Date of filling in this questionnaire or last update: 12/01/2022
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  PELAGIE
Country
 

  • France

Name
  Cécile Chevrier
Institution
  Inserm U1085 IRSET
Email
  cecile.chevrier@inserm.fr
Name
  Ronan Garlantézec
Institution
  Inserm U1085 IRSET
Email
  ronan.garlantezec@chu-rennes.fr
Website
 

  • http://www.pelagie-inserm.fr/

Is this cohort part of a consortium? (name consortium)
  ATHLETES
Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).

Main aim of cohort, please briefly describe the main objectives of the cohort
  To study the relationship between exposures to chemicals (domestic and occupational), reproduction and development
Study design (please select as many as appropriate)
 

  • Prospective cohort

Source population (please select as many as appropriate)
 

  • Mother-child cohort

Comparators (please select as many as appropriate)
 

  • Internal study population

Enrollment
  Completed
Age range at entry (main cohort)
 

Minimum Maximum Mean
16 44 30

Men at enrollment
  3421
Women at enrollment
  3421
Participation rate at enrollment (if known)
  80
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Active (contact with participants)
  • Hospital / physician diagnoses
  • Other (specify)

Active (contact with participants) (specify)
 

  • Birth outcomes, measurment of steroids hormones, neurodevelopment, post natal growth, puberty status...

Hospital / Physician diagnoses (specify)
 

  • Birth defects

Specify: Other
 

  • occupational exposures assessed : exposures to solvents, exposure to cosmtecis, healthcare workers exposures, shift work and worload

Last follow-up period (provide year)
  2021
Number of follow-ups after baseline (provide number)
  4
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
  • Questionnaire, Personal (Occupational/industry modules)
  • Job calendar

Occupational history/time frame
  Current, at enrollment
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • CITP 1968, PCS 1994

Industry (specify coding system used)
 

  • CITI 1975, NACE , NAF 2003

Types of exposure measurements
 

  • Biomarkers (see also section 5)

Methods for exposure assessment (please select as many as appropriate)
 

  • Job Exposure Matrix
  • Measurements (external sampling, biomarkers)
  • Self-report

 

  • Matgene

Main categories
 

  • Solvents
  • Other (specify)

Solvents | Aliphatic and alicyclic hydrocarbon solvents
 

  • Gasoline
  • Solvent naphtha
  • White spirit

Solvents | Aromatic hydrocarbon solvents
 

  • Benzene

Solvents | Chlorinated hydrocarbon solvents
 

  • Chloroform
  • Methylene chloride
  • Perchloroethylene
  • Trichloroethanes
  • Trichloroethylene

Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated
 

  • Alcohols
  • Esters
  • Glycol ethers
  • Ketones

Main categories | Other | Specify: Other
  JEM constructed on healthcare exposures and cosmetics
Comments
  Glycol ethers metabolites and metabolites of chlorinated solvents measured in urinary samples collected at inclusion.
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Questionnaire, individual (self-recording or interview)

Specify: Biomarker
  Glycol ethers, trichloroethanol, trichloacetic acid
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)

Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  neurodevlelopment, growh, puberty status
Other health related outcomes
 

  • Biomarkers

5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Hair
  • Urine

Genetic and other lab analyses
 

  • Biomarkers (specify)
  • Metabolomics

6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking