Date of filling in this questionnaire or last update: 22/09/2020
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  The Tromsø Study (Tromsøundersøkelsen)
Country
 

  • Norway

Please provide any other information on the cohort location/s if needed
  Tromsø
Name
  Sameline Grimsgaard
Institution
  UiT The Arctic University of Norway
Email
  sameline.grimsgaard@uit.no
Phone
  +47 913 51 858
Personal website
  https://uit.no/ansatte/person?p_document_id=42072
Name
  Anje Christina Höper
Institution
  UiT The Arctic University of Norway
Email
  anje.hoeper@uit.no
Phone
  +47 98022451
Personal website
  https://uit.no/ansatte/person?p_document_id=631899
Website
 

  • https://en.uit.no/forskning/forskningsgrupper/gruppe?p_document_id=453582

Name of committee
  Regional committees for medical and health research ethics
Or provide website
 

  • https://en.uit.no/forskning/forskningsgrupper/gruppe?p_document_id=453582
  • https://uit.no/forskning/forskningsgrupper/sub?p_document_id=367276&sub_id=388740
  • https://en.uit.no/forskning/forskningsgrupper/sub?p_document_id=453582&sub_id=91821

Contact Principal Investigator (name)
  Sameline Grimsgaard
Data access policy (briefly describe)
  Projects that apply for data from the Tromsø Study must follow the EU’s Privacy Regulation (GDPR) and the Norwegian Personal Data Act by providing a basis for process. Furthermore, the connected research institute must consider the need to conduct a Data Protection Impact Assessment (DPIA). After approval from one of the Regional Committees for medical and health research ethics in Norway, application for research data is to be sent to tromsous@uit.no. Available variables er listet here: http://tromsoundersokelsen.uit.no/tromso/. For further details regarding application of data access see https://en.uit.no/forskning/forskningsgrupper/sub?p_document_id=453582&sub_id=669706
Is this cohort part of a consortium? (name consortium)
  participates in international MORGAM (MONICA risk genetics archiving and monograph), BIOMARCARE , ERFC (Emerging risk factors collaboration), GBD (Global burden of disease) and national consortiums NCD (non-communicable diseases Norway), CONOR (Cohort Norway) with parts of their data
Participation in pooled analyses
 

  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).

Main aim of cohort, please briefly describe the main objectives of the cohort
  The Tromsø Study is a general population study. Its primary aim was initially to determine the reasons for the high mortality of cardiovascular disease, and also to develop ways of preventing heart attacks and strokes. The study was gradually expanded to include many other diseases, such as rheumatism, neurological and mental diseases, skin diseases, stomach and bowel-related diseases, cancer and osteoporosis. The health study has been repeated at regular intervals and involves a large proportion of the municipality's population. The study is a combination of questionnaires and physical examination data. It has so far had seven waves, the first in 1974, the 7th in 2015/2016. The waves vary in terms of participants and content, so that the following information is held general, for details, please consult the webpages or contact the PI.
Study design (please select as many as appropriate)
 

  • Prospective cohort
  • Retrospective cohort
  • Nested case-control / Case-cohort
  • Intervention study

Source population (please select as many as appropriate)
 

  • General population: Regional

Comparators (please select as many as appropriate)
 

  • Internal study population
  • External comparison of workers with other exposure

Inclusion criteria
  Residents of Tromsø municipality, different ages depending on wave
Enrollment
  Ongoing
Age range at entry (main cohort)
 

Minimum Maximum Mean
(12) 20 for adults 97 depending on wave

Men at last follow-up
  10009
Women at last follow-up
  11074
Children (<18 years) at last follow-up
  0
Comments
  For the seven waves so far, a total of 45 473 different people have participated in at least one of the seven studies, while 18 510 have participated on three or more occasions. 737 men have attended seven times, and 1236 women have attended six times. The more detailed description of the design of The Tromsø Study is given in a Cohort Profile paper.

Participation rates ranged from 62,4-81,8% depending on wave and gender, for more detailed information see websites mentioned above.

2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Active (contact with participants)
  • Death certificate
  • Disease incidence records
  • Hospital / physician diagnoses
  • Use of registers (specify)

Active (contact with participants) (specify)
 

  • Follow-up surveys aboute once a decade

Death certificate (specify)
 

  • Norwegian Cause of Death Registry

Disease incidence records (specify)
 

  • Different national disease/quality registers

Hospital / Physician diagnoses (specify)
 

  • Norwegian Patient Register

Specify: Use of registers
 

  • The study can link to different national registers, such as The Cancer registry of Norway, the Norwegian Prescription Database (NorPD), the Medical Birth Registry of Norway, Patient record based endpoint register (University Hospital North Norway),etc

First follow-up period (provide year)
  1974
Last follow-up period (provide year)
  2016
Number of follow-ups after baseline (provide number)
  45 473
Participation at last follow-up (if known)
  65
Comments
  see earlier comment
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Questionnaire, Personal (Self-reporting or interview)

Occupational history/time frame
  Follow-up period
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • For parts of the 6th wave there are occupational codes available

Types of exposure measurements
 

  • Biomarkers (see also section 5)

Methods for exposure assessment (please select as many as appropriate)
 

  • Self-report

Main categories
 

  • Ergonomics, physical workload, and injury related
  • Other (specify)

Ergonomics, physical workload, and injury related
 

  • Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
  • Sedentary work
  • Standing work

Main categories | Other | Specify: Other
  work in the cold, work with vibrating tools, noise
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Death certificates
  • Medical records
  • Questionnaire, individual (self-recording or interview)
  • Registry-based

Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  depending on wave - check database
Specify: Biomarker
  depending on wave - check database
Registry-based
 

  • Cancer incidence
  • Employment status
  • Mortality register
  • Other

Specify: Other
  Occupational code from State Register of Employers and Employees
Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Death certificates
  • Medical records
  • Questionnaire, individual (self-recording or interview)
  • Registry-based

Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  depending on wave - check database
Specify: Biomarker
  depending on wave - check database
Registry-based
 

  • Cancer incidence
  • Mortality register

Outcome type (please select as many as appropriate)
 

  • Mortality
  • Morbidity

Diagnostic groups based on ICD10
 

  • E Endocrinological disease
  • E Malnutrition and obesity
  • E Metabolism disease
  • H Disorders of the eye
  • I Heart disease
  • I Cerebrovascular diseases
  • K Diseases of oral cavity, salivary glands and jaws
  • L Skin, nail and hair disorders
  • N Kidney, renal pelvis disease

Other health related outcomes
 

  • Quality of life/wellbeing
  • Other (specify)

Specify: Other
  pain
Comments
  For more details, please see www.tromsoundersokelsen.no
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
  • Urine
  • Other

Specify: Other
  feces
Biological processing
 

  • DNA

Genetic and other lab analyses
 

  • Genomics / GWAS

Comments
  For further information, contact PI.
6. Other Information
 

  • Alcohol
  • Anthropometry
  • Demographics
  • Diet
  • Education
  • Environmental other (specify)
  • Medical history
  • Personality
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking

Specify: Environmental other
  noise
Possibility for linkage to data registries/data enrichment via data linkage
 

  • Birth register
  • Cancer incidence
  • Disease specific clinical database
  • Employment status
  • Hospital discharge
  • Medication usage
  • Mortality register
  • Other (specify)

Specify: Other
  State Register of Employers and Employees (AA-register - occupational codes and employment status) ; National register of control and health service refunds (KUHR database), disease registries etc
Please describe plans that are funded or most likely to be funded
  Mortality and cancer incidence is automatically linked, others have to be applied for.