Date of filling in this questionnaire or last update: 03/11/2020
Cohort name
  HSE Styrene Cohort

  • United Kingdom

  Damien McElvenny
  Institute of Occupational Medicine
Personal website
Name of committee
  A new ethics application is required for any additional analyses
Or provide website

  • This cohort was part of the IARC styrene study (Kogevinas PI), but has an analysis of this cohort has not separately been published.

Contact Principal Investigator (name)
  Damien McElvenny
Data access policy (briefly describe)
  As well as ethics clearance, clearance will also be required from the Health Research Authority's Confidentiality Advisory Group (HRA CAG) and NHS DIgital's Information Group Advising on the Release of Data (IGARD). Please contact the PI to discuss.
Is this cohort part of a consortium? (name consortium)
  Yes, part of an update to the IARC styrene study that is being coordinated by Prof. Henrik Kolstad at Aarhus Universityi
Participation in pooled analyses

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).

Main aim of cohort, please briefly describe the main objectives of the cohort
  Assess exposure response associations for styrene and malignant and non-malignant health outcomes
Study design (please select as many as appropriate)

  • Retrospective cohort

Source population (please select as many as appropriate)

  • Industry / occupation-based

Comparators (please select as many as appropriate)

  • Internal study population
  • External study population (includes SMR/SIR studies)

Inclusion criteria
  Ever employed in glass reinforced plastics industry from 1961 to 1988
Exclusion criteria
Age range at entry (main cohort)

Minimum Maximum Mean
18 70

Men at enrollment
Women at enrollment
Children (<18 years) at enrollment
Men at last follow-up
Women at last follow-up
Children (<18 years) at last follow-up
Type of data for outcome follow-up (please select as many as appropriate)

  • Death certificate
  • Use of registers (specify)

Death certificate (specify)

  • National Mortality Register for England and Wales

Specify: Use of registers

  • National Cancer Registration Registers for England and Wales

First follow-up period (provide year)
Last follow-up period (provide year)
Number of follow-ups after baseline (provide number)
Participation at last follow-up (if known)
Source of exposure data collected (please select as many as appropriate)

  • Job-employment records

Occupational history/time frame
  Current, at enrollment
Occupational coding performed
Industry (specify coding system used)

  • Glass-reinforced plastics manufacturing

Types of exposure measurements

  • Other (specify)

Specify: Other
  Exposures applied previously from exposure assessment as part of the IARC study
Methods for exposure assessment (please select as many as appropriate)

  • Data modelling

Main categories

  • Solvents

Solvents | Aliphatic and alicyclic hydrocarbon solvents

  • Other (specify)

Solvents | Aliphatic and alicyclic hydrocarbon solvents | Specify: Other
  Styrene and styrene oxide
Baseline - type of outcome data collected (select more than one if applicable)

  • Death certificates

Follow-up - type of outcome data collected (select more than one if applicable)

  • Death certificates
  • Registry-based


  • Cancer incidence

Outcome type (please select as many as appropriate)

  • Mortality
  • Morbidity

Diagnostic groups based on ICD10

  • A Bacterial infectious disease, type of microorganisms*
  • B Viral infections, type of microorganisms*
  • B99 Other and unspecified infectious diseases, type of microorganisms*
  • C + D Neoplasms
  • D Diseases of blood and blood-forming organs excl. leukemia
  • E Endocrinological disease
  • E Malnutrition and obesity
  • E Metabolism disease
  • F Mental disorders
  • G Disease in the nervous system
  • H Disorders of the eye
  • H Disorders of the ear
  • I Heart disease
  • I Cerebrovascular diseases
  • J Respiratory disease
  • K Diseases of oral cavity, salivary glands and jaws
  • K Diseases of oesophagus, stomach, duodenum and appendix
  • K Hernia, colon and intestine disease
  • K Diseases of peritoneum, liver
  • L Skin, nail and hair disorders
  • M Arthritis, arthrosis, systemic connective disorders, spine disorders
  • M Disorders of muscles, bones, synovialis, bursa, cartilage
  • N Kidney, renal pelvis disease
  • N Male and female related disorders
  • S Injuries

A Bacterial infectious disease, type of microorganisms*

  • Anasakis
  • Bartonella
  • Bordetella pertussis
  • Borrelia
  • Brucella
  • Campylobacter
  • Coxiella
  • Clostridium tetani
  • Clostridium difficile
  • Francisella tularensis
  • Helicobacter pylori
  • Legionella
  • Leishmania
  • Leptospira
  • Mycobacterium bovis
  • Mycobacterium tuberculosis
  • Neisseria gonorrhoeae
  • Neisseria meningitides
  • Pseudomonas aeruginosa
  • Rickettsia
  • Salmonella
  • Shigella
  • Staphylococcus
  • Streptococcus
  • Toxocara
  • Toxoplasma gondii
  • Trachomatis
  • Treponema pallidum
  • Trichomonas vaginalis
  • Other bacterial infections, please state

B Viral infections, type of microorganisms

  • Cytomegalovirus
  • Hantavirus
  • Hepatitis (A,B,C,E)
  • HIV virus
  • Human herpes virus
  • Human papilloma virus
  • Human T-lymphotrophic virus
  • Influenza virus
  • Measles virus
  • Monkey pox virus
  • Mumps virus
  • Parvovirus
  • Rhinovirus
  • Rubella virus
  • Tick-borne encephalitis virus
  • Varicella zoster virus
  • West Nile virus
  • SARS coronavirus
  • Other viral infections, please state

B99 Other and unspecified infectious diseases, type of microorganisms

  • Giardia lamblia
  • Chlamydia
  • Other infections, please state

C + D Neoplasms

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
  • Other, please state

D Diseases of blood and blood-forming organs excl. leukemia

  • Diseases of spleen
  • Polycythaemia vera
  • Myelodysplastic syndromes
  • Essential (haemorrhagic) thrombocythaemia
  • Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
  • Iron deficiency
  • Vitamin deficiency
  • Aplastic and other anemias
  • Acquired haemolytic anaemia
  • Enzyme disorders including Thalassaemia and Sickle-cell disorders
  • Other anaemias
  • Anaemia, unspecified
  • Coagulation defects
  • Purpura and other haemorrhagic conditions
  • Other diseases of blood and blood-forming organs
  • Immunodeficiency
  • Sarcoidosis
  • Other, please state

E Endocrinological disease

  • Thyroidea
  • Parathyroidea
  • Diabetes mellitus
  • Pituitary
  • Other endocrinological disease
  • Adrenogenital disorders
  • Testicular dysfunction
  • Other, please state

E Malnutrition and obesity

  • Vitamin A deficiency
  • Thiamine deficiency
  • Deficiency of other B group vitamins
  • Vitamin D deficiency
  • Deficiency of vitamin E
  • Deficiency of vitamin K
  • Vitamin deficiency, unspecified
  • Calcium deficiency
  • Deficiency of other nutrient elements
  • Other, please state

E Metabolism disease

  • Disorder of amino-acid metabolism, unspecified
  • Lactose intolerance
  • Disorders of sphingolipid metabolism and other lipid storage disorders
  • Disorders of glycosaminoglycan and glucoprotein metabolism metabolism
  • Disorders of lipoprotein metabolism and other lipidaemias
  • Hypercholesterolemia
  • Disorders of purine and pyrimidine metabolism
  • Disorders of porphyrin and bilirubin metabolism
  • Disorders of mineral metabolism
  • Cystic fibrosis
  • Other, please state

F Mental disorders

  • Dementia
  • Personality and behavioural disorders
  • Schizophrenia
  • Mood [affective] disorders
  • Depression
  • Eating disorders
  • Mental retardation
  • Disorders of psychological development including autism and Aspergers syndrome
  • Other mental disorder, not otherwise specified
  • Other, please state

G Disease in the nervous system

  • Infectious diseases of the central nervous system
  • Non-infectious encephalitis, myelitis and encephalomyelitis
  • Intracranial and intraspinal abscess and granuloma
  • Systemic atrophies primarily affecting the central nervous system including
  • Huntington's disease and Hereditary ataxia
  • Spinal muscular atrophy and related syndromes
  • Parkinson's disease
  • Dystonia
  • Alzheimer's disease
  • Other degenerative disorders of nervous system in diseases classified elsewhere
  • Multiple sclerosis
  • Epilepsy
  • Migraine
  • Sleep disorders
  • Facial nerve disorders
  • Disorders of other cranial nerves
  • Nerve root and plexus disorders
  • Carpal tunnel syndrome
  • Lesion of ulnar nerve
  • Lesion of radial nerve
  • Other mononeuropathies
  • Polyneuropathies and other disorders of the peripheral nervous system
  • Myasthenia gravis and other myoneural disorders
  • Muscular dystrophy
  • Muscular myopathy
  • Cerebral palsy and other paralytic syndromes
  • Toxic encephalopathy
  • Hydrocephalus
  • Other, please state

H Disorders of the eye

  • Disorders of eyelid
  • Xanthelasma of eyelid
  • Disorders of lachrymal system
  • Disorders of orbit
  • Conjunctivitis
  • Disorders of sclera
  • Disorders of cornea
  • Iridocyclitis
  • Senile cataract
  • Other cataract
  • Other disorders of lens
  • Retinal disorders
  • Glaucoma
  • Other disorders of vitreous body and globe in diseases classified elsewhere
  • Disorders of optic nerve and visual pathways
  • Disorders of ocular muscles, binocular movement, accommodation and refraction
  • Visual disturbances and blindness
  • Other, please state

H Disorders of the ear

  • Diseases of middle ear and mastoid
  • Diseases of inner ear
  • Other, please state

I Heart disease

  • Rheumatic heart disease, unspecified
  • Hypertensive diseases
  • Angina pectoris
  • Acute myocardial infarction
  • Atrial septal defect
  • Chronic ischaemic heart disease
  • Pulmonary embolism
  • Other pulmonary heart diseases
  • Nonrheumatic mitral valve disorders
  • Pulmonary valve disorders
  • Endocarditis
  • Myocarditis
  • Cardiomyopathy
  • Atrioventricular arrhythmia
  • Heart failure
  • Other, please state

I Cerebrovascular diseases

  • Subarachnoid haemorrhage
  • Intracerebral haemorrhage
  • Cerebral infarction
  • Stroke, not specified as haemorrhage or infarction
  • Atherosclerosis
  • Aneurysm and dissection
  • Raynaud's syndrome
  • Thromboangiitis obliterans [Buerger]
  • Arterial embolism and thrombosis
  • Phlebitis and thrombophlebitis
  • Haemorrhoids
  • Oesophageal varices
  • Varicose veins of other sites
  • Lymphadenitis
  • Hypotension
  • Other, please state

J Respiratory disease

  • Acute upper respiratory infections of multiple and unspecified sites
  • Influenza
  • Viral pneumonia
  • Bacterial pneumonia
  • Pneumonia due to other infectious organisms, not elsewhere classified
  • Abscess of lung and mediastinum
  • Pyothorax
  • Acute bronchitis
  • Acute bronchiolitis
  • Vasomotor and allergic rhinitis
  • Chronic rhinitis, nasopharyngitis and pharyngitis
  • Chronic sinusitis
  • Nasal polyp
  • Chronic diseases of tonsils and adenoids
  • Diseases of vocal cords and larynx, not elsewhere classified
  • Chronic Bronchitis
  • Emphysema
  • Chronic obstructive pulmonary disease (COPD)
  • Asthma
  • Byssinosis
  • Bronchiectasis
  • Pneumoconiosis
  • Hypersensitivity pneumonitis due to organic dust
  • Other interstitial lung disease
  • Adult respiratory distress syndrome
  • Pulmonary edema
  • Pneumothorax
  • Respiratory failure, not elsewhere classified
  • Other, please state

K Diseases of oral cavity, salivary glands and jaws

  • Dental caries
  • Gingivitis and periodontal diseases
  • Dentofacial anomalies [including malocclusion]
  • Stomatitis and related lesions
  • Diseases of tongue
  • Other, please state

K Diseases of oesophagus, stomach, duodenum and appendix

  • Oesophagitis
  • Gastro-oesophageal reflux disease
  • Other diseases of oesophagus
  • Gastric ulcer
  • Duodenal ulcer
  • Peptic ulcer, site unspecified
  • Gastrojejunal ulcer
  • Gastritis and duodenitis
  • Dyspepsia
  • Other, please state

K Hernia, colon and intestine disease

  • Hernia
  • Crohn's disease
  • Ulcerative colitis
  • Other non-infective gastro-enteritis and colitis
  • Vascular disorders of intestine
  • Paralytic ileus and intestinal obstruction without hernia
  • Diverticular disease of intestine
  • Irritable bowel syndrome
  • Fissure and fistula of anal and rectal regions
  • Abscess of anal and rectal regions
  • Intestinal malabsorption
  • Other, please state

K Diseases of peritoneum, liver

  • Peritonitis
  • Alcoholic liver disease
  • Toxic liver disease
  • Chronic hepatitis
  • Fibrosis and cirrhosis of liver
  • Cholelithiasis/Cholecystitis
  • Acute pancreatitis
  • Other, please state

L Skin, nail and hair disorders

  • Infections of the skin and subcutaneous tissue
  • Bullous disorders
  • Atopic dermatitis
  • Allergic contact dermatitis
  • Irritant contact dermatitis
  • Dermatitis due to substances taken internally
  • Pruritus
  • Psoriasis/Parapsoriasis
  • Urticaria
  • Erythema nodosum
  • Sunburn
  • Nail disorders
  • Alopecia areata
  • Hypertrichosis
  • Acne
  • Vitiligo
  • Other, please state

M Arthritis, arthrosis, systemic connective disorders, spine disorders

  • Bacterial arthritis
  • Reactive arthritis
  • Rheumatoid arthritis
  • Juvenile arthritis
  • Gout
  • Other arthritis
  • Polyarthrosis
  • Coxarthrosis
  • Gonarthrosis [arthrosis of knee]
  • Arthrosis of first carpometacarpal joint
  • Other arthrosis
  • Deformities of fingers and toes
  • Deformities of limbs
  • Deformities of spine including scoliosis
  • Disorders of patella
  • Internal derangement of knee
  • Pathological dislocation and subluxation of joint
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Polymyalgia rheumatic
  • Other systemic involvement of connective tissue
  • Spine disk disorders
  • Lumbago with sciatica
  • Low back pain
  • Other, please state

M Disorders of muscles, bones, synovialis, bursa, cartilage

  • Myositis
  • Calcification and ossification of muscle
  • Contracture of muscle
  • Chronic crepitant synovitis of hand and wrist
  • Bursitis of hand
  • Olecranon bursitis
  • Prepatellar bursitis
  • Other bursitis
  • Rotator cuff syndrome
  • Bicipital tendinitis
  • Calcific tendinitis of shoulder
  • Impingement syndrome of shoulder
  • Medial epicondylitis
  • Lateral epicondylitis
  • Other Synovitis and tenosynovitis
  • Osteoporosis
  • Osteomalacia
  • Skeletal fluorosis
  • Osteomyelitis - Osteonecrosis
  • Chondropathies
  • Other, please state

N Kidney, renal pelvis disease

  • Glomerular diseases
  • Renal tubulo-interstitial diseases
  • Obstructive and reflux uropathy
  • Nephropathy
  • Renal failure
  • Urolithiasis
  • Cystitis
  • Urethral stricture
  • Other, please state

N Male and female related disorders

  • Hyperplasia of prostate
  • Other disorders of prostate
  • Torsion of testis
  • Orchitis and epididymitis
  • Male infertility
  • Disorders of penis
  • Other disorders of male genital organs
  • Benign mammary dysplasia
  • Salpingitis and oophoritis
  • Inflammatory disease of uterus
  • Inflammatory disease of cervix uteri
  • Female pelvic inflammatory disease, unspecified
  • Inflammation of vagina and vulva
  • Endometriosis
  • Other disorders of female genital and reproductive organs
  • Abnormal menstrual cycle
  • Female infertility
  • In vitro fertilisation
  • Spontaneous abortion
  • Molar pregnancy
  • Elective abortion
  • Other, please state

S Injuries

  • Injuries to the head
  • Injuries to the thorax
  • Injuries to the abdomen, lower back, lumbar spine and pelvis
  • Injuries to the shoulder, arm and fingers
  • Injuries to the hip and thigh
  • Injuries to the knee and lower leg, ankle and foot
  • Other, please state

6. Other Information
Possibility for linkage to data registries/data enrichment via data linkage

  • Cancer incidence
  • Hospital discharge
  • Mortality register

Please describe plans that are funded or most likely to be funded
  Update to HSE study has been funded by the Health and Safety Executive
Update to the IARC International Study has been funded by Aarhus University