1. IDENTIFICATION & BASIC DESCRIPTION |
Cohort name
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NOCCA
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Country
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- Denmark
- Finland
- Iceland
- Norway
- Sweden
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Please provide any other information on the cohort location/s if needed
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Nordic countries
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Name
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Sanna Heikkinen
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Institution
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Finnish Cancer Registry
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Email
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sanna.heikkinen@cancer.fi
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Phone
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+358504416638
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Ingrid Sivesind Mehlum
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Institution
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STAMI
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Email
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ism@stami.no
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Phone
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+4723195327
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Do you want to add another Principal Investigator of the Cohort
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- Add another Principal Investigator of the cohort
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Name
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Johnni Hansen
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Institution
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Danish Cancer Society
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Email
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johnni@cancer.dk
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Phone
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+4535257640
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Website
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- https://astra.cancer.fi/NOCCA/
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Name of committee
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According to national regulations
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Upload files
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Or provide website
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- Other publications: https://astra.cancer.fi/NOCCA/studies.html
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Contact Principal Investigator (name)
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Sanna Heikkinen
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Data access policy (briefly describe)
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Principles for use of data from NOCCA All external suggestions for topics of analysis / specific papers shall be handed to NOCCA principle investigator (PI) of any Nordic country, in the form of a short study application, as specified below. If the application is formally acceptable, it will be distributed to all other PIs of the Nordic countries. If the study requires use of the NOCCA Job Exposure Matrix, the application will also be forwarded to the NOCCA JEM Team. If the suggested topic has not been assigned to some other persons, and if the PIs judge that the proposed study is feasible and worth doing, the data can be used by the applicant inside or outside the NOCCA group upon signature of a data transfer agreement, to be signed by each national PI. Each country is free to opt out of any study. The short research protocol should include: The hypothesis and specific aims of the study, The list of variables to be used, The analytical strategy (analysis plan), The persons responsible for data management, data analysis and other tasks related to the preparation of the manuscript, Timetable for use of the data (after which the access to the data will no longer be allowed and the research topic may be transferred to some other research team; the timeline is important to guarantee that important study topics will really be progressing) a publication plan, including proposed authors and order of authors The costs of the study and the provenience of funds to cover the study costs, Possible conflicts of interest related to the person/group requesting the use of the data (for example affiliation with or funding received from specific industries for the specific study or other related topics). Please note that costs to cover the data management and preparation may be charged to the individual/group requesting use of the data. At least one representative of each participating country should be included in the publications. If the study requires use of the NOCCA Job Exposure Matrix, at least one of the JEM Team should be on the list of authors. If separate permissions by ethical or data inspection board need to updated for a specific article, they are under responsibility of the applicant in collaboration with the country NOCCA PI.
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Is this cohort part of a consortium? (name consortium)
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NOCCA
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Upload files
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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To present up to 60 years of cancer incidence data by occupational category for the Nordic populations. Further studies will focus on associations between specific work-related factors and well-defined cancer diseases with the aim to identify exposure-response patterns. In addition to the cancer data demonstrated in the incidence publication, the NOCCA project produces a Nordic Job Exposure Matrix (JEM) that transforms information about occupational title histories to quantitative estimates of specific exposures. The third essential component is methodological development targeted at better interpretation of results based on averaged information of exposures and co-factors in the occupational categories.
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Study design (please select as many as appropriate)
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- Prospective cohort
- Retrospective cohort
- Nested case-control / Case-cohort
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Source population (please select as many as appropriate)
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- General population: International
- General population: National
- Generation (parents-children) study
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Comparators (please select as many as appropriate)
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- Internal study population
- External study population (includes SMR/SIR studies)
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Inclusion criteria
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Entire population at working age
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Exclusion criteria
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None
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Enrollment
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Completed
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Age range at entry (main cohort)
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Minimum |
Maximum |
Mean |
30 |
64 |
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Men at enrollment
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15 000 000
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Women at enrollment
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15 000 000
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Children (<18 years) at enrollment
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None
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Participation rate at enrollment (if known)
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98
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2. OUTCOME FOLLOW-UP |
Type of data for outcome follow-up (please select as many as appropriate)
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- Disease incidence records
- Use of registers (specify)
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Disease incidence records (specify)
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Specify: Use of registers
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- Information on incident cancers from the cancer registries
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First follow-up period (provide year)
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1961
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Last follow-up period (provide year)
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2021
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Number of follow-ups after baseline (provide number)
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Continuous follow-up
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3. OCCUPATIONAL EXPOSURES |
Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Job-employment records
- Registry-based
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Occupational history/time frame
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Lifetime
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Occupational coding performed
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Yes
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Occupation (specify coding system used)
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- NYK (based on ISCO 58), ISCO 88, ISCO 08
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Methods for exposure assessment (please select as many as appropriate)
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Please insert reference/further information
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Kauppinen T, Uuksulainen S, Saalo A, Mäkinen I, Pukkala E. Use of the Finnish Information System on Occupational Exposure (FINJEM) in epidemiologic, surveillance, and other applications. Ann Occup Hyg. 2014 Apr;58(3):380-96. doi: 10.1093/annhyg/met074. Epub 2014 Jan 8. PMID: 24401793.
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Please insert reference/further information
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Kauppinen T, Heikkilä P, Plato N, Woldbaek T, Lenvik K, Hansen J, Kristjansson V, Pukkala E. Construction of job-exposure matrices for the Nordic Occupational Cancer Study (NOCCA). Acta Oncol. 2009;48(5):791-800. doi: 10.1080/02841860902718747. PMID: 19225948.
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Main categories
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- Dusts and fibres
- Solvents
- Pesticides
- Metals and metal oxides
- Other chemicals
- Engineered nanoparticles
- Biological factors
- Physical agents
- Ergonomics, physical workload, and injury related
- Psychosocial domains
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Dusts and fibres | Fibres
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- Asbestos (any form of asbestos chrysotile, crocidolite, tremolite, anthophyllite, etc. or asbestos-containing material)
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Dusts and fibres | Inorganic dusts
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- Quartz (quartz or crystalline silica containing dusts)
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Dusts and fibres | Organic dusts
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- Animal dust (from living animals or hairs of animals, e.g. raw wool, furs of minks, etc.)
- Flour dust
- Wood dust (not specified)
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Solvents | Aliphatic and alicyclic hydrocarbon solvents
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Solvents | Aliphatic and alicyclic hydrocarbon solvents | Specify: Other
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Not specified
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Solvents | Aromatic hydrocarbon solvents
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- Benzene
- Styrene and styrene oxide
- Toluene
- Other (specify)
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Solvents | Aromatic hydrocarbon solvents | Specify: Other
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Not specified
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Solvents | Chlorinated hydrocarbon solvents
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- Methylene chloride
- Perchloroethylene
- Trichloroethanes
- Trichloroethylene
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Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated
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Metals and metal oxides
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- Chromium (metallic chromium, Cr(iii), Cr(vi) and all compounds)
- Iron (metallic iron and all compounds)
- Lead and all compounds
- Nickel and all compounds
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Other chemicals | Engine exhaust
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Other chemicals | Polycyclic aromatic hydrocarbons (PAHs)
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- Benzo(a)pyrene
- Bitumen fumes
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Other chemicals | Sulphur compounds, volatile
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- Sulphur dioxide and sulphur trioxide
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Other chemicals | Welding fumes
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- Welding fumes, not specified
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Engineered nanoparticles
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Engineered nanoparticles | Specify: Other
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Not specified
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Physical agents
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- Light-at-night (LAN)
- Noise
- Radiation
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Physical agents | Radiation
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- Ionising
- Solar and ultraviolet
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Other
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Specify: Other
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EMF
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Ergonomics, physical workload, and injury related
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- Physical work load (e.g. heavy lifting of people or objects, pushing/pulling)
- Sedentary work
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Comments
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Other exposure categories have been added to NOCCA-JEM and can be included if needed (e.g. some lifestyle factors at an aggregate level).
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4. OUTCOMES EVALUATED |
Baseline - type of outcome data collected (select more than one if applicable)
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Registry-based
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Follow-up - type of outcome data collected (select more than one if applicable)
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Registry-based
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Outcome type (please select as many as appropriate)
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Diagnostic groups based on ICD10
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C + D Neoplasms
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- Benign neoplasm
- Carcinoma in situ
- Leukemia
- Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas
- Malignant neoplasm lung
- Mesothelioma
- Other malignant neoplasm of respiratory and intrathoracic organs, heart, pleura
- Malignant neoplasm of bone and articular cartilage
- Melanoma and other malignant neoplasms of skin
- Neoplasms connective and soft tissue including nerves
- Malignant neoplasm of breast
- Malignant neoplasms, females gynecological
- Malignant neoplasms of male genital organs
- Malignant neoplasm of urinary tract and kidney
- Malignant neoplasms of eye, brain and other parts of central nervous system
- Malignant neoplasms of thyroid and other endocrine glands
- Malignant neoplasms of ill-defined, secondary and unspecified sites
- Malignant neoplasm without specification of site including excl. leukemia
- Other, please state
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6. Other Information |
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- Alcohol
- Anthropometry
- Physical exercise
- Socioeconomic status
- Smoking
- Other (specify)
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Specify: Other
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Smoking, alcohol, BMI and physical activity at an aggregate level from survey data
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Possibility for linkage to data registries/data enrichment via data linkage
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- Birth register
- Cancer incidence
- Disease specific clinical database
- Employment status
- Hospital discharge
- Medication usage
- Migration
- Mortality register
- Other (specify)
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Specify: Other
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All registries with a possibility to link with a personal ID code, with relevant permissions.
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Please describe plans that are funded or most likely to be funded
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We are currently working on an update on the previous publication from 2009: Occupation and cancer – follow-up of 15 million people in five Nordic countries (https://doi.org/10.1080/02841860902913546).
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