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Date of filling in this questionnaire or last update: 22/10/2020
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Cohort with blood lead measurements
Country
 

  • United Kingdom
Name
  Damien McElvenny
Institution
  Institute of Occupational Medicine
Email
  damien.mcelvenny@iom-world.org
Phone
  +441314498085
Personal website
  https://www.iom-world.org/research/our-scientists/prof-damien-mcelvenny/
Name of committee
  NHS South Manchester
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Contact Principal Investigator (name)
  Damien McElvenny
Data access policy (briefly describe)
  Will need NHS ethics, HRA CAG and NHS Digital IGARD clearances
Is this cohort part of a consortium? (name consortium)
  Yes, IARC coordinated international study of workers with blood lead measurements
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Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
  To determine if lead is a carcinogen
Study design (please select as many as appropriate)
 

  • Prospective cohort
Source population (please select as many as appropriate)
 

  • Industry / occupation-based
Comparators (please select as many as appropriate)
 

  • External study population (includes SMR/SIR studies)
Inclusion criteria
  Workers with blood lead measurements
Enrollment
  Completed
Age range at entry (main cohort)
 

Minimum Maximum Mean
18 Not specified 35

Men at enrollment
  9122
Women at enrollment
  1352
Men at last follow-up
  9122
Women at last follow-up
  1352
Children (<18 years) at last follow-up
  0
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Death certificate
First follow-up period (provide year)
  1975
Last follow-up period (provide year)
  2011
Number of follow-ups after baseline (provide number)
  1
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Other (specify)
Specify: Other
  Blood lead measurements
Occupational history/time frame
  Other (specify)
Specify: Other
  Lifetime at enrolment
Occupational coding performed
  No
Types of exposure measurements
 

  • Biomarkers (see also section 5)
Methods for exposure assessment (please select as many as appropriate)
 

  • Measurements (external sampling, biomarkers)
Main categories
 

  • Metals and metal oxides
Metals and metal oxides
 

  • Lead and all compounds
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Death certificates
  • Registry-based
Registry-based
 

  • Cancer incidence
  • Mortality register
Outcome type (please select as many as appropriate)
 

  • Mortality
  • Morbidity
Diagnostic groups based on ICD10
 

  • C + D Neoplasms
  • I Heart disease
  • I Cerebrovascular diseases
  • J Respiratory disease
  • N Kidney, renal pelvis disease
C + D Neoplasms
 

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
  • Other, please state
I Heart disease
 

  • Rheumatic heart disease, unspecified
  • Hypertensive diseases
  • Angina pectoris
  • Acute myocardial infarction
  • Atrial septal defect
  • Chronic ischaemic heart disease
  • Pulmonary embolism
  • Other pulmonary heart diseases
  • Nonrheumatic mitral valve disorders
  • Pulmonary valve disorders
  • Endocarditis
  • Myocarditis
  • Cardiomyopathy
  • Atrioventricular arrhythmia
  • Heart failure
  • Other, please state
I Cerebrovascular diseases
 

  • Subarachnoid haemorrhage
  • Intracerebral haemorrhage
  • Cerebral infarction
  • Stroke, not specified as haemorrhage or infarction
  • Atherosclerosis
  • Aneurysm and dissection
  • Raynaud's syndrome
  • Thromboangiitis obliterans [Buerger]
  • Arterial embolism and thrombosis
  • Phlebitis and thrombophlebitis
  • Haemorrhoids
  • Oesophageal varices
  • Varicose veins of other sites
  • Lymphadenitis
  • Hypotension
  • Other, please state
J Respiratory disease
 

  • Acute upper respiratory infections of multiple and unspecified sites
  • Influenza
  • Viral pneumonia
  • Bacterial pneumonia
  • Pneumonia due to other infectious organisms, not elsewhere classified
  • Abscess of lung and mediastinum
  • Pyothorax
  • Acute bronchitis
  • Acute bronchiolitis
  • Vasomotor and allergic rhinitis
  • Chronic rhinitis, nasopharyngitis and pharyngitis
  • Chronic sinusitis
  • Nasal polyp
  • Chronic diseases of tonsils and adenoids
  • Diseases of vocal cords and larynx, not elsewhere classified
  • Chronic Bronchitis
  • Emphysema
  • Chronic obstructive pulmonary disease (COPD)
  • Asthma
  • Byssinosis
  • Bronchiectasis
  • Pneumoconiosis
  • Hypersensitivity pneumonitis due to organic dust
  • Other interstitial lung disease
  • Adult respiratory distress syndrome
  • Pulmonary edema
  • Pneumothorax
  • Respiratory failure, not elsewhere classified
  • Other, please state
N Kidney, renal pelvis disease
 

  • Glomerular diseases
  • Renal tubulo-interstitial diseases
  • Obstructive and reflux uropathy
  • Nephropathy
  • Renal failure
  • Urolithiasis
  • Cystitis
  • Urethral stricture
  • Other, please state
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
Comments
  Blood lead measurements
6. Other Information
Possibility for linkage to data registries/data enrichment via data linkage
 

  • Cancer incidence
  • Mortality register