2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   INUENDO Country   Albania Greenland Poland Sweden Ukraine Name   Gunnar Toft Institution   Aarhus University Hospital Email   guntof@rm.dk Upload files   1476-069X-4-26.pdf Contact Principal Investigator (name)   Gunnar Toft Data access policy (briefly describe)   Approval from all data collecting centers and data transfer agreeement is needed Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Main aim of cohort, please briefly describe the main objectives of the cohort   To study the effects of exposure to persistent organic pollutants on male and female fertility Study design (please select as many as appropriate)   Prospective cohort Source population (please select as many as appropriate)   General population: International Mother-child cohort Comparators (please select as many as appropriate)   Internal study population Inclusion criteria   Pregnant women, >18 years of age, + husbands/spouses Enrollment   Completed Age range at entry (main cohort)   Minimum Maximum Mean 18 64 30 Men at enrollment   797 Women at enrollment   2269 Children (<18 years) at enrollment   0 Children (<18 years) at last follow-up   1109 Participation rate at enrollment (if known)   43 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Active (contact with participants) Active (contact with participants) (specify)   Follow up on childhood growth and development at 6-9 years of age 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Questionnaire, Personal (Self-reporting or interview) Questionnaire, Personal (Occupational/industry modules) Industry-based questionnaire Occupational history/time frame   Current, at enrollment Occupational coding performed   Yes Occupation (specify coding system used)   ISCO Industry (specify coding system used)   NACE Methods for exposure assessment (please select as many as appropriate)   Self-report Main categories   Pesticides Metals and metal oxides Other chemicals Pesticides | Insecticides   DDT Metals and metal oxides   Cadmium and all compounds Lead and all compounds Mercury, organic, inorganic Other chemicals | Flame retardants   Flame retardants Other chemicals | Per- and polyfluoroalkyl substances (PFAS)   Per- and polyfluoroalkyl substances (PFAS) Other chemicals | Phthalates   Phthalates Other chemicals | PCBs   PCBs (polychlorinated biphenyls) 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Questionnaire, individual (self-recording or interview) Follow-up - type of outcome data collected (select more than one if applicable)   Questionnaire, individual (self-recording or interview) Outcome type (please select as many as appropriate)   Morbidity Disability Diagnostic groups based on ICD10   E Malnutrition and obesity F Mental disorders N Male and female related disorders O+P Pregnancy and labour Q After birth – child disorders E Malnutrition and obesity   Obesity F Mental disorders   Personality and behavioural disorders Disorders of psychological development including autism and Aspergers syndrome N Male and female related disorders   Male infertility Abnormal menstrual cycle Female infertility Spontaneous abortion O+P Pregnancy and labour   Preterm delivery Other low birth weight Exceptionally large baby 5. BIOLOGICAL SAMPLES & ANALYSIS Biological samples collected   Blood Other Specify: Other   Buccal swabs Biological processing   DNA 6. Other Information   Alcohol Anthropometry Demographics Diet Education Environmental other (specify) Medical history Socioeconomic status Smoking Specify: Environmental other   Biomarker measurements of environmental exposures as previously pecified