2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   DOC*X Country   Denmark Name   Esben Meulengracht Flachs Institution   Bispebjerg and Frederiksberg Hospital, University of Copenhagen Email   esben.meulengracht.flachs@regionh.dk Do you want to add another Principal Investigator of the Cohort   Add another Principal Investigator of the cohort Name   Camilla Sandal Sejbæk Institution   Bispebjerg and Frederiksberg Hospital, University of Copenhagen Email   camilla.sandal.sejbaek@regionh.dk Website   www.doc-x.dk Name of committee   Danish National Committee on Health Research Ethics Or provide website   www.doc-x.dk Contact Principal Investigator (name)   Esben Meulengracht Flachs Data access policy (briefly describe)   Data is available through collaboration with a participating institution with affiliation to the Research Server at Statistics Denmark Is this cohort part of a consortium? (name consortium)   The European Occupational Exposome and Health Cohort Consortium Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Main aim of cohort, please briefly describe the main objectives of the cohort   A large nationwide database that can integrate prospective data on occupational exposures with data on health, work participation and labour market exit Study design (please select as many as appropriate)   Prospective cohort Source population (please select as many as appropriate)   General population: National Mother-child cohort Generation (parents-children) study Comparators (please select as many as appropriate)   Internal study population External comparison of workers with other exposure Inclusion criteria   Persons aged at least 16 years who were gainfully employed and living in Denmark in 1970 or from 1976 to 2022 Enrollment   Ongoing Age range at entry (main cohort)   Minimum Maximum Mean 16 105 35 Men at enrollment   2,984,000 Women at enrollment   2,414,000 Children (<18 years) at enrollment   2,460,000 Men at last follow-up   2,984,000 Women at last follow-up   2,414,000 Children (<18 years) at last follow-up   2,460,000 Participation rate at enrollment (if known)   95 Comments   In 2015 the cohort included 6,399,000 individuals - 2,984,000 men and 2,414,000 women. JEM based exposures in the database: - Psychosocial exposures (permission needed from JEM owners) - Shoulder exposures (upper arm elevation, repetitive shoulder movements, forceful shoulder exertions) - Lower body exposures (total load lifted, standing/walking, sitting, kneeling/squatting) - Physical exertion and body position (score based on sitting, standing/walking, kneeling, repetition, twisted back, lifted arms, lifting/carrying, pushing/pulling) - Noise - Vibration - Particulate airborne exposures (mineral dust, organic dust, fumes and vapour) (permission needed from JEM owners) - Wood and endotoxin - Chemical agents (permission needed from JEM owners) - Lifestyle (tobacco smoking, body mass index, alcohol consumption, leisure-time physical activity, fruit/vegetables consumption) - Wet hands and gloves 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Death certificate Disease incidence records Hospital / physician diagnoses Use of registers (specify) Death certificate (specify)   Access to Cause of Death register Disease incidence records (specify)   Access to the Danish Patient Registry Hospital / Physician diagnoses (specify)   ICD-8 or ICD-10 codes First follow-up period (provide year)   1976 Last follow-up period (provide year)   2022 Number of follow-ups after baseline (provide number)   Once per year Participation at last follow-up (if known)   95 Comments   The generational part of the DOC*X cohort, DO*X-G, contains: Women with at least one pregnancy: 1,414,000 Men with at least one child: 1,244,305 3,433,000 pregnancy outcomes of women in the cohort, includes both induced and spontaneous abortions, still- and liveborn children. 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Job-employment records Occupational history/time frame   Follow-up period Occupational coding performed   Yes Occupation (specify coding system used)   DISCO-88 (Danish version of ISCO-88) Industry (specify coding system used)   DB-07 (Danish version of NACE v.2) Methods for exposure assessment (please select as many as appropriate)   Job Exposure Matrix   ALOHA+ JEM Please insert reference/further information   Permission needed from owners   BEN-JEM   Endotoxin QJEM   Lifestyle JEM (DK)   Light JEM (DK)   NOCCA JEM   Noise JEM (DK)   Psyk JEM   SYN-JEM   Wood DUST QJEM Main categories   Dusts and fibres Solvents Pesticides Metals and metal oxides Other chemicals Biological factors Ergonomics, physical workload, and injury related Psychosocial domains 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Death certificates Medical records Registry-based Registry-based   Birth register Disease specific clinical database Hospital discharge Mortality register Migration Follow-up - type of outcome data collected (select more than one if applicable)   Death certificates Medical records Registry-based Registry-based   Birth register Employment status Hospital discharge Mortality register Migration Outcome type (please select as many as appropriate)   Mortality Morbidity Disability Diagnostic groups based on ICD10   A Bacterial infectious disease, type of microorganisms* B Viral infections, type of microorganisms* B99 Other and unspecified infectious diseases, type of microorganisms* C + D Neoplasms D Diseases of blood and blood-forming organs excl. leukemia E Endocrinological disease E Malnutrition and obesity E Metabolism disease F Mental disorders G Disease in the nervous system H Disorders of the eye H Disorders of the ear I Heart disease I Cerebrovascular diseases J Respiratory disease K Diseases of oral cavity, salivary glands and jaws K Diseases of oesophagus, stomach, duodenum and appendix K Hernia, colon and intestine disease K Diseases of peritoneum, liver L Skin, nail and hair disorders M Arthritis, arthrosis, systemic connective disorders, spine disorders M Disorders of muscles, bones, synovialis, bursa, cartilage N Kidney, renal pelvis disease N Male and female related disorders O+P Pregnancy and labour Q After birth – child disorders S Injuries Other health related outcomes   Work participation 6. Other Information   Alcohol Demographics Diet Education Medical history Physical exercise Residential history Socioeconomic status Smoking Possibility for linkage to data registries/data enrichment via data linkage   Birth register Employment status Hospital discharge Migration Mortality register Please describe plans that are funded or most likely to be funded   Exposure to air pollution