| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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PELAGIE
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Country
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Name
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Cécile Chevrier
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Institution
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Inserm U1085 IRSET
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Email
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cecile.chevrier@inserm.fr
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Name
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Ronan Garlantézec
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Institution
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Inserm U1085 IRSET
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Email
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ronan.garlantezec@chu-rennes.fr
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Website
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- http://www.pelagie-inserm.fr/
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Is this cohort part of a consortium? (name consortium)
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ATHLETES
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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To study the relationship between exposures to chemicals (domestic and occupational), reproduction and development
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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Comparators (please select as many as appropriate)
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- Internal study population
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 16 |
44 |
30 |
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Men at enrollment
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3421
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Women at enrollment
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3421
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Participation rate at enrollment (if known)
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80
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Hospital / physician diagnoses
- Other (specify)
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Active (contact with participants) (specify)
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- Birth outcomes, measurment of steroids hormones, neurodevelopment, post natal growth, puberty status...
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Hospital / Physician diagnoses (specify)
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Specify: Other
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- occupational exposures assessed : exposures to solvents, exposure to cosmtecis, healthcare workers exposures, shift work and worload
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Last follow-up period (provide year)
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2021
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Number of follow-ups after baseline (provide number)
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4
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Questionnaire, Personal (Occupational/industry modules)
- Job calendar
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Occupational history/time frame
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Current, at enrollment
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Occupational coding performed
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Yes
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Occupation (specify coding system used)
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Industry (specify coding system used)
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- CITI 1975, NACE , NAF 2003
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Types of exposure measurements
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- Biomarkers (see also section 5)
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Methods for exposure assessment (please select as many as appropriate)
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- Job Exposure Matrix
- Measurements (external sampling, biomarkers)
- Self-report
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Main categories
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Solvents | Aliphatic and alicyclic hydrocarbon solvents
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- Gasoline
- Solvent naphtha
- White spirit
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Solvents | Aromatic hydrocarbon solvents
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Solvents | Chlorinated hydrocarbon solvents
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- Chloroform
- Methylene chloride
- Perchloroethylene
- Trichloroethanes
- Trichloroethylene
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Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated
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- Alcohols
- Esters
- Glycol ethers
- Ketones
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Main categories | Other | Specify: Other
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JEM constructed on healthcare exposures and cosmetics
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Comments
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Glycol ethers metabolites and metabolites of chlorinated solvents measured in urinary samples collected at inclusion.
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Biomarker
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Glycol ethers, trichloroethanol, trichloacetic acid
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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neurodevlelopment, growh, puberty status
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Other health related outcomes
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Genetic and other lab analyses
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- Biomarkers (specify)
- Metabolomics
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| 6. Other Information |
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- Alcohol
- Anthropometry
- Demographics
- Diet
- Education
- Environmental, air pollution
- Environmental other (specify)
- Medical history
- Physical exercise
- Residential history
- Socioeconomic status
- Smoking
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