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Date of filling in this questionnaire or last update: 27/07/2020
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  INMA-Environment and Childhood Project
Country
 

  • Spain
Please provide any other information on the cohort location/s if needed
  Ribera d'Ebre, Menorca, Granada, Valencia, Sabadell, Asturias, Gipuzkoa
Name
  Mònica Guxens
Institution
  ISGlobal (Barcelona Institute for Global Health)
Email
  monica.guxens@isglobal.org
Name
  Maribel Casas
Institution
  ISGlobal (Barcelona Institute for Global Health)
Email
  maribel.casas@isglobal.org
Website
 

  • https://www.proyectoinma.org/
Name of committee
  Ethical committees of the centres involved in the study
Upload files
 

Or provide website
 

  • https://www.proyectoinma.org/
Contact Principal Investigator (name)
  Susana Gros (project manager) - inma@proyectoinma.org
Data access policy (briefly describe)
  Researchers who have an interest in using data for research purposes can apply for access to data. Any delivery of data will be considered as a sub-project in INMA Project. The applicant has to be affiliated with an institution with competence in conducting research projects that is willing to be responsible for a sub-project. Inexperienced researchers must have a scientific supervisor belonging to such an institution. All sub-projects must have a principal investigator with scientific responsibility for the project. For each sub-project, a contract will be signed. To apply for access to data in INMA Project, the electronic application system for this project should be used. Our “Application for external collaboration. Data analysis request form“ should be used. All applications should be sent to inma@proyectoinma.org. More information about access to the data can be found on our website (www.proyectoinma.org) under “INMA Collaboration policy” (left screen menu, bottom) in the “INMA Project” section.
Upload files
 

Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
  INMA-Environment and Childhood is a research network of several Spanish groups that created a project with the aim to study the paper of the more relevant environmental pollutants in the air, water and diet during the pregnancy and beginning of life, and their effects in the growth and development.
Study design (please select as many as appropriate)
 

  • Prospective cohort
Source population (please select as many as appropriate)
 

  • General population: Regional
  • Mother-child cohort
Comparators (please select as many as appropriate)
 

  • Internal study population
Inclusion criteria
  -To belong to the study area (specific of each cohort). -To be minimum 16 years. -To have a unique pregnancy. -Not to have followed any program of assisted reproduction. -To give birth in the reference hospital. -Not to have communication problems.
Exclusion criteria
  -Twins Exclusion: to belong to the study area (specific of each cohort) - Exclusion: to be minimum 16 years - Exclusion: to have a unique pregnancy - Exclusion: not to have followed any program of assisted reproduction - Exclusion: to give birth in the reference hospital - Exclusion: not to have communication problems
Enrollment
  Completed
Age range at entry (main cohort)
 

Minimum Maximum Mean
16 44 30

Men at enrollment
  -
Women at enrollment
  3174
Children (<18 years) at enrollment
  -
Men at last follow-up
  -
Women at last follow-up
  -
Children (<18 years) at last follow-up
  2240 (12-14 years)
Participation rate at enrollment (if known)
  70
Comments
  From 45% to 98% of the eligible pregnant women agreed to participate (96% in Ribera d’Ebre, 98% in Menorca, 54% in Valencia, 60% in Sabadell, 45% in Asturias and 68% in Gipuzkoa; information
not available for Granada).
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Active (contact with participants)
Active (contact with participants) (specify)
 

  • Parental occupational information is collected in the different follow-ups of the offspring
First follow-up period (provide year)
  1997
Last follow-up period (provide year)
  2020
Number of follow-ups after baseline (provide number)
  6
Participation at last follow-up (if known)
  56
Comments
  The main 6 follow-ups of the INMA children have been at 1.5, 4, 7, 9, 12, and at 14 years (ongoing).
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)
Occupational history/time frame
  Current, at enrollment
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • ISCO-88, CNO-94, CNAE-93
Industry (specify coding system used)
 

  • ISIC 1971
Types of exposure measurements
 

  • Biomarkers (see also section 5)
  • Personal external sampling
Methods for exposure assessment (please select as many as appropriate)
 

  • Data modelling
  • GIS (other spatial methods)
  • Job Exposure Matrix
  • Measurements (external sampling, biomarkers)
  • Self-report
 

  • ELF-MF JEM
Please insert reference/further information
  Bowman JD, Touchstone JA, Yost MG. A Population-Based Job Exposure Matrix for Power-Frequency Magnetic Fields. J Occup Environ Hyg. 2007;4(9):715-728. doi:10.1080/15459620701528001 (modified version)
 

  • Other
Specify: Job Exposure Matrix / Other
  Endocrine disruptors (Brouwers MM, van Tongeren M, Hirst AA, Bretveld RW, Roeleveld N. 2009. Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix. Occup Environ Med 66:607–614)
Main categories
 

  • Solvents
  • Pesticides
  • Metals and metal oxides
  • Other chemicals
  • Physical agents
  • Ergonomics, physical workload, and injury related
Solvents | Aromatic hydrocarbon solvents
 

  • Benzene
Metals and metal oxides
 

  • Arsenic all types
  • Cadmium and all compounds
  • Lead and all compounds
  • Mercury, organic, inorganic
  • Nickel and all compounds
Other chemicals | Acrylamide
 

  • Acrylamide
Other chemicals | Flame retardants
 

  • Flame retardants
Other chemicals | Second hand tobacco smoke at work
 

  • Second hand tobacco smoke at work (Environmental tobacco smoke - ETS)
Physical agents
 

  • Cold
  • Hand-arm vibration
  • Heat
  • Noise
  • Radiation
Physical agents | Radiation
 

  • Ionising
Ergonomics, physical workload, and injury related
 

  • Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
  • Standing work
Comments
  Work exposure questionnaire administered during pregnancy: https://www.proyectoinma.org/wp-content/uploads/2018/06/100.v2exposicionlaboraluk_editora_16_542_1.pdf
Metals, acrylamide, flame retardants, phthalates, PCBs, DDT, PFASs have been determined in biological samples during pregnancy.
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Questionnaire, individual (self-recording or interview)
Specify: Biomarker
  Isoprostane, iodine, creatinine, triglycerides, cholesterol, folic acid, vitamins, thyroid hormones,C-reactive protein, IgEs, fatty acids, albumin,
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Questionnaire, individual (self-recording or interview)
Other health related outcomes
 

  • Lifestyle change
  • Quality of life/wellbeing
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
  • Nails
  • Urine
  • Other
Specify: Other
  breast milk, placenta
Biological processing
 

  • DNA
Genetic and other lab analyses
 

  • Genomics / Other genetics (specify)
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking
Specify: Environmental other
  Noise, built environment, green spaces
Please describe plans that are funded or most likely to be funded
  The follow-up of children at 15 years is ongoing in the cohorts of Valencia, Sabadell, and Gipuzkoa.