2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   Cohort of Workers Exposed to Ethylene Oxide Country   United States Name   Kaitlin Kelly-Reif Institution   National Institute for Occupational Safety and Health Email   omp3@cdc.gov Website   https://www.cdc.gov/niosh/pgms/worknotify/ethyleneoxide.html Upload files   Stayner-1993-AJE.pdf Contact Principal Investigator (name)   Please contact NIOSH by submitting the attached form Upload files   OMEGANET-cohort-interest-form.docx Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Main aim of cohort, please briefly describe the main objectives of the cohort   Estimate the association between occupational exposure to ethylene oxide and causes of death Study design (please select as many as appropriate)   Retrospective cohort Comparators (please select as many as appropriate)   Internal study population External study population (includes SMR/SIR studies) Inclusion criteria   Potential exposure to ethylene oxide through employment at one of 14 US plants producing sterilized medical supplies and spices Enrollment   Completed Men at enrollment   8,214 Women at enrollment   10,039 Children (<18 years) at enrollment   0 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Death certificate Death certificate (specify)   Mortality is currently being updated though 2018 First follow-up period (provide year)   1987 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Job-employment records Occupational history/time frame   Follow-up period Occupational coding performed   No Types of exposure measurements   Workplace sampling Methods for exposure assessment (please select as many as appropriate)   Data modelling Job Exposure Matrix Main categories   Other chemicals Other chemicals | Ethylene oxide   Ethylene oxide 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Death certificates Follow-up - type of outcome data collected (select more than one if applicable)   Death certificates Medical records Questionnaire, individual (self-recording or interview) Outcome type (please select as many as appropriate)   Mortality Morbidity Diagnostic groups based on ICD10   C + D Neoplasms C + D Neoplasms   Benign neoplasm Carcinoma in situ Leukemia Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas Malignant neoplasm lung Mesothelioma Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura Malignant neoplasm of bone and articular cartilage Melanoma and other malignant neoplasms of skin Neoplasms connective and soft tissue including nerves Malignant neoplasm of breast Malignant neoplasms, females gynecological Malignant neoplasms of male genital organs Malignant neoplasm of urinary tract and kidney Malignant neoplasms of eye, brain and other parts of central nervous system Malignant neoplasms of thyroid and other endocrine glands Malignant neoplasms of ill-defined, secondary and unspecified sites Malignant neoplasm without specification of site including excl. leukemia Other, please state 6. Other Information Possibility for linkage to data registries/data enrichment via data linkage   Cancer incidence Mortality register