2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   PERSIAN Birth Cohort Country   Iran Please provide any other information on the cohort location/s if needed   It is conducted in five cities in Iran Name   Roya Kelishadi Institution   Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences Email   roya.kelishadi@gmail.com Phone   +989131161496 Personal website   http://profiles.mui.ac.ir/roya -kelishadi Website   persian-bc.family Name of committee   Isfahan University of Medical Sciences Upload files   PERSIAN-Birth-Cohort-profile.pdf Or provide website   https://www.ingentaconnect.com/content/bup/llcs/2021/00000012/00000002;jsessionid=20d2655asqa50.x-ic-live-02 Contact Principal Investigator (name)   Roya Kelishadi Data access policy (briefly describe)   Data will be shared after receiving proposals and obtaining the confirmation of the Steering committee Is this cohort part of a consortium? (name consortium)   Birth Cohort Consortium of Asia (Bicca) Participation in pooled analyses   The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses). Main aim of cohort, please briefly describe the main objectives of the cohort   The main objective of the PERSIAN Birth Cohort is to evaluate the effects of socio-economic characteristics, lifestyle, diet and environmental exposures, as well as genetic and epigenetic factors, on • different periods of periconception and early life • pregnancy complications and outcomes • mother and child mental and physical health and well-being • child neurodevelopment • early- and late-onset of risk factors for chronic NCDs. We also aim to assess how early life stimuli and exposures over the life course would lead to epigenetic variations Study design (please select as many as appropriate)   Prospective cohort Source population (please select as many as appropriate)   Mother-child cohort Comparators (please select as many as appropriate)   Internal study population External study population (includes SMR/SIR studies) Inclusion criteria   Iranian pregnant mothers and their newborns Exclusion criteria   Non compliance of participants Enrollment   Completed Men at enrollment   10000 Women at enrollment   10000 Children (<18 years) at enrollment   10000 Comments   Information will be completed after data management. 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Active (contact with participants) First follow-up period (provide year)   2017 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Questionnaire, Personal (Self-reporting or interview) Occupational history/time frame   Longest Occupational coding performed   Yes Types of exposure measurements   Biomarkers (see also section 5) Personal external sampling Methods for exposure assessment (please select as many as appropriate)   Data modelling GIS (other spatial methods) Expert assessment Measurements (external sampling, biomarkers) Self-report Main categories   Solvents Pesticides Metals and metal oxides Other chemicals Psychosocial domains Organisation of work including working time Solvents | Aliphatic and alicyclic hydrocarbon solvents   Gasoline Solvent naphtha Solvents | Aromatic hydrocarbon solvents   Benzene Solvents | Chlorinated hydrocarbon solvents   Methylene chloride Vinyl chloride Solvents | Organic solvents, other than aliphatic, aromatic and chlorinated   Alcohols Esters Pesticides | Fungicides   Other (specify) Pesticides | Insecticides   Chlorinated, not specified DDT Metals and metal oxides   Aluminium Arsenic all types Cadmium and all compounds Chromium (metallic chromium, Cr(iii), Cr(vi) and all compounds) Lead and all compounds Other chemicals | Carbon monoxide   Carbon monoxide Other chemicals | Detergents and cleaning products   Cleaning products Detergents Other chemicals | Engine exhaust   Diesel engine exhaust Gasoline engine exhaust Other chemicals | Oil mist   Synthetic metal processing or drilling oils or fluids Other chemicals | Phthalates   Phthalates Psychosocial domains | Job task characteristics/organization of work   Job control, autonomy Psychological job demands Social support at work from supervisors Work engagement Organisation of work including working time | Employment conditions   Contract duration Job insecurity Organisation of work including working time | Shift work   Night (permanent or rotating) Rotating (not night) Regular/variable Organisation of work including working time | Working hours   Duration 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Follow-up - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Questionnaire, individual (self-recording or interview) Outcome type (please select as many as appropriate)   Mortality Morbidity Disability Diagnostic groups based on ICD10   A Bacterial infectious disease, type of microorganisms* D Diseases of blood and blood-forming organs excl. leukemia E Endocrinological disease E Malnutrition and obesity E Metabolism disease F Mental disorders G Disease in the nervous system O+P Pregnancy and labour Q After birth – child disorders S Injuries A Bacterial infectious disease, type of microorganisms*   Brucella Salmonella Shigella D Diseases of blood and blood-forming organs excl. leukemia   Aplastic and other anemias Anaemia, unspecified Coagulation defects E Endocrinological disease   Thyroidea Diabetes mellitus Other endocrinological disease E Malnutrition and obesity   Obesity E Metabolism disease   Other, please state F Mental disorders   Dementia Personality and behavioural disorders Schizophrenia Mood [affective] disorders Depression Eating disorders Mental retardation Disorders of psychological development including autism and Aspergers syndrome Other mental disorder, not otherwise specified Other, please state G Disease in the nervous system   Infectious diseases of the central nervous system Other degenerative disorders of nervous system in diseases classified elsewhere Multiple sclerosis Epilepsy Hydrocephalus O+P Pregnancy and labour   Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium Eclampsia in pregnancy, labour or puerperium Excessive vomiting in pregnancy Venous complications in pregnancy Infections of genito-urinary tract in pregnancy Diabetes mellitus in pregnancy Malnutrition in pregnancy Other specified pregnancy-related conditions Complications of labour and delivery Preterm delivery Extremely low birth weight Other low birth weight Exceptionally large baby Birth trauma Congenital viral diseases Foetal death of unspecified cause Other, please state Q After birth – child disorders   Congenital malformations of the nervous system incl. the brain Congenital malformations of the circulatory system Congenital malformations of the respiratory system Cleft lip and cleft palate Congenital malformations of digestive system Congenital malformations of genital organs Congenital malformations of the urinary system Congenital malformations and deformations of the musculoskeletal system Down's syndrome Turner's syndrome Klinefelter's syndrome Other, please state S Injuries   Injuries to the head Injuries to the thorax Injuries to the abdomen, lower back, lumbar spine and pelvis Injuries to the shoulder, arm and fingers Injuries to the hip and thigh Injuries to the knee and lower leg, ankle and foot Other, please state Other health related outcomes   Biomarkers Lifestyle change Organ function (specify) Quality of life/wellbeing Sleep Work participation 5. BIOLOGICAL SAMPLES & ANALYSIS Biological samples collected   Blood Hair Nails Urine Other Specify: Other   Breast milk Biological processing   DNA Genetic and other lab analyses   Biomarkers (specify) Epigenomics Metabolomics 6. Other Information   Alcohol Anthropometry Diet Education Environmental, air pollution Medical history Personality Physical exercise Residential history Socioeconomic status Smoking Possibility for linkage to data registries/data enrichment via data linkage   Birth register Disease specific clinical database Employment status