Date of filling in this questionnaire or last update: 27/07/2020
Cohort name
  INMA-Environment and Childhood Project

  • Spain

Please provide any other information on the cohort location/s if needed
  Ribera d'Ebre, Menorca, Granada, Valencia, Sabadell, Asturias, Gipuzkoa
  Mònica Guxens
  ISGlobal (Barcelona Institute for Global Health)
  Maribel Casas
  ISGlobal (Barcelona Institute for Global Health)


Name of committee
  Ethical committees of the centres involved in the study
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Contact Principal Investigator (name)
  Susana Gros (project manager) -
Data access policy (briefly describe)
  Researchers who have an interest in using data for research purposes can apply for access to data. Any delivery of data will be considered as a sub-project in INMA Project. The applicant has to be affiliated with an institution with competence in conducting research projects that is willing to be responsible for a sub-project. Inexperienced researchers must have a scientific supervisor belonging to such an institution. All sub-projects must have a principal investigator with scientific responsibility for the project. For each sub-project, a contract will be signed. To apply for access to data in INMA Project, the electronic application system for this project should be used. Our “Application for external collaboration. Data analysis request form“ should be used. All applications should be sent to More information about access to the data can be found on our website ( under “INMA Collaboration policy” (left screen menu, bottom) in the “INMA Project” section.
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Participation in pooled analyses

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).

Main aim of cohort, please briefly describe the main objectives of the cohort
  INMA-Environment and Childhood is a research network of several Spanish groups that created a project with the aim to study the paper of the more relevant environmental pollutants in the air, water and diet during the pregnancy and beginning of life, and their effects in the growth and development.
Study design (please select as many as appropriate)

  • Prospective cohort

Source population (please select as many as appropriate)

  • General population: Regional
  • Mother-child cohort

Comparators (please select as many as appropriate)

  • Internal study population

Inclusion criteria
  -To belong to the study area (specific of each cohort). -To be minimum 16 years. -To have a unique pregnancy. -Not to have followed any program of assisted reproduction. -To give birth in the reference hospital. -Not to have communication problems.
Exclusion criteria
  -Twins Exclusion: to belong to the study area (specific of each cohort) - Exclusion: to be minimum 16 years - Exclusion: to have a unique pregnancy - Exclusion: not to have followed any program of assisted reproduction - Exclusion: to give birth in the reference hospital - Exclusion: not to have communication problems
Age range at entry (main cohort)

Minimum Maximum Mean
16 44 30

Men at enrollment
Women at enrollment
Children (<18 years) at enrollment
Men at last follow-up
Women at last follow-up
Children (<18 years) at last follow-up
  2240 (12-14 years)
Participation rate at enrollment (if known)
  From 45% to 98% of the eligible pregnant women agreed to participate (96% in Ribera d’Ebre, 98% in Menorca, 54% in Valencia, 60% in Sabadell, 45% in Asturias and 68% in Gipuzkoa; information
not available for Granada).
Type of data for outcome follow-up (please select as many as appropriate)

  • Active (contact with participants)

Active (contact with participants) (specify)

  • Parental occupational information is collected in the different follow-ups of the offspring

First follow-up period (provide year)
Last follow-up period (provide year)
Number of follow-ups after baseline (provide number)
Participation at last follow-up (if known)
  The main 6 follow-ups of the INMA children have been at 1.5, 4, 7, 9, 12, and at 14 years (ongoing).
Source of exposure data collected (please select as many as appropriate)

  • Questionnaire, Personal (Self-reporting or interview)

Occupational history/time frame
  Current, at enrollment
Occupational coding performed
Occupation (specify coding system used)

  • ISCO-88, CNO-94, CNAE-93

Industry (specify coding system used)

  • ISIC 1971

Types of exposure measurements

  • Biomarkers (see also section 5)
  • Personal external sampling

Methods for exposure assessment (please select as many as appropriate)

  • Data modelling
  • GIS (other spatial methods)
  • Job Exposure Matrix
  • Measurements (external sampling, biomarkers)
  • Self-report



Please insert reference/further information
  Bowman JD, Touchstone JA, Yost MG. A Population-Based Job Exposure Matrix for Power-Frequency Magnetic Fields. J Occup Environ Hyg. 2007;4(9):715-728. doi:10.1080/15459620701528001 (modified version)

  • Other

Specify: Job Exposure Matrix / Other
  Endocrine disruptors (Brouwers MM, van Tongeren M, Hirst AA, Bretveld RW, Roeleveld N. 2009. Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix. Occup Environ Med 66:607–614)
Main categories

  • Solvents
  • Pesticides
  • Metals and metal oxides
  • Other chemicals
  • Physical agents
  • Ergonomics, physical workload, and injury related

Solvents | Aromatic hydrocarbon solvents

  • Benzene

Metals and metal oxides

  • Arsenic all types
  • Cadmium and all compounds
  • Lead and all compounds
  • Mercury, organic, inorganic
  • Nickel and all compounds

Other chemicals | Acrylamide

  • Acrylamide

Other chemicals | Flame retardants

  • Flame retardants

Other chemicals | Second hand tobacco smoke at work

  • Second hand tobacco smoke at work (Environmental tobacco smoke - ETS)

Physical agents

  • Cold
  • Hand-arm vibration
  • Heat
  • Noise
  • Radiation

Physical agents | Radiation

  • Ionising

Ergonomics, physical workload, and injury related

  • Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
  • Standing work

  Work exposure questionnaire administered during pregnancy:
Metals, acrylamide, flame retardants, phthalates, PCBs, DDT, PFASs have been determined in biological samples during pregnancy.
Baseline - type of outcome data collected (select more than one if applicable)

  • Biomarker (specify)
  • Questionnaire, individual (self-recording or interview)

Specify: Biomarker
  Isoprostane, iodine, creatinine, triglycerides, cholesterol, folic acid, vitamins, thyroid hormones,C-reactive protein, IgEs, fatty acids, albumin,
Follow-up - type of outcome data collected (select more than one if applicable)

  • Questionnaire, individual (self-recording or interview)

Other health related outcomes

  • Lifestyle change
  • Quality of life/wellbeing

Biological samples collected

  • Blood
  • Nails
  • Urine
  • Other

Specify: Other
  breast milk, placenta
Biological processing

  • DNA

Genetic and other lab analyses

  • Genomics / Other genetics (specify)

6. Other Information

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental, air pollution
  • Environmental other (specify)
  • Medical history
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking

Specify: Environmental other
  Noise, built environment, green spaces
Please describe plans that are funded or most likely to be funded
  The follow-up of children at 15 years is ongoing in the cohorts of Valencia, Sabadell, and Gipuzkoa.