Date of filling in this questionnaire or last update: 17/04/2021
Cohort name

  • France

Please provide any other information on the cohort location/s if needed
  Main regions of France
  Marie Zins
  INSERM and Paris University
  +33 6 83850131
  Marcel Goldberg
  INSERM and Paris University
  +33 687172997


Name of committee
Contact Principal Investigator (name)
  Pr Marie Zins
Data access policy (briefly describe)
  Formal application, review by the Scientific Committee,
Is this cohort part of a consortium? (name consortium)
Main aim of cohort, please briefly describe the main objectives of the cohort
  The CONSTANCES general-purpose cohort is intended to serve as an epidemiological research infrastructure accessible to the epidemiologic research community with a focus on occupational factors and on chronic diseases and ageing.
Source population (please select as many as appropriate)

  • General population: National

Comparators (please select as many as appropriate)

  • Internal study population
  • External study population (includes SMR/SIR studies)

Inclusion criteria
  Randomly selected sample of French adults aged 18-69 years at inception
Exclusion criteria
Age range at entry (main cohort)

Minimum Maximum Mean
18 69 46

Men at enrollment
Women at enrollment
Children (<18 years) at enrollment
Men at last follow-up
Women at last follow-up
Children (<18 years) at last follow-up
Participation rate at enrollment (if known)
Type of data for outcome follow-up (please select as many as appropriate)

  • Active (contact with participants)
  • Death certificate

Active (contact with participants) (specify)

  • Annual self-questionnaire

Death certificate (specify)

  • Annual linkage to the "Système national des données de santé" national which includes date and cause of death

First follow-up period (provide year)
Last follow-up period (provide year)
Number of follow-ups after baseline (provide number)
  8 for the participants included in 2012, 7 for those included in 2013, etc.
Participation at last follow-up (if known)
Source of exposure data collected (please select as many as appropriate)

  • Questionnaire, Personal (Self-reporting or interview)
  • Job-employment records
  • Job calendar

Occupational history/time frame
Occupational coding performed
Occupation (specify coding system used)

  • French PCS 2003

Industry (specify coding system used)

  • French NAF

Methods for exposure assessment (please select as many as appropriate)

  • Job Exposure Matrix
  • Self-report


  • Other

Specify: Job Exposure Matrix / Other
Main categories

  • Dusts and fibres
  • Solvents
  • Pesticides
  • Metals and metal oxides
  • Other chemicals
  • Biological factors
  • Physical agents
  • Ergonomics, physical workload, and injury related
  • Psychosocial domains
  • Organisation of work including working time

Dusts and fibres | Fibres

  • Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material)
  • Glass wool
  • Rock wool

Dusts and fibres | Inorganic dusts

  • Cement
  • Coal dust
  • Inorganic dusts, not specified
  • Stone (Natural or Artificial)

Dusts and fibres | Organic dusts

  • Textile dust
  • Wood dust (not specified)

Solvents | Aliphatic and alicyclic hydrocarbon solvents

  • Gasoline
  • White spirit

Solvents | Aromatic hydrocarbon solvents

  • Benzene

Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated

  • Formaldehyde

Pesticides | Other

  • Other

Pesticides | Other | Specify: Other
  Pesticides not specified
Metals and metal oxides

  • Copper
  • Iron (metallic iron and all compounds)

Other chemicals | Detergents and cleaning products

  • Cleaning products
  • Detergents

Other chemicals | Engine exhaust

  • Diesel engine exhaust
  • Gasoline engine exhaust

Other chemicals | Oil mist

  • Synthetic metal processing or drilling oils or fluids

Other chemicals | Welding fumes

  • Welding fumes, not specified

Physical agents

  • Cold
  • Hand-arm vibration
  • Heat
  • Noise
  • Radiation
  • Whole body vibration

Ergonomics, physical workload, and injury related

  • Awkward work postures (e.g. kneeling/squatting, elevated arms, neck flection, back bent forward without support)
  • Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
  • Repetitive work movements
  • Sedentary work
  • Standing work
  • Work with video display units (VDU)

Psychosocial domains | Job task characteristics/organization of work

  • Effort-reward imbalance (ERI)
  • Social support at work from supervisors

Organisation of work including working time | Employment conditions

  • Contract duration
  • Low pay
  • Size of the workplace and company
  • Work contract type (i.e. permanent, term-contract, subcontract, temporary)

Organisation of work including working time | Shift work

  • Night (permanent or rotating)

Organisation of work including working time | Working hours

  • Regular/variable

Baseline - type of outcome data collected (select more than one if applicable)

  • Biomarker (specify)
  • Medical records
  • Questionnaire, individual (self-recording or interview)

Specify: Biomarker
  Blood sugar level, lipid work-up, liver function tests, blood creatinine levels, complete blood cell counts, urine tests
Follow-up - type of outcome data collected (select more than one if applicable)

  • Biomarker (specify)
  • Death certificates
  • Medical records
  • Questionnaire, individual (self-recording or interview)

Specify: Biomarker
  Blood sugar level, lipid work-up, liver function tests, blood creatinine levels, complete blood cell counts, urine tests
Outcome type (please select as many as appropriate)

  • Mortality
  • Morbidity
  • Disability

Diagnostic groups based on ICD10

  • A Bacterial infectious disease, type of microorganisms*
  • B Viral infections, type of microorganisms*
  • B99 Other and unspecified infectious diseases, type of microorganisms*
  • C + D Neoplasms
  • D Diseases of blood and blood-forming organs excl. leukemia
  • E Endocrinological disease
  • E Malnutrition and obesity
  • E Metabolism disease
  • F Mental disorders
  • G Disease in the nervous system
  • H Disorders of the eye
  • H Disorders of the ear
  • I Heart disease
  • I Cerebrovascular diseases
  • J Respiratory disease
  • K Diseases of oral cavity, salivary glands and jaws
  • K Diseases of oesophagus, stomach, duodenum and appendix
  • K Hernia, colon and intestine disease
  • K Diseases of peritoneum, liver
  • L Skin, nail and hair disorders
  • M Arthritis, arthrosis, systemic connective disorders, spine disorders
  • M Disorders of muscles, bones, synovialis, bursa, cartilage
  • N Kidney, renal pelvis disease
  • N Male and female related disorders
  • O+P Pregnancy and labour
  • S Injuries
  • Other (specify)

A Bacterial infectious disease, type of microorganisms*

  • Anasakis
  • Bartonella
  • Bordetella pertussis
  • Borrelia
  • Brucella
  • Campylobacter
  • Coxiella
  • Clostridium tetani
  • Clostridium difficile
  • Francisella tularensis
  • Helicobacter pylori
  • Legionella
  • Leishmania
  • Leptospira
  • Mycobacterium bovis
  • Mycobacterium tuberculosis
  • Neisseria gonorrhoeae
  • Neisseria meningitides
  • Pseudomonas aeruginosa
  • Rickettsia
  • Salmonella
  • Shigella
  • Staphylococcus
  • Streptococcus
  • Toxocara
  • Toxoplasma gondii
  • Trachomatis
  • Treponema pallidum
  • Trichomonas vaginalis
  • Other bacterial infections, please state

B Viral infections, type of microorganisms

  • Cytomegalovirus
  • Hantavirus
  • Hepatitis (A,B,C,E)
  • HIV virus
  • Human herpes virus
  • Human papilloma virus
  • Human T-lymphotrophic virus
  • Influenza virus
  • Measles virus
  • Monkey pox virus
  • Mumps virus
  • Parvovirus
  • Rhinovirus
  • Rubella virus
  • Tick-borne encephalitis virus
  • Varicella zoster virus
  • West Nile virus
  • SARS coronavirus
  • Other viral infections, please state

B99 Other and unspecified infectious diseases, type of microorganisms

  • Giardia lamblia
  • Chlamydia
  • Other infections, please state

C + D Neoplasms

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
  • Other, please state

D Diseases of blood and blood-forming organs excl. leukemia

  • Diseases of spleen
  • Polycythaemia vera
  • Myelodysplastic syndromes
  • Essential (haemorrhagic) thrombocythaemia
  • Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
  • Iron deficiency
  • Vitamin deficiency
  • Aplastic and other anemias
  • Acquired haemolytic anaemia
  • Enzyme disorders including Thalassaemia and Sickle-cell disorders
  • Other anaemias
  • Anaemia, unspecified
  • Coagulation defects
  • Purpura and other haemorrhagic conditions
  • Other diseases of blood and blood-forming organs
  • Immunodeficiency
  • Sarcoidosis
  • Other, please state

E Endocrinological disease

  • Thyroidea
  • Parathyroidea
  • Diabetes mellitus
  • Pituitary
  • Other endocrinological disease
  • Adrenogenital disorders
  • Testicular dysfunction
  • Other, please state

E Metabolism disease

  • Disorder of amino-acid metabolism, unspecified
  • Lactose intolerance
  • Disorders of sphingolipid metabolism and other lipid storage disorders
  • Disorders of glycosaminoglycan and glucoprotein metabolism metabolism
  • Disorders of lipoprotein metabolism and other lipidaemias
  • Hypercholesterolemia
  • Disorders of purine and pyrimidine metabolism
  • Disorders of porphyrin and bilirubin metabolism
  • Disorders of mineral metabolism
  • Cystic fibrosis
  • Other, please state

F Mental disorders

  • Dementia
  • Personality and behavioural disorders
  • Schizophrenia
  • Mood [affective] disorders
  • Depression
  • Eating disorders
  • Mental retardation
  • Disorders of psychological development including autism and Aspergers syndrome
  • Other mental disorder, not otherwise specified
  • Other, please state

G Disease in the nervous system

  • Infectious diseases of the central nervous system
  • Non-infectious encephalitis, myelitis and encephalomyelitis
  • Intracranial and intraspinal abscess and granuloma
  • Systemic atrophies primarily affecting the central nervous system including
  • Huntington's disease and Hereditary ataxia
  • Spinal muscular atrophy and related syndromes
  • Parkinson's disease
  • Dystonia
  • Alzheimer's disease
  • Other degenerative disorders of nervous system in diseases classified elsewhere
  • Multiple sclerosis
  • Epilepsy
  • Migraine
  • Sleep disorders
  • Facial nerve disorders
  • Disorders of other cranial nerves
  • Nerve root and plexus disorders
  • Carpal tunnel syndrome
  • Lesion of ulnar nerve
  • Lesion of radial nerve
  • Other mononeuropathies
  • Polyneuropathies and other disorders of the peripheral nervous system
  • Myasthenia gravis and other myoneural disorders
  • Muscular dystrophy
  • Muscular myopathy
  • Cerebral palsy and other paralytic syndromes
  • Toxic encephalopathy
  • Hydrocephalus
  • Other, please state

H Disorders of the eye

  • Disorders of eyelid
  • Xanthelasma of eyelid
  • Disorders of lachrymal system
  • Disorders of orbit
  • Conjunctivitis
  • Disorders of sclera
  • Disorders of cornea
  • Iridocyclitis
  • Senile cataract
  • Other cataract
  • Other disorders of lens
  • Retinal disorders
  • Glaucoma
  • Other disorders of vitreous body and globe in diseases classified elsewhere
  • Disorders of optic nerve and visual pathways
  • Disorders of ocular muscles, binocular movement, accommodation and refraction
  • Visual disturbances and blindness
  • Other, please state

H Disorders of the ear

  • Diseases of middle ear and mastoid
  • Diseases of inner ear
  • Other, please state

I Heart disease

  • Rheumatic heart disease, unspecified
  • Hypertensive diseases
  • Angina pectoris
  • Acute myocardial infarction
  • Atrial septal defect
  • Chronic ischaemic heart disease
  • Pulmonary embolism
  • Other pulmonary heart diseases
  • Nonrheumatic mitral valve disorders
  • Pulmonary valve disorders
  • Endocarditis
  • Myocarditis
  • Cardiomyopathy
  • Atrioventricular arrhythmia
  • Heart failure
  • Other, please state

I Cerebrovascular diseases

  • Subarachnoid haemorrhage
  • Intracerebral haemorrhage
  • Cerebral infarction
  • Stroke, not specified as haemorrhage or infarction
  • Atherosclerosis
  • Aneurysm and dissection
  • Raynaud's syndrome
  • Thromboangiitis obliterans [Buerger]
  • Arterial embolism and thrombosis
  • Phlebitis and thrombophlebitis
  • Haemorrhoids
  • Oesophageal varices
  • Varicose veins of other sites
  • Lymphadenitis
  • Hypotension
  • Other, please state

J Respiratory disease

  • Acute upper respiratory infections of multiple and unspecified sites
  • Influenza
  • Viral pneumonia
  • Bacterial pneumonia
  • Pneumonia due to other infectious organisms, not elsewhere classified
  • Abscess of lung and mediastinum
  • Pyothorax
  • Acute bronchitis
  • Acute bronchiolitis
  • Vasomotor and allergic rhinitis
  • Chronic rhinitis, nasopharyngitis and pharyngitis
  • Chronic sinusitis
  • Nasal polyp
  • Chronic diseases of tonsils and adenoids
  • Diseases of vocal cords and larynx, not elsewhere classified
  • Chronic Bronchitis
  • Emphysema
  • Chronic obstructive pulmonary disease (COPD)
  • Asthma
  • Byssinosis
  • Bronchiectasis
  • Pneumoconiosis
  • Hypersensitivity pneumonitis due to organic dust
  • Other interstitial lung disease
  • Adult respiratory distress syndrome
  • Pulmonary edema
  • Pneumothorax
  • Respiratory failure, not elsewhere classified
  • Other, please state

K Diseases of oral cavity, salivary glands and jaws

  • Dental caries
  • Gingivitis and periodontal diseases
  • Dentofacial anomalies [including malocclusion]
  • Stomatitis and related lesions
  • Diseases of tongue
  • Other, please state

K Diseases of oesophagus, stomach, duodenum and appendix

  • Oesophagitis
  • Gastro-oesophageal reflux disease
  • Other diseases of oesophagus
  • Gastric ulcer
  • Duodenal ulcer
  • Peptic ulcer, site unspecified
  • Gastrojejunal ulcer
  • Gastritis and duodenitis
  • Dyspepsia
  • Other, please state

K Hernia, colon and intestine disease

  • Hernia
  • Crohn's disease
  • Ulcerative colitis
  • Other non-infective gastro-enteritis and colitis
  • Vascular disorders of intestine
  • Paralytic ileus and intestinal obstruction without hernia
  • Diverticular disease of intestine
  • Irritable bowel syndrome
  • Fissure and fistula of anal and rectal regions
  • Abscess of anal and rectal regions
  • Intestinal malabsorption
  • Other, please state

K Diseases of peritoneum, liver

  • Peritonitis
  • Alcoholic liver disease
  • Toxic liver disease
  • Chronic hepatitis
  • Fibrosis and cirrhosis of liver
  • Cholelithiasis/Cholecystitis
  • Acute pancreatitis
  • Other, please state

L Skin, nail and hair disorders

  • Infections of the skin and subcutaneous tissue
  • Bullous disorders
  • Atopic dermatitis
  • Allergic contact dermatitis
  • Irritant contact dermatitis
  • Dermatitis due to substances taken internally
  • Pruritus
  • Psoriasis/Parapsoriasis
  • Urticaria
  • Erythema nodosum
  • Sunburn
  • Nail disorders
  • Alopecia areata
  • Hypertrichosis
  • Acne
  • Vitiligo
  • Other, please state

M Arthritis, arthrosis, systemic connective disorders, spine disorders

  • Bacterial arthritis
  • Reactive arthritis
  • Rheumatoid arthritis
  • Juvenile arthritis
  • Gout
  • Other arthritis
  • Polyarthrosis
  • Coxarthrosis
  • Gonarthrosis [arthrosis of knee]
  • Arthrosis of first carpometacarpal joint
  • Other arthrosis
  • Deformities of fingers and toes
  • Deformities of limbs
  • Deformities of spine including scoliosis
  • Disorders of patella
  • Internal derangement of knee
  • Pathological dislocation and subluxation of joint
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Polymyalgia rheumatic
  • Other systemic involvement of connective tissue
  • Spine disk disorders
  • Lumbago with sciatica
  • Low back pain
  • Other, please state

M Disorders of muscles, bones, synovialis, bursa, cartilage

  • Myositis
  • Calcification and ossification of muscle
  • Contracture of muscle
  • Chronic crepitant synovitis of hand and wrist
  • Bursitis of hand
  • Olecranon bursitis
  • Prepatellar bursitis
  • Other bursitis
  • Rotator cuff syndrome
  • Bicipital tendinitis
  • Calcific tendinitis of shoulder
  • Impingement syndrome of shoulder
  • Medial epicondylitis
  • Lateral epicondylitis
  • Other Synovitis and tenosynovitis
  • Osteoporosis
  • Osteomalacia
  • Skeletal fluorosis
  • Osteomyelitis - Osteonecrosis
  • Chondropathies
  • Other, please state

N Kidney, renal pelvis disease

  • Glomerular diseases
  • Renal tubulo-interstitial diseases
  • Obstructive and reflux uropathy
  • Nephropathy
  • Renal failure
  • Urolithiasis
  • Cystitis
  • Urethral stricture
  • Other, please state

N Male and female related disorders

  • Hyperplasia of prostate
  • Other disorders of prostate
  • Torsion of testis
  • Orchitis and epididymitis
  • Male infertility
  • Disorders of penis
  • Other disorders of male genital organs
  • Benign mammary dysplasia
  • Salpingitis and oophoritis
  • Inflammatory disease of uterus
  • Inflammatory disease of cervix uteri
  • Female pelvic inflammatory disease, unspecified
  • Inflammation of vagina and vulva
  • Endometriosis
  • Other disorders of female genital and reproductive organs
  • Abnormal menstrual cycle
  • Female infertility
  • In vitro fertilisation
  • Spontaneous abortion
  • Molar pregnancy
  • Elective abortion
  • Other, please state

O+P Pregnancy and labour

  • Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
  • Eclampsia in pregnancy, labour or puerperium
  • Excessive vomiting in pregnancy
  • Venous complications in pregnancy
  • Infections of genito-urinary tract in pregnancy
  • Diabetes mellitus in pregnancy
  • Malnutrition in pregnancy
  • Other specified pregnancy-related conditions
  • Complications of labour and delivery
  • Preterm delivery
  • Extremely low birth weight
  • Other low birth weight
  • Exceptionally large baby
  • Birth trauma
  • Congenital viral diseases
  • Foetal death of unspecified cause
  • Other, please state

S Injuries

  • Injuries to the head
  • Injuries to the thorax
  • Injuries to the abdomen, lower back, lumbar spine and pelvis
  • Injuries to the shoulder, arm and fingers
  • Injuries to the hip and thigh
  • Injuries to the knee and lower leg, ankle and foot
  • Other, please state

Other health related outcomes

  • Biomarkers
  • Lifestyle change
  • Sickness absence
  • Sleep
  • Work participation

Biological samples collected

  • Blood
  • Urine

6. Other Information

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking

Specify: Environmental other
  Area deprivation index
Possibility for linkage to data registries/data enrichment via data linkage

  • Employment status
  • Hospital discharge
  • Medication usage
  • Mortality register

Please describe plans that are funded or most likely to be funded
  Pesticides, light, noise, water