1. IDENTIFICATION & BASIC DESCRIPTION
Cohort name
  Biology, Affect, Stress, Imaging and Cognition (BASIC)
Country
 
  • Sweden
Please provide any other information on the cohort location/s if needed
  Uppsala
Name
  Alkistis Skalkidou
Institution
  Uppsala University
Email
  alkistis.skalkidou@kbh.uu.se
Phone
  +4618-611 5679
Website
 
  • https://www.basicstudie.se/
Name of committee
  Regional Ethical Review Board in Uppsala (Reference number 2009/171)
Upload files
 
Contact Principal Investigator (name)
  Alkistis Skalkidou
Data access policy (briefly describe)
  Researchers need to contact the principal investigator for data access
Is this cohort part of a consortium? (name consortium)
  International Postpartum depression: Action towards Causes and Treatment (PACT); Birth Cohorts
Participation in pooled analyses
 
  • The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
Main aim of cohort, please briefly describe the main objectives of the cohort
  The purpose of the BASIC study is to enrich and expand our knowledge on the pathophysiological processes underlying perinatal depression (PND) and also to pinpoint both epidemiological and biolog-ical predictors of the disease in order to improve early detection.
Study design (please select as many as appropriate)
 
  • Prospective cohort
Source population (please select as many as appropriate)
 
  • Mother-child cohort
Comparators (please select as many as appropriate)
 
  • Internal study population
Inclusion criteria
  Being pregnant
Exclusion criteria
  1)age below 18 years, 2)insufficient ability to read and understand Swedish,3) protected identity, 4) known bloodborne infections and/or 5) non-viable pregnancy as diagnosed by routine ultrasound.
Enrollment
  Completed
Age range at entry (main cohort)
 
Minimum Maximum Mean
18 48 31.5
Age range at entry (subcohort)
 
Minimum Maximum Mean Please describe
19 44 31 Nested case–control group
18 48 33 Elective caesarean subgroup
19 48 31 Cortisol subgroups
Men at enrollment
  N/A
Women at enrollment
  6478 pregnancies
Children (<18 years) at enrollment
  N/A
Men at last follow-up
  N/A
Women at last follow-up
  3845
Children (<18 years) at last follow-up
  N/A
Participation rate at enrollment (if known)
  20
Comments
  Between September 2009 and November 2018, women during 31 687 pregnancies have been invited to the study. In 6478 of these pregnancies, the women chose to participate (consent rate 20.4%).
2. OUTCOME FOLLOW-UP
Type of data for outcome follow-up (please select as many as appropriate)
 
  • Active (contact with participants)
  • Hospital / physician diagnoses
  • Use of registers (specify)
Active (contact with participants) (specify)
 
  • Internet-based surveys are sent to all participants at baseline, at gestational week 32, and post-partum at 6weeks, 6months and 12 months. Biological samples are collected at several of these points and at childbirth.
Hospital / Physician diagnoses (specify)
 
  • information provided from medical journals
Specify: Use of registers
 
  • Perinatal health information, especially regarding childbirth, is gathered continuously through linkage to medical journals. Data from national health registers.
First follow-up period (provide year)
  14-16 weeks after baseline
Last follow-up period (provide year)
  1 year after birth
Number of follow-ups after baseline (provide number)
  4
Participation at last follow-up (if known)
  71
Comments
  82% of the participants who were included at baseline provided data after 14-16 weeks. The follow-up rate is 83.7% at 6 weeks postpartum, 77.7% at 6 months postpartum and 59.4% at the last follow-up at 12 months.
3. OCCUPATIONAL EXPOSURES
Source of exposure data collected (please select as many as appropriate)
 
  • Questionnaire, Personal (Self-reporting or interview)
  • Registry-based
Occupational history/time frame
  Current, at enrollment
Occupational coding performed
  No
4. OUTCOMES EVALUATED
Baseline - type of outcome data collected (select more than one if applicable)
 
  • Death certificates
  • Medical records
  • Questionnaire, individual (self-recording or interview)
  • Registry-based
Registry-based
 
  • Birth register
  • Disease specific clinical database
  • Employment status
  • Hospital discharge
  • Medication usage
  • Mortality register
  • Migration
Follow-up - type of outcome data collected (select more than one if applicable)
 
  • Biomarker (specify)
  • Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
  • Medical records
  • Questionnaire, individual (self-recording or interview)
  • Registry-based
Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
  HRV, bioimpedance, blood pressure
Specify: Biomarker
  inflammatory biomarkers, cortisol, genome, metabolomic
Registry-based
 
  • Birth register
  • Disease specific clinical database
  • Employment status
  • Hospital discharge
  • Medication usage
  • Mortality register
  • Migration
Outcome type (please select as many as appropriate)
 
  • Morbidity
  • Disability
Diagnostic groups based on ICD10
 
  • F Mental disorders
  • O+P Pregnancy and labour
F Mental disorders
 
  • Mood [affective] disorders
  • Depression
O+P Pregnancy and labour
 
  • Eclampsia in pregnancy, labour or puerperium
  • Complications of labour and delivery
  • Preterm delivery
  • Extremely low birth weight
  • Other low birth weight
  • Exceptionally large baby
  • Birth trauma
Other health related outcomes
 
  • Biomarkers
  • Lifestyle change
  • Quality of life/wellbeing
  • Sickness absence
  • Sleep
5. BIOLOGICAL SAMPLES & ANALYSIS
Biological samples collected
 
  • Blood
  • Other
Specify: Other
  umbilical cord biopsy, placental biopsy, amniotic fluid, microbiota samples, cerebrospinal fluid,
Biological processing
 
  • DNA
  • RNA
Genetic and other lab analyses
 
  • Biomarkers (specify)
  • Epigenomics
  • Genomics / GWAS
  • Genomics / Other genetics (specify)
  • Metabolomics
Specify: Biomarkers
  inflammatory analyses
Specify: Other genetics
  single nucleotide polymorphism
6. Other Information
 
  • Alcohol
  • Diet
  • Education
  • Medical history
  • Personality
  • Physical exercise
  • Residential history
  • Socioeconomic status
  • Smoking
Possibility for linkage to data registries/data enrichment via data linkage
 
  • Birth register
  • Disease specific clinical database
  • Employment status
  • Hospital discharge
  • Medication usage
  • Migration
  • Mortality register