases of the central nervous system Non-infectious encephalitis, myelitis and encephalomyelitis Intracranial and intraspinal abscess and granuloma Systemic atrophies primarily affecting the central nervous system including Huntington's disease and Hereditary ataxia Spinal muscular atrophy and related syndromes Parkinson's disease Dystonia Alzheimer's disease Other degenerative disorders of nervous system in diseases classified elsewhere Multiple sclerosis Epilepsy Migraine Sleep disorders Facial nerve disorders Disorders of other cranial nerves Nerve root and plexus disorders Carpal tunnel syndrome Lesion of ulnar nerve Lesion of radial nerve Other mononeuropathies Polyneuropathies and other disorders of the peripheral nervous system Myasthenia gravis and other myoneural disorders Muscular dystrophy Muscular myopathy Cerebral palsy and other paralytic syndromes Toxic encephalopathy Hydrocephalus Other, please state H Disorders of the ear   Diseases of middle ear and mastoid Diseases of inner ear Other, please state I Heart disease   Rheumatic heart disease, unspecified Hypertensive diseases Angina pectoris Acute myocardial infarction Atrial septal defect Chronic ischaemic heart disease Pulmonary embolism Other pulmonary heart diseases Nonrheumatic mitral valve disorders Pulmonary valve disorders Endocarditis Myocarditis Cardiomyopathy Atrioventricular arrhythmia Heart failure Other, please state I Cerebrovascular diseases   Subarachnoid haemorrhage Intracerebral haemorrhage Cerebral infarction Stroke, not specified as haemorrhage or infarction Atherosclerosis Aneurysm and dissection Raynaud's syndrome Thromboangiitis obliterans [Buerger] Arterial embolism and thrombosis Phlebitis and thrombophlebitis Haemorrhoids Oesophageal varices Varicose veins of other sites Lymphadenitis Hypotension Other, please state J Respiratory disease   Acute upper respiratory infections of multiple and unspecified sites Influenza Viral pneumonia Bacterial pneumonia Pneumonia due to other infectious organisms, not elsewhere classified Abscess of lung and mediastinum Pyothorax Acute bronchitis Acute bronchiolitis Vasomotor and allergic rhinitis Chronic rhinitis, nasopharyngitis and pharyngitis Chronic sinusitis Nasal polyp Chronic diseases of tonsils and adenoids Diseases of vocal cords and larynx, not elsewhere classified Chronic Bronchitis Emphysema Chronic obstructive pulmonary disease (COPD) Asthma Byssinosis Bronchiectasis Pneumoconiosis Hypersensitivity pneumonitis due to organic dust Other interstitial lung disease Adult respiratory distress syndrome Pulmonary edema Pneumothorax Respiratory failure, not elsewhere classified Other, please state O+P Pregnancy and labour   Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium Eclampsia in pregnancy, labour or puerperium Excessive vomiting in pregnancy Venous complications in pregnancy Infections of genito-urinary tract in pregnancy Diabetes mellitus in pregnancy Malnutrition in pregnancy Other specified pregnancy-related conditions Complications of labour and delivery Preterm delivery Extremely low birth weight Other low birth weight Exceptionally large baby Birth trauma Congenital viral diseases Foetal death of unspecified cause Other, please state 5. BIOLOGICAL SAMPLES & ANALYSIS Biological samples collected   Blood Comments   only a subsample, that belong to the WOLF-cohort 6. Other Information   Anthropometry Demographics Education Medical history Socioeconomic status Smoking Possibility for linkage to data registries/data enrichment via data linkage   Birth register Cancer incidence Disease specific clinical database Employment status Hospital discharge Medication usage Migration Mortality register Other (specify) Please describe plans that are funded or most likely to be funded   follow-up until 2060.

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