Date of filling in this questionnaire or last update: 12/01/2022
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Born in Bradford
Country
 

  • United Kingdom

Please provide any other information on the cohort location/s if needed
  Bradford, UK
Name
  John Wright
Institution
  Bradford Teaching Hospitals NHS Foundation Trust
Email
  john.wright@bthft.nhs.uk
Phone
  01274 36 4279
Personal website
  https://borninbradford.nhs.uk/
Website
 

  • https://borninbradford.nhs.uk/

Name of committee
  Bradford Research Ethics Committee
Upload files
 

Or provide website
 

  • https://borninbradford.nhs.uk/research/

Data access policy (briefly describe)
  Requests for existing data and biological samples will be reviewed, prioritised and authorised by the BiB Executive Group. The Investigator should complete an outline proforma available on the Born in Bradford website (borninbradford.nhs.uk) and submit to: borninbradford@bthft.nhs.uk
Main aim of cohort, please briefly describe the main objectives of the cohort
  The cohort was established in 2007 with the broad aims to: describe health and ill health within a multi-ethnic (largely bi-ethnic) economically deprived population; identify modifiable causal pathways that promote well-being or contribute to ill health; develop, design and evaluate interventions to promote health; provide a model for integrating operational, epidemiological and evaluative research into practice within the National Health Service and other health-related systems; and build and strengthen local research capacity in Bradford.
Study design (please select as many as appropriate)
 

  • Prospective cohort

Source population (please select as many as appropriate)
 

  • Mother-child cohort

Inclusion criteria
  All women planning to give birth at the BRI will be eligible for recruitment, regardless of parity.
Exclusion criteria
  The only exclusion criterion for recruitment of a woman will be if she plans to move away from Bradford before the birth.
Enrollment
  Completed
Age range at entry (subcohort)
 

Minimum Maximum Mean Please describe
14 49 27

Men at enrollment
  3448
Women at enrollment
  12453
Children (<18 years) at enrollment
  13858
Men at last follow-up
  On-going
Women at last follow-up
  On-going
Children (<18 years) at last follow-up
  On-going
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Active (contact with participants)
  • Disease incidence records
  • Hospital / physician diagnoses

Comments
  Please refer to our study documents on the Born in Bradford webpage (https://borninbradford.nhs.uk/research/study-documents/) for information on data collected and all follow-ups.
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
  • Breath samples
  • Environmental samples

Occupational history/time frame
  Current, at enrollment
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • NS-SEC

Types of exposure measurements
 

  • Biomarkers (see also section 5)
  • Personal external sampling

Methods for exposure assessment (please select as many as appropriate)
 

  • Data modelling
  • GIS (other spatial methods)
  • Measurements (external sampling, biomarkers)
  • Self-report

4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Medical records
  • Questionnaire, individual (self-recording or interview)

Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/
Specify: Biomarker
  Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Medical records
  • Questionnaire, individual (self-recording or interview)

Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/
Specify: Biomarker
  Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/
Outcome type (please select as many as appropriate)
 

  • Mortality
  • Morbidity
  • Disability

Comments
  Born in Bradford collects and has data linkage to a wide range of data, including hospital and GP records. Please refer to the Born in Bradford data dictionary for detailed information: https://borninbradford.github.io/datadict/
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
  • Urine

Biological processing
 

  • DNA

Genetic and other lab analyses
 

  • Biomarkers (specify)
  • Epigenomics
  • Genomics / GWAS
  • Genomics / Other genetics (specify)
  • Metabolomics

Specify: Biomarkers
  Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/
Specify: Other genetics
  Exome sequencing
Comments
  Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Medical history
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking

Possibility for linkage to data registries/data enrichment via data linkage
 

  • Birth register
  • Hospital discharge
  • Medication usage
  • Mortality register