Date of filling in this questionnaire or last update: 23/09/2020
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  SwedSweeps
Country
 

  • Sweden

Please provide any other information on the cohort location/s if needed
  Southern Sweden
Name
  Karin Broberg
Institution
  Karolinska Institutet/Lund University
Email
  karin.broberg@ki.se
Phone
  +46737823750
Personal website
  https://staff.ki.se/people/karbro
Name of committee
  Regional Ethics Committee Lund, Sweden
Upload files
 

Contact Principal Investigator (name)
  Karin Broberg
Data access policy (briefly describe)
  Other researchers can contact PI for access to data. The research aims should be in line with the ethical approval.
Main aim of cohort, please briefly describe the main objectives of the cohort
  To evaluate risk of cancer and cardiovascular disease among working chimney sweeps.
Study design (please select as many as appropriate)
 

  • Other

Specify: Other
  Cross-sectional study of chimney sweeps and workers not occupationally exposed to PAH
Source population (please select as many as appropriate)
 

  • Industry / occupation-based

Comparators (please select as many as appropriate)
 

  • External comparison of workers with other exposure

Inclusion criteria
  male, 18-65 years
Exclusion criteria
  female
Enrollment
  Completed
Age range at entry (main cohort)
 

Minimum Maximum Mean
19 66 43

Men at enrollment
  300
Women at enrollment
  0
Children (<18 years) at enrollment
  0
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Other (specify)

Specify: Other
 

  • Biomarkers of disease, blood pressure

3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
  • Environmental samples

Occupational history/time frame
  Longest
Occupational coding performed
  No
Types of exposure measurements
 

  • Biomarkers (see also section 5)

Methods for exposure assessment (please select as many as appropriate)
 

  • Expert assessment
  • Measurements (external sampling, biomarkers)

Main categories
 

  • Other chemicals

Other chemicals | Engine exhaust
 

  • Diesel engine exhaust

Other chemicals | Polycyclic aromatic hydrocarbons (PAHs)
 

  • Benzo(a)pyrene
  • Soot

Comments
  Metabolites of different PAH in urine, including BaP.
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Questionnaire, individual (self-recording or interview)

Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  Blood pressure
Specify: Biomarker
  Cancer- and CVD-related proteins and risk markers, genetic and epigenetic biomarkers
Diagnostic groups based on ICD10
 

  • C + D Neoplasms
  • I Heart disease
  • I Cerebrovascular diseases
  • J Respiratory disease

C + D Neoplasms
 

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia

I Heart disease
 

  • Rheumatic heart disease, unspecified
  • Hypertensive diseases
  • Angina pectoris
  • Acute myocardial infarction
  • Atrial septal defect
  • Chronic ischaemic heart disease
  • Pulmonary embolism
  • Other pulmonary heart diseases
  • Nonrheumatic mitral valve disorders
  • Pulmonary valve disorders
  • Endocarditis
  • Myocarditis
  • Cardiomyopathy
  • Atrioventricular arrhythmia
  • Heart failure

I Cerebrovascular diseases
 

  • Subarachnoid haemorrhage
  • Intracerebral haemorrhage
  • Cerebral infarction
  • Stroke, not specified as haemorrhage or infarction
  • Atherosclerosis
  • Aneurysm and dissection
  • Raynaud's syndrome
  • Thromboangiitis obliterans [Buerger]
  • Arterial embolism and thrombosis
  • Phlebitis and thrombophlebitis
  • Haemorrhoids
  • Oesophageal varices
  • Varicose veins of other sites
  • Lymphadenitis
  • Hypotension

J Respiratory disease
 

  • Acute upper respiratory infections of multiple and unspecified sites
  • Influenza
  • Viral pneumonia
  • Bacterial pneumonia
  • Pneumonia due to other infectious organisms, not elsewhere classified
  • Abscess of lung and mediastinum
  • Pyothorax
  • Acute bronchitis
  • Acute bronchiolitis
  • Vasomotor and allergic rhinitis
  • Chronic rhinitis, nasopharyngitis and pharyngitis
  • Chronic sinusitis
  • Nasal polyp
  • Chronic diseases of tonsils and adenoids
  • Diseases of vocal cords and larynx, not elsewhere classified
  • Chronic Bronchitis
  • Emphysema
  • Chronic obstructive pulmonary disease (COPD)
  • Asthma
  • Byssinosis
  • Bronchiectasis
  • Pneumoconiosis
  • Hypersensitivity pneumonitis due to organic dust
  • Other interstitial lung disease
  • Adult respiratory distress syndrome
  • Pulmonary edema
  • Pneumothorax
  • Respiratory failure, not elsewhere classified

Other health related outcomes
 

  • Biomarkers

5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
  • Urine
  • Other

Specify: Other
  Mouth wash
Biological processing
 

  • DNA

Genetic and other lab analyses
 

  • Biomarkers (specify)
  • Epigenomics
  • Genomics / Other genetics (specify)
  • Proteomics

Specify: Biomarkers
  Ox stress markers, e.g. 8oxodG
Specify: Other genetics
  Telomere length, mitochondrial DNA copy number and methylation
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Physical exercise
  • Residential history
  • Smoking

Specify: Environmental other
  Hobby exposure to PAH
Possibility for linkage to data registries/data enrichment via data linkage
 

  • Cancer incidence
  • Employment status
  • Hospital discharge
  • Medication usage
  • Mortality register