2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   NOCCA Country   Denmark Finland Iceland Norway Sweden Please provide any other information on the cohort location/s if needed   Nordic countries Name   Sanna Heikkinen Institution   Finnish Cancer Registry Email   sanna.heikkinen@cancer.fi Phone   +358504416638 Do you want to add another Principal Investigator of the Cohort   Add another Principal Investigator of the cohort Name   Ingrid Sivesind Mehlum Institution   STAMI Email   ism@stami.no Phone   +4723195327 Do you want to add another Principal Investigator of the Cohort   Add another Principal Investigator of the cohort Name   Johnni Hansen Institution   Danish Cancer Society Email   johnni@cancer.dk Phone   +4535257640 Website   https://astra.cancer.fi/NOCCA/ Name of committee   According to national regulations Upload files   Occupation-and-cancer-follow-up-of-15-million-people-in-five-Nordic-countries.pdf Or provide website   Other publications: https://astra.cancer.fi/NOCCA/studies.html Contact Principal Investigator (name)   Sanna Heikkinen Data access policy (briefly describe)   Principles for use of data from NOCCA All external suggestions for topics of analysis / specific papers shall be handed to NOCCA principle investigator (PI) of any Nordic country, in the form of a short study application, as specified below. If the application is formally acceptable, it will be distributed to all other PIs of the Nordic countries. If the study requires use of the NOCCA Job Exposure Matrix, the application will also be forwarded to the NOCCA JEM Team. If the suggested topic has not been assigned to some other persons, and if the PIs judge that the proposed study is feasible and worth doing, the data can be used by the applicant inside or outside the NOCCA group upon signature of a data transfer agreement, to be signed by each national PI. Each country is free to opt out of any study. The short research protocol should include: The hypothesis and specific aims of the study, The list of variables to be used, The analytical strategy (analysis plan), The persons responsible for data management, data analysis and other tasks related to the preparation of the manuscript, Timetable for use of the data (after which the access to the data will no longer be allowed and the research topic may be transferred to some other research team; the timeline is important to guarantee that important study topics will really be progressing) a publication plan, including proposed authors and order of authors The costs of the study and the provenience of funds to cover the study costs, Possible conflicts of interest related to the person/group requesting the use of the data (for example affiliation with or funding received from specific industries for the specific study or other related topics). Please note that costs to cover the data management and preparation may be charged to the individual/group requesting use of the data. At least one representative of each participating country should be included in the publications. If the study requires use of the NOCCA Job Exposure Matrix, at least one of the JEM Team should be on the list of authors. If separate permissions by ethical or data inspection board need to updated for a specific article, they are under responsibility of the applicant in collaboration with the country NOCCA PI. Is this cohort part of a consortium? (name consortium)   NOCCA Upload files   Principles-for-use-of-data-from-NOCCA.docx Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Main aim of cohort, please briefly describe the main objectives of the cohort   To present up to 60 years of cancer incidence data by occupational category for the Nordic populations. Further studies will focus on associations between specific work-related factors and well-defined cancer diseases with the aim to identify exposure-response patterns. In addition to the cancer data demonstrated in the incidence publication, the NOCCA project produces a Nordic Job Exposure Matrix (JEM) that transforms information about occupational title histories to quantitative estimates of specific exposures. The third essential component is methodological development targeted at better interpretation of results based on averaged information of exposures and co-factors in the occupational categories. Study design (please select as many as appropriate)   Prospective cohort Retrospective cohort Nested case-control / Case-cohort Source population (please select as many as appropriate)   General population: International General population: National Generation (parents-children) study Comparators (please select as many as appropriate)   Internal study population External study population (includes SMR/SIR studies) Inclusion criteria   Entire population at working age Exclusion criteria   None Enrollment   Completed Age range at entry (main cohort)   Minimum Maximum Mean 30 64 Men at enrollment   15 000 000 Women at enrollment   15 000 000 Children (<18 years) at enrollment   None Participation rate at enrollment (if known)   98 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Disease incidence records Use of registers (specify) Disease incidence records (specify)   Cancer registries Specify: Use of registers   Information on incident cancers from the cancer registries First follow-up period (provide year)   1961 Last follow-up period (provide year)   2021 Number of follow-ups after baseline (provide number)   Continuous follow-up 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Questionnaire, Personal (Self-reporting or interview) Job-employment records Registry-based Occupational history/time frame   Lifetime Occupational coding performed   Yes Occupation (specify coding system used)   NYK (based on ISCO 58), ISCO 88, ISCO 08 Methods for exposure assessment (please select as many as appropriate)   Job Exposure Matrix   FIN-JEM Please insert reference/further information   Kauppinen T, Uuksulainen S, Saalo A, Mäkinen I, Pukkala E. Use of the Finnish Information System on Occupational Exposure (FINJEM) in epidemiologic, surveillance, and other applications. Ann Occup Hyg. 2014 Apr;58(3):380-96. doi: 10.1093/annhyg/met074. Epub 2014 Jan 8. PMID: 24401793.   NOCCA JEM Please insert reference/further information   Kauppinen T, Heikkilä P, Plato N, Woldbaek T, Lenvik K, Hansen J, Kristjansson V, Pukkala E. Construction of job-exposure matrices for the Nordic Occupational Cancer Study (NOCCA). Acta Oncol. 2009;48(5):791-800. doi: 10.1080/02841860902718747. PMID: 19225948. Main categories   Dusts and fibres Solvents Pesticides Metals and metal oxides Other chemicals Engineered nanoparticles Biological factors Physical agents Ergonomics, physical workload, and injury related Psychosocial domains Dusts and fibres | Fibres   Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material) Dusts and fibres | Inorganic dusts   Quartz (quartz or crystalline silica containing dusts) Dusts and fibres | Organic dusts   Animal dust (from living animals or hairs of animals, e.g. raw wool, furs of minks, etc.) Flour dust Wood dust (not specified) Solvents | Aliphatic and alicyclic hydrocarbon solvents   Gasoline Other (specify) Solvents | Aliphatic and alicyclic hydrocarbon solvents | Specify: Other   Not specified Solvents | Aromatic hydrocarbon solvents   Benzene Styrene and styrene oxide Toluene Other (specify) Solvents | Aromatic hydrocarbon solvents | Specify: Other   Not specified Solvents | Chlorinated hydrocarbon solvents   Methylene chloride Perchloroethylene Trichloroethanes Trichloroethylene Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated   Formaldehyde Metals and metal oxides   Chromium (metallic chromium, Cr(iii), Cr(vi) and all compounds) Iron (metallic iron and all compounds) Lead and all compounds Nickel and all compounds Other chemicals | Engine exhaust   Diesel engine exhaust Other chemicals | Polycyclic aromatic hydrocarbons (PAHs)   Benzo(a)pyrene Bitumen fumes Other chemicals | Sulphur compounds, volatile   Sulphur dioxide and sulphur trioxide Other chemicals | Welding fumes   Welding fumes, not specified Engineered nanoparticles   Other (specify) Engineered nanoparticles | Specify: Other   Not specified Physical agents   Light-at-night (LAN) Noise Radiation Physical agents | Radiation   Ionising Solar and ultraviolet Other   Other Specify: Other   EMF Ergonomics, physical workload, and injury related   Physical work load (e.g. heavy lifting of people or objects, pushing/pulling) Sedentary work Comments   Other exposure categories have been added to NOCCA-JEM and can be included if needed (e.g. some lifestyle factors at an aggregate level). 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Registry-based Registry-based   Cancer incidence Follow-up - type of outcome data collected (select more than one if applicable)   Registry-based Registry-based   Cancer incidence Outcome type (please select as many as appropriate)   Morbidity Diagnostic groups based on ICD10   C + D Neoplasms C + D Neoplasms   Benign neoplasm Carcinoma in situ Leukemia Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas Malignant neoplasm lung Mesothelioma Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura Malignant neoplasm of bone and articular cartilage Melanoma and other malignant neoplasms of skin Neoplasms connective and soft tissue including nerves Malignant neoplasm of breast Malignant neoplasms, females gynecological Malignant neoplasms of male genital organs Malignant neoplasm of urinary tract and kidney Malignant neoplasms of eye, brain and other parts of central nervous system Malignant neoplasms of thyroid and other endocrine glands Malignant neoplasms of ill-defined, secondary and unspecified sites Malignant neoplasm without specification of site including excl. leukemia Other, please state 6. Other Information   Alcohol Anthropometry Physical exercise Socioeconomic status Smoking Other (specify) Specify: Other   Smoking, alcohol, BMI and physical activity at an aggregate level from survey data Possibility for linkage to data registries/data enrichment via data linkage   Birth register Cancer incidence Disease specific clinical database Employment status Hospital discharge Medication usage Migration Mortality register Other (specify) Specify: Other   All registries with a possibility to link with a personal ID code, with relevant permissions. Please describe plans that are funded or most likely to be funded   We are currently working on an update on the previous publication from 2009: Occupation and cancer – follow-up of 15 million people in five Nordic countries (https://doi.org/10.1080/02841860902913546).