| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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CONSTANCES
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Country
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Please provide any other information on the cohort location/s if needed
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Main regions of France
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Name
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Marie Zins
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Institution
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INSERM and Paris University
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Email
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marie.zins@inserm.fr
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Phone
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+33 6 83850131
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Name
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Marcel Goldberg
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Institution
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INSERM and Paris University
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Email
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marcel.goldberg@inserm.fr
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Phone
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+33 687172997
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Website
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Name of committee
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CNIL and INSERM IRB
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Contact Principal Investigator (name)
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Pr Marie Zins
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Data access policy (briefly describe)
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Formal application, review by the Scientific Committee,
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Is this cohort part of a consortium? (name consortium)
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EPHOR, OMEGA-NET, IDEAR, LONGITOOLS
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Main aim of cohort, please briefly describe the main objectives of the cohort
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The CONSTANCES general-purpose cohort is intended to serve as an epidemiological research infrastructure accessible to the epidemiologic research community with a focus on occupational factors and on chronic diseases and ageing.
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Source population (please select as many as appropriate)
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- General population: National
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Comparators (please select as many as appropriate)
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- Internal study population
- External study population (includes SMR/SIR studies)
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Inclusion criteria
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Randomly selected sample of French adults aged 18-69 years at inception
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Exclusion criteria
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None
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
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69 |
46 |
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Men at enrollment
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99000
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Women at enrollment
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116000
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Children (<18 years) at enrollment
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0
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Men at last follow-up
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98800
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Women at last follow-up
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115700
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Children (<18 years) at last follow-up
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0
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Participation rate at enrollment (if known)
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7.5
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Death certificate
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Active (contact with participants) (specify)
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- Annual self-questionnaire
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Death certificate (specify)
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- Annual linkage to the "Système national des données de santé" national which includes date and cause of death
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First follow-up period (provide year)
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2013
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Last follow-up period (provide year)
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2020
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Number of follow-ups after baseline (provide number)
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8 for the participants included in 2012, 7 for those included in 2013, etc.
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Participation at last follow-up (if known)
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75
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Job-employment records
- Job calendar
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Occupational history/time frame
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Lifetime
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Occupational coding performed
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Yes
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Occupation (specify coding system used)
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Industry (specify coding system used)
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Methods for exposure assessment (please select as many as appropriate)
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- Job Exposure Matrix
- Self-report
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Specify: Job Exposure Matrix / Other
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JEM-Constances
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Main categories
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- Dusts and fibres
- Solvents
- Pesticides
- Metals and metal oxides
- Other chemicals
- Biological factors
- Physical agents
- Ergonomics, physical workload, and injury related
- Psychosocial domains
- Organisation of work including working time
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Dusts and fibres | Fibres
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- Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material)
- Glass wool
- Rock wool
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Dusts and fibres | Inorganic dusts
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- Cement
- Coal dust
- Inorganic dusts, not specified
- Stone (Natural or Artificial)
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Dusts and fibres | Organic dusts
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- Textile dust
- Wood dust (not specified)
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Solvents | Aliphatic and alicyclic hydrocarbon solvents
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Solvents | Aromatic hydrocarbon solvents
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Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated
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Pesticides | Other
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Pesticides | Other | Specify: Other
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Pesticides not specified
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Metals and metal oxides
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- Copper
- Iron (metallic iron and all compounds)
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Other chemicals | Detergents and cleaning products
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- Cleaning products
- Detergents
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Other chemicals | Engine exhaust
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- Diesel engine exhaust
- Gasoline engine exhaust
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Other chemicals | Oil mist
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- Synthetic metal processing or drilling oils or fluids
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Other chemicals | Welding fumes
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- Welding fumes, not specified
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Physical agents
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- Cold
- Hand-arm vibration
- Heat
- Noise
- Radiation
- Whole body vibration
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Ergonomics, physical workload, and injury related
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- Awkward work postures (e.g. kneeling/squatting, elevated arms, neck flection, back bent forward without support)
- Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
- Repetitive work movements
- Sedentary work
- Standing work
- Work with video display units (VDU)
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Psychosocial domains | Job task characteristics/organization of work
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- Effort-reward imbalance (ERI)
- Social support at work from supervisors
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Organisation of work including working time | Employment conditions
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- Contract duration
- Low pay
- Size of the workplace and company
- Work contract type (i.e. permanent, term-contract, subcontract, temporary)
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Organisation of work including working time | Shift work
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- Night (permanent or rotating)
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Organisation of work including working time | Working hours
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Medical records
- Questionnaire, individual (self-recording or interview)
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Specify: Biomarker
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Blood sugar level, lipid work-up, liver function tests, blood creatinine levels, complete blood cell counts, urine tests
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Death certificates
- Medical records
- Questionnaire, individual (self-recording or interview)
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Specify: Biomarker
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Blood sugar level, lipid work-up, liver function tests, blood creatinine levels, complete blood cell counts, urine tests
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Outcome type (please select as many as appropriate)
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- Mortality
- Morbidity
- Disability
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Diagnostic groups based on ICD10
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- A Bacterial infectious disease, type of microorganisms*
- B Viral infections, type of microorganisms*
- B99 Other and unspecified infectious diseases, type of microorganisms*
- C + D Neoplasms
- D Diseases of blood and blood-forming organs excl. leukemia
- E Endocrinological disease
- E Malnutrition and obesity
- E Metabolism disease
- F Mental disorders
- G Disease in the nervous system
- H Disorders of the eye
- H Disorders of the ear
- I Heart disease
- I Cerebrovascular diseases
- J Respiratory disease
- K Diseases of oral cavity, salivary glands and jaws
- K Diseases of oesophagus, stomach, duodenum and appendix
- K Hernia, colon and intestine disease
- K Diseases of peritoneum, liver
- L Skin, nail and hair disorders
- M Arthritis, arthrosis, systemic connective disorders, spine disorders
- M Disorders of muscles, bones, synovialis, bursa, cartilage
- N Kidney, renal pelvis disease
- N Male and female related disorders
- O+P Pregnancy and labour
- S Injuries
- Other (specify)
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A Bacterial infectious disease, type of microorganisms*
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- Anasakis
- Bartonella
- Bordetella pertussis
- Borrelia
- Brucella
- Campylobacter
- Coxiella
- Clostridium tetani
- Clostridium difficile
- Francisella tularensis
- Helicobacter pylori
- Legionella
- Leishmania
- Leptospira
- Mycobacterium bovis
- Mycobacterium tuberculosis
- Neisseria gonorrhoeae
- Neisseria meningitides
- Pseudomonas aeruginosa
- Rickettsia
- Salmonella
- Shigella
- Staphylococcus
- Streptococcus
- Toxocara
- Toxoplasma gondii
- Trachomatis
- Treponema pallidum
- Trichomonas vaginalis
- Other bacterial infections, please state
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B Viral infections, type of microorganisms
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- Cytomegalovirus
- Hantavirus
- Hepatitis (A,B,C,E)
- HIV virus
- Human herpes virus
- Human papilloma virus
- Human T-lymphotrophic virus
- Influenza virus
- Measles virus
- Monkey pox virus
- Mumps virus
- Parvovirus
- Rhinovirus
- Rubella virus
- Tick-borne encephalitis virus
- Varicella zoster virus
- West Nile virus
- SARS coronavirus
- Other viral infections, please state
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B99 Other and unspecified infectious diseases, type of microorganisms
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- Giardia lamblia
- Chlamydia
- Other infections, please state
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C + D Neoplasms
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- Benign neoplasm
- Carcinoma in situ
- Leukemia
- Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
- Malignant neoplasm lung
- Mesothelioma
- Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
- Malignant neoplasm of bone and articular cartilage
- Melanoma and other malignant neoplasms of skin
- Neoplasms connective and soft tissue including nerves
- Malignant neoplasm of breast
- Malignant neoplasms, females gynecological
- Malignant neoplasms of male genital organs
- Malignant neoplasm of urinary tract and kidney
- Malignant neoplasms of eye, brain and other parts of central nervous system
- Malignant neoplasms of thyroid and other endocrine glands
- Malignant neoplasms of ill-defined, secondary and unspecified sites
- Malignant neoplasm without specification of site including excl. leukemia
- Other, please state
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D Diseases of blood and blood-forming organs excl. leukemia
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- Diseases of spleen
- Polycythaemia vera
- Myelodysplastic syndromes
- Essential (haemorrhagic) thrombocythaemia
- Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
- Iron deficiency
- Vitamin deficiency
- Aplastic and other anemias
- Acquired haemolytic anaemia
- Enzyme disorders including Thalassaemia and Sickle-cell disorders
- Other anaemias
- Anaemia, unspecified
- Coagulation defects
- Purpura and other haemorrhagic conditions
- Other diseases of blood and blood-forming organs
- Immunodeficiency
- Sarcoidosis
- Other, please state
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E Endocrinological disease
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- Thyroidea
- Parathyroidea
- Diabetes mellitus
- Pituitary
- Other endocrinological disease
- Adrenogenital disorders
- Testicular dysfunction
- Other, please state
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E Metabolism disease
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- Disorder of amino-acid metabolism, unspecified
- Lactose intolerance
- Disorders of sphingolipid metabolism and other lipid storage disorders
- Disorders of glycosaminoglycan and glucoprotein metabolism metabolism
- Disorders of lipoprotein metabolism and other lipidaemias
- Hypercholesterolemia
- Disorders of purine and pyrimidine metabolism
- Disorders of porphyrin and bilirubin metabolism
- Disorders of mineral metabolism
- Cystic fibrosis
- Other, please state
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F Mental disorders
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- Dementia
- Personality and behavioural disorders
- Schizophrenia
- Mood [affective] disorders
- Depression
- Eating disorders
- Mental retardation
- Disorders of psychological development including autism and Aspergers syndrome
- Other mental disorder, not otherwise specified
- Other, please state
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G Disease in the nervous system
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- Infectious diseases of the central nervous system
- Non-infectious encephalitis, myelitis and encephalomyelitis
- Intracranial and intraspinal abscess and granuloma
- Systemic atrophies primarily affecting the central nervous system including
- Huntington's disease and Hereditary ataxia
- Spinal muscular atrophy and related syndromes
- Parkinson's disease
- Dystonia
- Alzheimer's disease
- Other degenerative disorders of nervous system in diseases classified elsewhere
- Multiple sclerosis
- Epilepsy
- Migraine
- Sleep disorders
- Facial nerve disorders
- Disorders of other cranial nerves
- Nerve root and plexus disorders
- Carpal tunnel syndrome
- Lesion of ulnar nerve
- Lesion of radial nerve
- Other mononeuropathies
- Polyneuropathies and other disorders of the peripheral nervous system
- Myasthenia gravis and other myoneural disorders
- Muscular dystrophy
- Muscular myopathy
- Cerebral palsy and other paralytic syndromes
- Toxic encephalopathy
- Hydrocephalus
- Other, please state
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H Disorders of the eye
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- Disorders of eyelid
- Xanthelasma of eyelid
- Disorders of lachrymal system
- Disorders of orbit
- Conjunctivitis
- Disorders of sclera
- Disorders of cornea
- Iridocyclitis
- Senile cataract
- Other cataract
- Other disorders of lens
- Retinal disorders
- Glaucoma
- Other disorders of vitreous body and globe in diseases classified elsewhere
- Disorders of optic nerve and visual pathways
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Visual disturbances and blindness
- Other, please state
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H Disorders of the ear
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- Diseases of middle ear and mastoid
- Diseases of inner ear
- Other, please state
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I Heart disease
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- Rheumatic heart disease, unspecified
- Hypertensive diseases
- Angina pectoris
- Acute myocardial infarction
- Atrial septal defect
- Chronic ischaemic heart disease
- Pulmonary embolism
- Other pulmonary heart diseases
- Nonrheumatic mitral valve disorders
- Pulmonary valve disorders
- Endocarditis
- Myocarditis
- Cardiomyopathy
- Atrioventricular arrhythmia
- Heart failure
- Other, please state
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I Cerebrovascular diseases
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- Subarachnoid haemorrhage
- Intracerebral haemorrhage
- Cerebral infarction
- Stroke, not specified as haemorrhage or infarction
- Atherosclerosis
- Aneurysm and dissection
- Raynaud's syndrome
- Thromboangiitis obliterans [Buerger]
- Arterial embolism and thrombosis
- Phlebitis and thrombophlebitis
- Haemorrhoids
- Oesophageal varices
- Varicose veins of other sites
- Lymphadenitis
- Hypotension
- Other, please state
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J Respiratory disease
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- Acute upper respiratory infections of multiple and unspecified sites
- Influenza
- Viral pneumonia
- Bacterial pneumonia
- Pneumonia due to other infectious organisms, not elsewhere classified
- Abscess of lung and mediastinum
- Pyothorax
- Acute bronchitis
- Acute bronchiolitis
- Vasomotor and allergic rhinitis
- Chronic rhinitis, nasopharyngitis and pharyngitis
- Chronic sinusitis
- Nasal polyp
- Chronic diseases of tonsils and adenoids
- Diseases of vocal cords and larynx, not elsewhere classified
- Chronic Bronchitis
- Emphysema
- Chronic obstructive pulmonary disease (COPD)
- Asthma
- Byssinosis
- Bronchiectasis
- Pneumoconiosis
- Hypersensitivity pneumonitis due to organic dust
- Other interstitial lung disease
- Adult respiratory distress syndrome
- Pulmonary edema
- Pneumothorax
- Respiratory failure, not elsewhere classified
- Other, please state
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K Diseases of oral cavity, salivary glands and jaws
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- Dental caries
- Gingivitis and periodontal diseases
- Dentofacial anomalies [including malocclusion]
- Stomatitis and related lesions
- Diseases of tongue
- Other, please state
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K Diseases of oesophagus, stomach, duodenum and appendix
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- Oesophagitis
- Gastro-oesophageal reflux disease
- Other diseases of oesophagus
- Gastric ulcer
- Duodenal ulcer
- Peptic ulcer, site unspecified
- Gastrojejunal ulcer
- Gastritis and duodenitis
- Dyspepsia
- Other, please state
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K Hernia, colon and intestine disease
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- Hernia
- Crohn's disease
- Ulcerative colitis
- Other non-infective gastro-enteritis and colitis
- Vascular disorders of intestine
- Paralytic ileus and intestinal obstruction without hernia
- Diverticular disease of intestine
- Irritable bowel syndrome
- Fissure and fistula of anal and rectal regions
- Abscess of anal and rectal regions
- Intestinal malabsorption
- Other, please state
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K Diseases of peritoneum, liver
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- Peritonitis
- Alcoholic liver disease
- Toxic liver disease
- Chronic hepatitis
- Fibrosis and cirrhosis of liver
- Cholelithiasis/Cholecystitis
- Acute pancreatitis
- Other, please state
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L Skin, nail and hair disorders
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- Infections of the skin and subcutaneous tissue
- Bullous disorders
- Atopic dermatitis
- Allergic contact dermatitis
- Irritant contact dermatitis
- Dermatitis due to substances taken internally
- Pruritus
- Psoriasis/Parapsoriasis
- Urticaria
- Erythema nodosum
- Sunburn
- Nail disorders
- Alopecia areata
- Hypertrichosis
- Acne
- Vitiligo
- Other, please state
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M Arthritis, arthrosis, systemic connective disorders, spine disorders
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- Bacterial arthritis
- Reactive arthritis
- Rheumatoid arthritis
- Juvenile arthritis
- Gout
- Other arthritis
- Polyarthrosis
- Coxarthrosis
- Gonarthrosis [arthrosis of knee]
- Arthrosis of first carpometacarpal joint
- Other arthrosis
- Deformities of fingers and toes
- Deformities of limbs
- Deformities of spine including scoliosis
- Disorders of patella
- Internal derangement of knee
- Pathological dislocation and subluxation of joint
- Systemic lupus erythematosus
- Systemic sclerosis
- Polymyalgia rheumatic
- Other systemic involvement of connective tissue
- Spine disk disorders
- Lumbago with sciatica
- Low back pain
- Other, please state
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M Disorders of muscles, bones, synovialis, bursa, cartilage
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- Myositis
- Calcification and ossification of muscle
- Contracture of muscle
- Chronic crepitant synovitis of hand and wrist
- Bursitis of hand
- Olecranon bursitis
- Prepatellar bursitis
- Other bursitis
- Rotator cuff syndrome
- Bicipital tendinitis
- Calcific tendinitis of shoulder
- Impingement syndrome of shoulder
- Medial epicondylitis
- Lateral epicondylitis
- Other Synovitis and tenosynovitis
- Osteoporosis
- Osteomalacia
- Skeletal fluorosis
- Osteomyelitis - Osteonecrosis
- Chondropathies
- Other, please state
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N Kidney, renal pelvis disease
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- Glomerular diseases
- Renal tubulo-interstitial diseases
- Obstructive and reflux uropathy
- Nephropathy
- Renal failure
- Urolithiasis
- Cystitis
- Urethral stricture
- Other, please state
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N Male and female related disorders
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- Hyperplasia of prostate
- Other disorders of prostate
- Torsion of testis
- Orchitis and epididymitis
- Male infertility
- Disorders of penis
- Other disorders of male genital organs
- Benign mammary dysplasia
- Salpingitis and oophoritis
- Inflammatory disease of uterus
- Inflammatory disease of cervix uteri
- Female pelvic inflammatory disease, unspecified
- Inflammation of vagina and vulva
- Endometriosis
- Other disorders of female genital and reproductive organs
- Abnormal menstrual cycle
- Female infertility
- In vitro fertilisation
- Spontaneous abortion
- Molar pregnancy
- Elective abortion
- Other, please state
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O+P Pregnancy and labour
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- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Eclampsia in pregnancy, labour or puerperium
- Excessive vomiting in pregnancy
- Venous complications in pregnancy
- Infections of genito-urinary tract in pregnancy
- Diabetes mellitus in pregnancy
- Malnutrition in pregnancy
- Other specified pregnancy-related conditions
- Complications of labour and delivery
- Preterm delivery
- Extremely low birth weight
- Other low birth weight
- Exceptionally large baby
- Birth trauma
- Congenital viral diseases
- Foetal death of unspecified cause
- Other, please state
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S Injuries
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- Injuries to the head
- Injuries to the thorax
- Injuries to the abdomen, lower back, lumbar spine and pelvis
- Injuries to the shoulder, arm and fingers
- Injuries to the hip and thigh
- Injuries to the knee and lower leg, ankle and foot
- Other, please state
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Other health related outcomes
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- Biomarkers
- Lifestyle change
- Sickness absence
- Sleep
- Work participation
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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| 6. Other Information |
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- Alcohol
- Anthropometry
- Demographics
- Diet
- Education
- Environmental, air pollution
- Environmental other (specify)
- Medical history
- Physical exercise
- Residential history
- Socioeconomic status
- Smoking
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Specify: Environmental other
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Area deprivation index
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Possibility for linkage to data registries/data enrichment via data linkage
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- Employment status
- Hospital discharge
- Medication usage
- Mortality register
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Please describe plans that are funded or most likely to be funded
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Pesticides, light, noise, water
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