Date of filling in this questionnaire or last update: 22/03/2021
1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Workers biologically monitored (solvents)
Country
 

  • Finland

Name
  Sanni Uuksulainen
Institution
  Finnish Institute of Occupational Health
Email
  Sanni.Uuksulainen@ttl.fi
Contact Principal Investigator (name)
  Sanni Uuksulainen
Main aim of cohort, please briefly describe the main objectives of the cohort
  To provide monitoring data on six solvents: styrene, toluene, xylene, tetrachloroethylene, trichlorethylene and 1,1,1-trichloroethane among exposed Finnish workers during 1965-83
Study design (please select as many as appropriate)
 

  • Prospective cohort

Source population (please select as many as appropriate)
 

  • Industry / occupation-based

Inclusion criteria
  Individuals were identified based on availability of biological measurement of six organic solvents analyzed at FIOH during 1965-1983.
Exclusion criteria
  Unknown personal identity code
Enrollment
  Completed
Men at enrollment
  5931
Women at enrollment
  3194
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 

  • Death certificate
  • Use of registers (specify)

Specify: Use of registers
 

  • sickness absence, pensions

3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 

  • Registry-based

Occupational history/time frame
  Current, at enrollment
Occupational coding performed
  Yes
Occupation (specify coding system used)
 

  • ISCO-68

Types of exposure measurements
 

  • Biomarkers (see also section 5)
  • Workplace sampling

Methods for exposure assessment (please select as many as appropriate)
 

  • Job Exposure Matrix
  • Measurements (external sampling, biomarkers)

 

  • FIN-JEM

Main categories
 

  • Solvents

Solvents | Aromatic hydrocarbon solvents
 

  • Styrene and styrene oxide
  • Toluene

Solvents | Chlorinated hydrocarbon solvents
 

  • Trichloroethanes
  • Trichloroethylene

4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 

  • Biomarker (specify)

Follow-up - type of outcome data collected (select more than one if applicable)
 

  • Death certificates
  • Registry-based

Registry-based
 

  • Cancer incidence
  • Employment status
  • Mortality register

Outcome type (please select as many as appropriate)
 

  • Mortality
  • Morbidity
  • Disability

Diagnostic groups based on ICD10
 

  • C + D Neoplasms
  • E Metabolism disease
  • F Mental disorders
  • G Disease in the nervous system
  • I Heart disease
  • I Cerebrovascular diseases
  • J Respiratory disease
  • M Arthritis, arthrosis, systemic connective disorders, spine disorders
  • M Disorders of muscles, bones, synovialis, bursa, cartilage
  • O+P Pregnancy and labour

C + D Neoplasms
 

  • Benign neoplasm
  • Carcinoma in situ
  • Leukemia
  • Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
  • Malignant neoplasm lung
  • Mesothelioma
  • Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
  • Malignant neoplasm of bone and articular cartilage
  • Melanoma and other malignant neoplasms of skin
  • Neoplasms connective and soft tissue including nerves
  • Malignant neoplasm of breast
  • Malignant neoplasms, females gynecological
  • Malignant neoplasms of male genital organs
  • Malignant neoplasm of urinary tract and kidney
  • Malignant neoplasms of eye, brain and other parts of central nervous system
  • Malignant neoplasms of thyroid and other endocrine glands
  • Malignant neoplasms of ill-defined, secondary and unspecified sites
  • Malignant neoplasm without specification of site including excl. leukemia
  • Other, please state

5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 

  • Blood
  • Urine

6. Other Information
 

  • Demographics
  • Education

Possibility for linkage to data registries/data enrichment via data linkage
 

  • Cancer incidence
  • Employment status
  • Mortality register
  • Other (specify)

Specify: Other
  sickness absence, pensions