| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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Barcelona Life Study Cohort (BiSC)
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Country
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Please provide any other information on the cohort location/s if needed
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Barcelona
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Name
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Payam Dadvand
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Institution
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Barcelona Institute for Global Health (ISGlobal)
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Email
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payam.dadvand@isglobal.org
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Personal website
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https://www.isglobal.org/en/our-team/-/profiles/18619
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Jordi Sunyer
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Institution
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Barcelona Institute for Global Health (ISGlobal)
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Email
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jordi.sunyer@isglobal.org
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Personal website
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https://www.isglobal.org/en/our-team/-/profiles/6203
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Name
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Payam Dadvand
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Institution
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Barcelona Institute for Global Health (ISGlobal)
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Email
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payam.dadvand@isglobal.org
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Website
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- https://www.projectebisc.org/en/home/
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Or provide website
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- https://www.projectebisc.org/en/bisc-project/protocols-questionnaires-informed-consent/
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Contact Principal Investigator (name)
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Jordi Sunyer/Payam Dadvand
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Is this cohort part of a consortium? (name consortium)
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ATHLETE
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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BiSC is a prospective cohort study of pregnant women, their offspring and partners in an urban population. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from foetal life until young adulthood.
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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Comparators (please select as many as appropriate)
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- Internal study population
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Inclusion criteria
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All women a) with singleton pregnancy b) aged between 18-45 years c) within weeks 11-15 of their gestation d) able to communicate in Spanish/Catalan e) resident in the city of Barcelona or Esplugues de Llobregat f) plan to give birth in one of the BISC recruiting hospitals
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Exclusion criteria
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a) use of artificial reproduction techniques for the current pregnancy, if it has applied donated oocyte or sperm b) having a severe chronic health condition that could limit the ability to communicate or attend the follow-ups (e.g. severe mental health conditions) c) having a plan to leave Barcelona city or Esplugues de Llobregat before delivery or having a plan to leave Barcelona Province after delivery (Note: If the potential participant does not know whether she will move out of Barcelona/Barcelona Metropolitan Area, she should NOT be excluded. Only having a plan to leave is an exclusion criterion.) d) Being high-risk for congenital anomalies
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Year(s) of enrollment
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Enrollment
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Ongoing
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 18 |
45 |
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Men at enrollment
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1000
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Women at enrollment
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1000
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Children (<18 years) at enrollment
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1000
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Hospital / physician diagnoses
- Use of registers (specify)
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First follow-up period (provide year)
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Ongoing (trimesters 2 & 3 of pregnancy and months 6 and 18 postnatally
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Last follow-up period (provide year)
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Ongoing
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Number of follow-ups after baseline (provide number)
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Ongoing
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
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Occupational history/time frame
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Other (specify)
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Specify: Other
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Occupational history from one month before the start of pregnancy and during pregnancy
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Occupational coding performed
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No
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Types of exposure measurements
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- Biomarkers (see also section 5)
- Personal external sampling
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Methods for exposure assessment (please select as many as appropriate)
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- Data modelling
- Other (specify)
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Specify: Other
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Personal monitoring of air pollution (NO2 and PM2.5)
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Main categories
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Main categories | Other | Specify: Other
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Air pollution
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Medical records
- Questionnaire, individual (self-recording or interview)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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Ultrasound examination of fetal growth and development, ultrasound examination of placental function, MRI of newborn brain, neuropsychological development of newborn
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Specify: Biomarker
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Hair, blood, urine, rectal and vaginal swabs, nail, placenta, cord blood
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
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Diagnostic groups based on ICD10
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- F Mental disorders
- O+P Pregnancy and labour
- Q After birth – child disorders
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F Mental disorders
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- Mood [affective] disorders
- Depression
- Eating disorders
- Disorders of psychological development including autism and Aspergers syndrome
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O+P Pregnancy and labour
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- Excessive vomiting in pregnancy
- Diabetes mellitus in pregnancy
- Complications of labour and delivery
- Preterm delivery
- Other low birth weight
- Other, please state
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O+P Pregnancy and labour | Other (specify)
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Fetal anthropometry and brain and cardiovascular development
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Q After birth – child disorders
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Q After birth – child disorders | Other (specify)
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Neurodevelopment, allergic and respiratory conditions, growth
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Other health related outcomes
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- Biomarkers
- Organ function (specify)
- Sleep
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Specify: Organ function
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Neurodevelopment
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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- Blood
- Hair
- Nails
- Urine
- Other
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Specify: Other
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Placenta, cord blood, rectal and vaginal swabs
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Biological processing
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Comments
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BiSC has collected biological samples to conduct genetics and epigenetics studies.
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| 6. Other Information |
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- Alcohol
- Anthropometry
- Demographics
- Diet
- Education
- Environmental, air pollution
- Environmental other (specify)
- Medical history
- Personality
- Physical exercise
- Residential history
- Socioeconomic status
- Smoking
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Specify: Environmental other
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Noise, greenspace, water, temperature, chemicals, cosmetic use, UV radiation, home characteristics
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Possibility for linkage to data registries/data enrichment via data linkage
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