| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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COBRA: Risk of COVID-19 in health care workers in Denmark
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Country
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Name
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Henrik Kolstad
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Institution
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Aarhus University Hospital
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Email
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henkol@rm.dk
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Phone
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4529610359
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Name of committee
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Ethics approval not required in Denmark for a questionnaire-register linkage study as this
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Contact Principal Investigator (name)
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Henrik Kolstad
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Data access policy (briefly describe)
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Data will be uploaded with the National Health Data Authority and access to pseudonymized data will be possible through the principal investigator
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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Analyze the risk of SARS-CoV-2 infection and COVID-19 disease in health care workers and the effect of protective equipment and procedures
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Study design (please select as many as appropriate)
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Source population (please select as many as appropriate)
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- Industry / occupation-based
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Comparators (please select as many as appropriate)
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- Internal study population
- External comparison of workers with other exposure
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Inclusion criteria
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Employed April 2020 in hospitals in Central Denmark or Capitol Region of Denmark
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Exclusion criteria
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None
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Enrollment
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Ongoing
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 18 |
70 |
40 |
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Age range at entry (subcohort)
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| Minimum |
Maximum |
Mean |
Please describe |
| 18 |
70 |
40 |
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Men at enrollment
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4000
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Women at enrollment
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16 000
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Children (<18 years) at enrollment
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0
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Men at last follow-up
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4000
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Women at last follow-up
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16000
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Children (<18 years) at last follow-up
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0
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Participation rate at enrollment (if known)
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45
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Disease incidence records
- Use of registers (specify)
- Other (specify)
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Active (contact with participants) (specify)
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- Daily symptoms of respiratory infection
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Disease incidence records (specify)
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- National patient register
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Specify: Use of registers
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- National registers on hospital contacts, redeemed medications, members of the household
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Specify: Other
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- Swab and serology on SARS-CoV-2 from ongoint surveillance program
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First follow-up period (provide year)
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April 24, 2020
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Last follow-up period (provide year)
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June 30, 2020
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Number of follow-ups after baseline (provide number)
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68
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Participation at last follow-up (if known)
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80
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Industry-based questionnaire
- Job-employment records
- Registry-based
- Job calendar
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Occupational history/time frame
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Current, at enrollment
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Occupational coding performed
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Yes
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Occupation (specify coding system used)
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Industry (specify coding system used)
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Methods for exposure assessment (please select as many as appropriate)
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- Job Exposure Matrix
- Self-report
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Specify: Job Exposure Matrix / Other
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COBRA-JEM will be developed for exposure characterization of non-responders
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Main categories
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Biological factors | Viruses
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Biological factors | Viruses | Specify: Other
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SARS-CoV-2
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Biomarker
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SARS-CoV-2 PCR and Ab
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Biomarker
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SARS-CoV-2 PCR and Ab
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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- B Viral infections, type of microorganisms*
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B Viral infections, type of microorganisms
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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| 6. Other Information |
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- Anthropometry
- Education
- Smoking
- Other (specify)
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Specify: Other
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PPE
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Possibility for linkage to data registries/data enrichment via data linkage
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- Cancer incidence
- Disease specific clinical database
- Employment status
- Hospital discharge
- Medication usage
- Migration
- Mortality register
- Other (specify)
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Specify: Other
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House hold members
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