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Date of filling in this questionnaire or last update: 24/01/2021
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  PIAMA
Country
 

  • Netherlands
Name
  Ulrike Gehring
Institution
  Utrecht University
Email
  u.gehring@uu.nl
Personal website
  https://www.uu.nl/staff/UGehring
Name
  Roel Vermeulen
Institution
  Utrecht University
Email
  r.c.h.vermeulen@uu.nl
Personal website
  https://www.uu.nl/staff/RCHVermeulen
Name of committee
  Start project - Rotterdam, MEC (Medisch Ethische Commisie Erasmus Universiteit Rotterdam/Academische Ziekenhuizen Rotterdam) - Groningen, MEC (Medisch Ethische Commisie Academisch ziekenhuis Groningen) - Utrecht/Bilthoven, MEC-TNO (Medisch Ethische Commisie -Toegepast Natuurwetenschappelijk Onderzoek) Age 4 years Utrecht, CCMO (Centrale Commissie Mensgebonden Onderzoek) Age 8 years - Utrecht, CCMO (Centrale Commissie Mensgebonden Onderzoek), - Rotterdam, MEC (Medisch Ethische Commisie Erasmus Universiteit Rotterdam/Academische Ziekenhuizen Rotterdam) - Groningen, MEC (Medisch Ethische Commisie Academisch ziekenhuis Groningen) Age 12 years Utrecht, METC (Medisch Ethische ToetsingsCommissie) Age 16 years - Utrecht, METC (Medisch Ethische ToetsingsCommissie) - Groningen, METC (Medisch Ethische Toetsings Commissie) Ages 18, 20 & 23 years Utrecht, METC (Medisch Ethische Toetsingscommissie)
Upload files
 

Or provide website
 

  • https://piama.iras.uu.nl/english/
Contact Principal Investigator (name)
  Ulrike Gehring
Data access policy (briefly describe)
  https://piama.iras.uu.nl/english/
Is this cohort part of a consortium? (name consortium)
  No
Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
  The PIAMA study was set up (1) To investigate the effect of mite-allergen avoidance on the incidence of asthma in childhood (Intervention Study); and (2) To investigate the incidence of asthma in children from 0 to 8 years of age (Natural History Study). Main outcomes: IgE, BHR, eNO, SPT, asthma & allergy symptoms & diagnosis Main exposures: allergens, endotoxin, mould components, indoor air pollution (ETS & NO2), outdoor air pollution (from traffic), nutrition (allergens, antioxidants, fatty acids, breast feeding etc). In addition, anthropometric data have been collected since birth. In the course of the study genetic and genomic studies were incorporated also. When the study was extended beyond the originally planned 8 years, into adolescence, early markers of cardiometabolic risk were included in the study as additional health outcomes.
Study design (please select as many as appropriate)
 

  • Prospective cohort
Source population (please select as many as appropriate)
 

  • General population: National
Inclusion criteria
  PIAMA is a population-based birth cohort. Pregnant women were recruited during their second trimester from the general population through 52 antenatal clinics located in the North, West and Center of the Netherlands, resulting in a baseline study population of 3963 children born in 1996 and 1997.
Exclusion criteria
  Not being able to compelte questionnaires in Dutch.
Enrollment
  Completed
Age range at entry (main cohort)
 

Minimum Maximum Mean
0 0 0

Men at enrollment
  2057
Women at enrollment
  1906
Children (<18 years) at enrollment
  3963
Men at last follow-up
  1100
Women at last follow-up
  1106
Children (<18 years) at last follow-up
  0
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Active (contact with participants)
Active (contact with participants) (specify)
 

  • questionnaire and medical examinations
First follow-up period (provide year)
  3 months (1996-1997)
Last follow-up period (provide year)
  23-24 years (2020-21)
Number of follow-ups after baseline (provide number)
  13
Comments
  last follow-up is still ongoing
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
Occupational history/time frame
  Other (specify)
Specify: Other
  current at age 23-24 yrs
Occupational coding performed
  No
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Questionnaire, individual (self-recording or interview)
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Questionnaire, individual (self-recording or interview)
Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  spirometry, blood pressure, BMI
Specify: Biomarker
  total and specific IgE, cholesterol, HbA1c
Outcome type (please select as many as appropriate)
 

  • Morbidity
Diagnostic groups based on ICD10
 

  • E Malnutrition and obesity
  • J Respiratory disease
  • L Skin, nail and hair disorders
E Malnutrition and obesity
 

  • Obesity
J Respiratory disease
 

  • Acute upper respiratory infections of multiple and unspecified sites
  • Influenza
  • Acute bronchitis
  • Vasomotor and allergic rhinitis
  • Asthma
L Skin, nail and hair disorders
 

  • Atopic dermatitis
  • Dermatitis due to substances taken internally
Other health related outcomes
 

  • Sleep
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
Biological processing
 

  • DNA
Genetic and other lab analyses
 

  • Epigenomics
  • Genomics / GWAS
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking
Specify: Environmental other
  noise, green space