| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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Viking Genes
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Country
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Please provide any other information on the cohort location/s if needed
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The VIKING II cohort, part of Viking Genes, is recruiting worldwide as it is an online plus "spit-and-post" study.
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Name
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James Flett Wilson
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Institution
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University of Edinburgh
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Email
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jim.wilson@ed.ac.uk
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Personal website
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https://www.ed.ac.uk/profile/jim-wilson
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Website
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- https://www.ed.ac.uk/viking
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Name of committee
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South East Scotland REC, NHS Lothian
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Upload files
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Contact Principal Investigator (name)
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Prof Jim F. Wilson
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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Isolate populations with high kinship; aims to discover the genes and variants that influence the risk of common, complex diseases.
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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- General population: Regional
- Generation (parents-children) study
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Comparators (please select as many as appropriate)
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- External study population (includes SMR/SIR studies)
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Inclusion criteria
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Aged over 16; two or more grandparents from Orkney or Shetland
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Exclusion criteria
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Under 16 years, one or fewer grandparents from Northern isles of Scotland
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Enrollment
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Ongoing
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
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none |
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Men at enrollment
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4,000 (expected)
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Women at enrollment
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4,000 (expected)
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Children (<18 years) at enrollment
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Approx 100 (expected)
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Comments
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We're merging aspects of the completed ORCADES study with the completed Viking health Study Shetland, collectively "VIKING". We aim to recruit a further 4,000 volunteers with ancestry (two or more grandparents) from Orkney or the Shetland Isles in "VIKING II".
This new VIKING II recruitment will take the total number of participants in Viking Genes to 8,000
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Disease incidence records
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Disease incidence records (specify)
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- NHS Electronic health records, including the SMR01 (Scottish Morbidity Record) database of hospitalisation codes
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Comments
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The EHR dataset is updated on request. Nearly 100% of participants are linked or will be linked to these records for longitudinal follow-up.
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
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Occupational history/time frame
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Current, at enrollment
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Occupational coding performed
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No
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Types of exposure measurements
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- Biomarkers (see also section 5)
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Methods for exposure assessment (please select as many as appropriate)
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Medical records
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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Range of measures at enrolment inc spirometry, ECGs
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Specify: Biomarker
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Proteomics, metabolomics, genomics
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Follow-up - type of outcome data collected (select more than one if applicable)
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Outcome type (please select as many as appropriate)
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Biological processing
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Genetic and other lab analyses
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- Genomics / GWAS
- Genomics / Other genetics (specify)
- Metabolomics
- Proteomics
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Specify: Other genetics
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Exome sequence
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| 6. Other Information |
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Possibility for linkage to data registries/data enrichment via data linkage
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- Cancer incidence
- Medication usage
- Mortality register
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