Date of filling in this questionnaire or last update: 24/10/2021
Cohort name
  PERSIAN Birth Cohort

  • Iran

Please provide any other information on the cohort location/s if needed
  It is conducted in five cities in Iran
  Roya Kelishadi
  Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences
Personal website -kelishadi


Name of committee
  Isfahan University of Medical Sciences
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Contact Principal Investigator (name)
  Roya Kelishadi
Data access policy (briefly describe)
  Data will be shared after receiving proposals and obtaining the confirmation of the Steering committee
Is this cohort part of a consortium? (name consortium)
  Birth Cohort Consortium of Asia (Bicca)
Participation in pooled analyses

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).

Main aim of cohort, please briefly describe the main objectives of the cohort
  The main objective of the PERSIAN Birth Cohort is to evaluate the effects of socio-economic characteristics, lifestyle, diet and environmental exposures, as well as genetic and epigenetic factors, on • different periods of periconception and early life • pregnancy complications and outcomes • mother and child mental and physical health and well-being • child neurodevelopment • early- and late-onset of risk factors for chronic NCDs. We also aim to assess how early life stimuli and exposures over the life course would lead to epigenetic variations
Study design (please select as many as appropriate)

  • Prospective cohort

Source population (please select as many as appropriate)

  • Mother-child cohort

Comparators (please select as many as appropriate)

  • Internal study population
  • External study population (includes SMR/SIR studies)

Inclusion criteria
  Iranian pregnant mothers and their newborns
Exclusion criteria
  Non compliance of participants
Men at enrollment
Women at enrollment
Children (<18 years) at enrollment
  Information will be completed after data management.
Type of data for outcome follow-up (please select as many as appropriate)

  • Active (contact with participants)

First follow-up period (provide year)
Source of exposure data collected (please select as many as appropriate)

  • Questionnaire, Personal (Self-reporting or interview)

Occupational history/time frame
Occupational coding performed
Types of exposure measurements

  • Biomarkers (see also section 5)
  • Personal external sampling

Methods for exposure assessment (please select as many as appropriate)

  • Data modelling
  • GIS (other spatial methods)
  • Expert assessment
  • Measurements (external sampling, biomarkers)
  • Self-report

Main categories

  • Solvents
  • Pesticides
  • Metals and metal oxides
  • Other chemicals
  • Psychosocial domains
  • Organisation of work including working time

Solvents | Aliphatic and alicyclic hydrocarbon solvents

  • Gasoline
  • Solvent naphtha

Solvents | Aromatic hydrocarbon solvents

  • Benzene

Solvents | Chlorinated hydrocarbon solvents

  • Methylene chloride
  • Vinyl chloride

Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated

  • Alcohols
  • Esters

Pesticides | Fungicides

  • Other (specify)

Pesticides | Insecticides

  • Chlorinated, not specified
  • DDT

Metals and metal oxides

  • Aluminium
  • Arsenic all types
  • Cadmium and all compounds
  • Chromium (metallic chromium, Cr(iii), Cr(vi) and all compounds)
  • Lead and all compounds

Other chemicals | Carbon monoxide

  • Carbon monoxide

Other chemicals | Detergents and cleaning products

  • Cleaning products
  • Detergents

Other chemicals | Engine exhaust

  • Diesel engine exhaust
  • Gasoline engine exhaust

Other chemicals | Oil mist

  • Synthetic metal processing or drilling oils or fluids

Other chemicals | Phthalates

  • Phthalates

Psychosocial domains | Job task characteristics/organization of work

  • Job control, autonomy
  • Psychological job demands
  • Social support at work from supervisors
  • Work engagement

Organisation of work including working time | Employment conditions

  • Contract duration
  • Job insecurity

Organisation of work including working time | Shift work

  • Night (permanent or rotating)
  • Rotating (not night)
  • Regular/variable

Organisation of work including working time | Working hours

  • Duration

Baseline - type of outcome data collected (select more than one if applicable)

  • Biomarker (specify)

Follow-up - type of outcome data collected (select more than one if applicable)

  • Biomarker (specify)
  • Questionnaire, individual (self-recording or interview)

Outcome type (please select as many as appropriate)

  • Mortality
  • Morbidity
  • Disability

Diagnostic groups based on ICD10

  • A Bacterial infectious disease, type of microorganisms*
  • D Diseases of blood and blood-forming organs excl. leukemia
  • E Endocrinological disease
  • E Malnutrition and obesity
  • E Metabolism disease
  • F Mental disorders
  • G Disease in the nervous system
  • O+P Pregnancy and labour
  • Q After birth – child disorders
  • S Injuries

A Bacterial infectious disease, type of microorganisms*

  • Brucella
  • Salmonella
  • Shigella

D Diseases of blood and blood-forming organs excl. leukemia

  • Aplastic and other anemias
  • Anaemia, unspecified
  • Coagulation defects

E Endocrinological disease

  • Thyroidea
  • Diabetes mellitus
  • Other endocrinological disease

E Malnutrition and obesity

  • Obesity

E Metabolism disease

  • Other, please state

F Mental disorders

  • Dementia
  • Personality and behavioural disorders
  • Schizophrenia
  • Mood [affective] disorders
  • Depression
  • Eating disorders
  • Mental retardation
  • Disorders of psychological development including autism and Aspergers syndrome
  • Other mental disorder, not otherwise specified
  • Other, please state

G Disease in the nervous system

  • Infectious diseases of the central nervous system
  • Other degenerative disorders of nervous system in diseases classified elsewhere
  • Multiple sclerosis
  • Epilepsy
  • Hydrocephalus

O+P Pregnancy and labour

  • Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
  • Eclampsia in pregnancy, labour or puerperium
  • Excessive vomiting in pregnancy
  • Venous complications in pregnancy
  • Infections of genito-urinary tract in pregnancy
  • Diabetes mellitus in pregnancy
  • Malnutrition in pregnancy
  • Other specified pregnancy-related conditions
  • Complications of labour and delivery
  • Preterm delivery
  • Extremely low birth weight
  • Other low birth weight
  • Exceptionally large baby
  • Birth trauma
  • Congenital viral diseases
  • Foetal death of unspecified cause
  • Other, please state

Q After birth – child disorders

  • Congenital malformations of the nervous system incl. the brain
  • Congenital malformations of the circulatory system
  • Congenital malformations of the respiratory system
  • Cleft lip and cleft palate
  • Congenital malformations of digestive system
  • Congenital malformations of genital organs
  • Congenital malformations of the urinary system
  • Congenital malformations and deformations of the musculoskeletal system
  • Down's syndrome
  • Turner's syndrome
  • Klinefelter's syndrome
  • Other, please state

S Injuries

  • Injuries to the head
  • Injuries to the thorax
  • Injuries to the abdomen, lower back, lumbar spine and pelvis
  • Injuries to the shoulder, arm and fingers
  • Injuries to the hip and thigh
  • Injuries to the knee and lower leg, ankle and foot
  • Other, please state

Other health related outcomes

  • Biomarkers
  • Lifestyle change
  • Organ function (specify)
  • Quality of life/wellbeing
  • Sleep
  • Work participation

Biological samples collected

  • Blood
  • Hair
  • Nails
  • Urine
  • Other

Specify: Other
  Breast milk
Biological processing

  • DNA

Genetic and other lab analyses

  • Biomarkers (specify)
  • Epigenomics
  • Metabolomics

6. Other Information

  • Alcohol
  • Anthropometry
  • Diet
  • Education
  • Environmental, air pollution
  • Medical history
  • Personality
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking

Possibility for linkage to data registries/data enrichment via data linkage

  • Birth register
  • Disease specific clinical database
  • Employment status