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Date of filling in this questionnaire or last update: 19/05/2020
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Polish Mother and Child cohort (REPRO_PL)
Country
 

  • Poland
Name
  Kinga Polanska
Institution
  Nofer Institute of Occupational Medicine
Email
  kinga.polanska@imp.lodz.pl
Phone
  + 48426314569
Personal website
  www.imp.lodz.pl
Website
 

  • http://www.repropl.com/
Name of committee
  Ethical Committee of the Nofer Institute of Occupational Medicine, Łódź, Poland (Decision No. 7/2007)
Upload files
 

Or provide website
 

  • https://pubmed.ncbi.nlm.nih.gov/27152464/ or https://pubmed.ncbi.nlm.nih.gov/25940455/
Contact Principal Investigator (name)
  Kinga Polanska
Data access policy (briefly describe)
  Based on Data Transfer Agreement
Is this cohort part of a consortium? (name consortium)
  https://www.birthcohorts.net/
Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
  REPRO_PL aims at evaluation of the impact of exposure to environmental, lifestyle-related and occupational factors on pregnancy outcomes, children’s health and neurodevelopment.
Study design (please select as many as appropriate)
 

  • Prospective cohort
Source population (please select as many as appropriate)
 

  • Mother-child cohort
Comparators (please select as many as appropriate)
 

  • Internal study population
Inclusion criteria
  Single pregnancy up to 12 weeks of gestation
Exclusion criteria
  assisted conception, pregnancy complications, and chronic diseases as specified in the study protocol
Year(s) of enrollment
 

From To
2007 2011

Enrollment
  Ongoing
Age range at entry (main cohort)
 

Minimum Maximum Mean
29.2 ± 4.2

Women at enrollment
  1763
Women at last follow-up
  1634 (for the pregnancy period)
Children (<18 years) at last follow-up
  450 (at age of 7 years)
Participation rate at enrollment (if known)
  82
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Active (contact with participants)
  • Hospital / physician diagnoses
Active (contact with participants) (specify)
 

  • child health based on examination by physician: pediatrician and allergist (skin prick testing, spirometry) child neurodevelopment by psychologist
Hospital / Physician diagnoses (specify)
 

  • birth weight and gestational age based on medical records
First follow-up period (provide year)
  2009
Last follow-up period (provide year)
  2019
Number of follow-ups after baseline (provide number)
  6
Participation at last follow-up (if known)
  40
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
Occupational history/time frame
  Current, at enrollment
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • ISCO-88
Methods for exposure assessment (please select as many as appropriate)
 

  • Job Exposure Matrix
 

  • Other
Specify: Job Exposure Matrix / Other
  JEM for EDCs
Website
  https://pubmed.ncbi.nlm.nih.gov/27152464/
Main categories
 

  • Ergonomics, physical workload, and injury related
  • Psychosocial domains
  • Organisation of work including working time
Ergonomics, physical workload, and injury related
 

  • Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
  • Sedentary work
  • Standing work
Psychosocial domains | Job task characteristics/organization of work
 

  • Other (specify)
Psychosocial domains | Job task characteristics/organization of work | Specify: Other
  Work Characteristics Questionnaire
Organisation of work including working time | Working hours
 

  • Duration
Comments
  The women described three times in pregnancy their occupational activity (type of work performed, duration) and if they are exposed to the specific factors in the workplace.
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Medical records
  • Questionnaire, individual (self-recording or interview)
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Medical records
  • Questionnaire, individual (self-recording or interview)
Outcome type (please select as many as appropriate)
 

  • Morbidity
Diagnostic groups based on ICD10
 

  • E Malnutrition and obesity
  • O+P Pregnancy and labour
  • Q After birth – child disorders
E Malnutrition and obesity
 

  • Vitamin A deficiency
  • Vitamin D deficiency
  • Deficiency of vitamin E
  • Deficiency of other nutrient elements
  • Other, please state
E Malnutrition and obesity | Other (specify)
  macro and micronutrients based on FFQ and assesment of vitamin A,E,D and Zn, Cu, Se in blood
O+P Pregnancy and labour
 

  • Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
  • Venous complications in pregnancy
  • Diabetes mellitus in pregnancy
  • Malnutrition in pregnancy
  • Other specified pregnancy-related conditions
  • Complications of labour and delivery
  • Preterm delivery
  • Extremely low birth weight
  • Other low birth weight
  • Exceptionally large baby
Q After birth – child disorders
 

  • Other, please state
Q After birth – child disorders | Other (specify)
  child neurodevelopment, respiratory health, allergy and asthma
Other health related outcomes
 

  • Biomarkers
  • Sickness absence
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
  • Hair
  • Urine
  • Other
Specify: Other
  saliva
Biological processing
 

  • DNA
Genetic and other lab analyses
 

  • Biomarkers (specify)
  • Epigenomics
Specify: Biomarkers
  PAH and phthalates in urine, Pb, Zn, Cu, Se in plasma and Hg in hair
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking
Specify: Environmental other
  phthalates, heavy metals
Please describe plans that are funded or most likely to be funded
  The next follow-up of the children is planned at age of 13-14 years