Date of filling in this questionnaire or last update: 22/10/2020
Cohort name
  Cohort with blood lead measurements

  • United Kingdom

  Damien McElvenny
  Institute of Occupational Medicine
Personal website
Name of committee
  NHS South Manchester
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Contact Principal Investigator (name)
  Damien McElvenny
Data access policy (briefly describe)
  Will need NHS ethics, HRA CAG and NHS Digital IGARD clearances
Is this cohort part of a consortium? (name consortium)
  Yes, IARC coordinated international study of workers with blood lead measurements
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Participation in pooled analyses

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).

Main aim of cohort, please briefly describe the main objectives of the cohort
  To determine if lead is a carcinogen
Study design (please select as many as appropriate)

  • Prospective cohort

Source population (please select as many as appropriate)

  • Industry / occupation-based

Comparators (please select as many as appropriate)

  • External study population (includes SMR/SIR studies)

Inclusion criteria
  Workers with blood lead measurements
Age range at entry (main cohort)

Minimum Maximum Mean
18 Not specified 35

Men at enrollment
Women at enrollment
Men at last follow-up
Women at last follow-up
Children (<18 years) at last follow-up
Type of data for outcome follow-up (please select as many as appropriate)

  • Death certificate

First follow-up period (provide year)
Last follow-up period (provide year)
Number of follow-ups after baseline (provide number)
Source of exposure data collected (please select as many as appropriate)

  • Other (specify)

Specify: Other
  Blood lead measurements
Occupational history/time frame
  Other (specify)
Specify: Other
  Lifetime at enrolment
Occupational coding performed
Types of exposure measurements

  • Biomarkers (see also section 5)

Methods for exposure assessment (please select as many as appropriate)

  • Measurements (external sampling, biomarkers)

Main categories

  • Metals and metal oxides

Metals and metal oxides

  • Lead and all compounds

Baseline - type of outcome data collected (select more than one if applicable)

  • Death certificates
  • Registry-based


  • Cancer incidence
  • Mortality register

Outcome type (please select as many as appropriate)

  • Mortality
  • Morbidity

Diagnostic groups based on ICD10

  • C + D Neoplasms
  • I Heart disease
  • I Cerebrovascular diseases
  • J Respiratory disease
  • N Kidney, renal pelvis disease

C + D Neoplasms

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
  • Other, please state

I Heart disease

  • Rheumatic heart disease, unspecified
  • Hypertensive diseases
  • Angina pectoris
  • Acute myocardial infarction
  • Atrial septal defect
  • Chronic ischaemic heart disease
  • Pulmonary embolism
  • Other pulmonary heart diseases
  • Nonrheumatic mitral valve disorders
  • Pulmonary valve disorders
  • Endocarditis
  • Myocarditis
  • Cardiomyopathy
  • Atrioventricular arrhythmia
  • Heart failure
  • Other, please state

I Cerebrovascular diseases

  • Subarachnoid haemorrhage
  • Intracerebral haemorrhage
  • Cerebral infarction
  • Stroke, not specified as haemorrhage or infarction
  • Atherosclerosis
  • Aneurysm and dissection
  • Raynaud's syndrome
  • Thromboangiitis obliterans [Buerger]
  • Arterial embolism and thrombosis
  • Phlebitis and thrombophlebitis
  • Haemorrhoids
  • Oesophageal varices
  • Varicose veins of other sites
  • Lymphadenitis
  • Hypotension
  • Other, please state

J Respiratory disease

  • Acute upper respiratory infections of multiple and unspecified sites
  • Influenza
  • Viral pneumonia
  • Bacterial pneumonia
  • Pneumonia due to other infectious organisms, not elsewhere classified
  • Abscess of lung and mediastinum
  • Pyothorax
  • Acute bronchitis
  • Acute bronchiolitis
  • Vasomotor and allergic rhinitis
  • Chronic rhinitis, nasopharyngitis and pharyngitis
  • Chronic sinusitis
  • Nasal polyp
  • Chronic diseases of tonsils and adenoids
  • Diseases of vocal cords and larynx, not elsewhere classified
  • Chronic Bronchitis
  • Emphysema
  • Chronic obstructive pulmonary disease (COPD)
  • Asthma
  • Byssinosis
  • Bronchiectasis
  • Pneumoconiosis
  • Hypersensitivity pneumonitis due to organic dust
  • Other interstitial lung disease
  • Adult respiratory distress syndrome
  • Pulmonary edema
  • Pneumothorax
  • Respiratory failure, not elsewhere classified
  • Other, please state

N Kidney, renal pelvis disease

  • Glomerular diseases
  • Renal tubulo-interstitial diseases
  • Obstructive and reflux uropathy
  • Nephropathy
  • Renal failure
  • Urolithiasis
  • Cystitis
  • Urethral stricture
  • Other, please state

Biological samples collected

  • Blood

  Blood lead measurements
6. Other Information
Possibility for linkage to data registries/data enrichment via data linkage

  • Cancer incidence
  • Mortality register