2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   Biology, Affect, Stress, Imaging and Cognition (BASIC) Country   Sweden Please provide any other information on the cohort location/s if needed   Uppsala Name   Alkistis Skalkidou Institution   Uppsala University Email   alkistis.skalkidou@kbh.uu.se Phone   +4618-611 5679 Website   https://www.basicstudie.se/ Name of committee   Regional Ethical Review Board in Uppsala (Reference number 2009/171) Upload files   Characteristics-of-women-with-different-perinatal-depression-trajectories.pdf BASIC-protocol.pdf Contact Principal Investigator (name)   Alkistis Skalkidou Data access policy (briefly describe)   Researchers need to contact the principal investigator for data access Is this cohort part of a consortium? (name consortium)   International Postpartum depression: Action towards Causes and Treatment (PACT); Birth Cohorts Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Main aim of cohort, please briefly describe the main objectives of the cohort   The purpose of the BASIC study is to enrich and expand our knowledge on the pathophysiological processes underlying perinatal depression (PND) and also to pinpoint both epidemiological and biolog-ical predictors of the disease in order to improve early detection. Study design (please select as many as appropriate)   Prospective cohort Source population (please select as many as appropriate)   Mother-child cohort Comparators (please select as many as appropriate)   Internal study population Inclusion criteria   Being pregnant Exclusion criteria   1)age below 18 years, 2)insufficient ability to read and understand Swedish,3) protected identity, 4) known bloodborne infections and/or 5) non-viable pregnancy as diagnosed by routine ultrasound. Enrollment   Completed Age range at entry (main cohort)   Minimum Maximum Mean 18 48 31.5 Age range at entry (subcohort)   Minimum Maximum Mean Please describe 19 44 31 Nested case–control group 18 48 33 Elective caesarean subgroup 19 48 31 Cortisol subgroups Men at enrollment   N/A Women at enrollment   6478 pregnancies Children (<18 years) at enrollment   N/A Men at last follow-up   N/A Women at last follow-up   3845 Children (<18 years) at last follow-up   N/A Participation rate at enrollment (if known)   20 Comments   Between September 2009 and November 2018, women during 31 687 pregnancies have been invited to the study. In 6478 of these pregnancies, the women chose to participate (consent rate 20.4%). 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Active (contact with participants) Hospital / physician diagnoses Use of registers (specify) Active (contact with participants) (specify)   Internet-based surveys are sent to all participants at baseline, at gestational week 32, and post-partum at 6weeks, 6months and 12 months. Biological samples are collected at several of these points and at childbirth. Hospital / Physician diagnoses (specify)   information provided from medical journals Specify: Use of registers   Perinatal health information, especially regarding childbirth, is gathered continuously through linkage to medical journals. Data from national health registers. First follow-up period (provide year)   14-16 weeks after baseline Last follow-up period (provide year)   1 year after birth Number of follow-ups after baseline (provide number)   4 Participation at last follow-up (if known)   71 Comments   82% of the participants who were included at baseline provided data after 14-16 weeks. The follow-up rate is 83.7% at 6 weeks postpartum, 77.7% at 6 months postpartum and 59.4% at the last follow-up at 12 months. 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Questionnaire, Personal (Self-reporting or interview) Registry-based Occupational history/time frame   Current, at enrollment Occupational coding performed   No 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Death certificates Medical records Questionnaire, individual (self-recording or interview) Registry-based Registry-based   Birth register Disease specific clinical database Employment status Hospital discharge Medication usage Mortality register Migration Follow-up - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Clinical/functional evaluation, e.g. spirometry, ECGs (specify) Medical records Questionnaire, individual (self-recording or interview) Registry-based Specify: Clinical/functional evaluation, e.g. spirometry, ECGs   HRV, bioimpedance, blood pressure Specify: Biomarker   inflammatory biomarkers, cortisol, genome, metabolomic Registry-based   Birth register Disease specific clinical database Employment status Hospital discharge Medication usage Mortality register Migration Outcome type (please select as many as appropriate)   Morbidity Disability Diagnostic groups based on ICD10   F Mental disorders O+P Pregnancy and labour F Mental disorders   Mood [affective] disorders Depression O+P Pregnancy and labour   Eclampsia in pregnancy, labour or puerperium Complications of labour and delivery Preterm delivery Extremely low birth weight Other low birth weight Exceptionally large baby Birth trauma Other health related outcomes   Biomarkers Lifestyle change Quality of life/wellbeing Sickness absence Sleep 5. BIOLOGICAL SAMPLES & ANALYSIS Biological samples collected   Blood Other Specify: Other   umbilical cord biopsy, placental biopsy, amniotic fluid, microbiota samples, cerebrospinal fluid, Biological processing   DNA RNA Genetic and other lab analyses   Biomarkers (specify) Epigenomics Genomics / GWAS Genomics / Other genetics (specify) Metabolomics Specify: Biomarkers   inflammatory analyses Specify: Other genetics   single nucleotide polymorphism 6. Other Information   Alcohol Diet Education Medical history Personality Physical exercise Residential history Socioeconomic status Smoking Possibility for linkage to data registries/data enrichment via data linkage   Birth register Disease specific clinical database Employment status Hospital discharge Medication usage Migration Mortality register