| 1. IDENTIFICATION & BASIC DESCRIPTION |
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Cohort name
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Grain dust and microbial exposed workers
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Country
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Name
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Anne Straumfors
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Institution
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STAMI
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Email
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anne.straumfors@stami.no
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Phone
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+47 23195338
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Name of committee
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The Regional Ethical Committee of South-East Norway
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Upload files
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Contact Principal Investigator (name)
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Anne Straumfors
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Is this cohort part of a consortium? (name consortium)
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no
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Participation in pooled analyses
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- The cohort is potentially interested in participating in pooled analyses of (European) occupational cohort studies (note pooled analyses also includes remote decentralized analyses that would not require any transfer of primary data as well as meta-analyses).
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Main aim of cohort, please briefly describe the main objectives of the cohort
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Characterize the bioaerosol exposure and exposure-related responses cross-shift
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Study design (please select as many as appropriate)
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- Prospective cohort
- Nested case-control / Case-cohort
- Other
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Specify: Other
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Exposed versus non-exposed workers in a cross-shift design
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Source population (please select as many as appropriate)
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- Industry / occupation-based
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Comparators (please select as many as appropriate)
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- Internal study population
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Inclusion criteria
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Workers at grain elevators and compound feed mills
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Enrollment
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Completed
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Age range at entry (main cohort)
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| Minimum |
Maximum |
Mean |
| 16 |
61 |
41 |
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Age range at entry (subcohort)
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| Minimum |
Maximum |
Mean |
Please describe |
| 21 |
60 |
46 |
unexposed workers |
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Men at enrollment
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94
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Women at enrollment
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10
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Children (<18 years) at enrollment
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2
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| 2. OUTCOME FOLLOW-UP |
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Type of data for outcome follow-up (please select as many as appropriate)
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- Active (contact with participants)
- Other (specify)
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Active (contact with participants) (specify)
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- Present at workplace before work started and after work (cross-shift)
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First follow-up period (provide year)
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cross shift
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Number of follow-ups after baseline (provide number)
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1
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Participation at last follow-up (if known)
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100
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| 3. OCCUPATIONAL EXPOSURES |
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Source of exposure data collected (please select as many as appropriate)
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- Questionnaire, Personal (Self-reporting or interview)
- Environmental samples
- Other (specify)
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Specify: Other
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Personal exposure samples
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Occupational history/time frame
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Current, at enrollment
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Occupational coding performed
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No
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Industry (specify coding system used)
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- Grain industry and animal feed industry
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Types of exposure measurements
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- Biomarkers (see also section 5)
- Personal external sampling
- Workplace sampling
- Other (specify)
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Specify: Other
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Newly settled dust
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Methods for exposure assessment (please select as many as appropriate)
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- Measurements (external sampling, biomarkers)
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Main categories
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- Dusts and fibres
- Biological factors
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Dusts and fibres | Organic dusts
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- Plant dust (includes plants, fruits, vegetables, plant-borne materials such as natural rubber)
- Other (specify)
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Dusts and fibres | Organic dusts | Specify: Other
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Grain dust
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Biological factors | Bacteria
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Biological factors | Bacteria | Specify: Other
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endotoxin, total bacteria counts
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Biological factors | Moulds-fungi
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- Aflatoxins
- Moulds
- Other (specify)
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Biological factors | Moulds-fungi | Specify: Other
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total fungal spore counts, multiple mycotoxins, total mycobiome, 1,3-beta-glucans
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| 4. OUTCOMES EVALUATED |
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Baseline - type of outcome data collected (select more than one if applicable)
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- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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Gas-diffusion (DLCO), spirometry, acoustic rhinometry
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Follow-up - type of outcome data collected (select more than one if applicable)
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- Biomarker (specify)
- Clinical/functional evaluation, e.g. spirometry, ECGs (specify)
- Questionnaire, individual (self-recording or interview)
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Specify: Clinical/functional evaluation, e.g. spirometry, ECGs
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Gas-diffusion (DLCO), spirometry, acoustic rhinometry,
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Specify: Biomarker
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pneumoproteins, inflammatory markers and markers of platelet activation markers of
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Outcome type (please select as many as appropriate)
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Other health related outcomes
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- Biomarkers
- Organ function (specify)
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Specify: Organ function
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lung function
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| 5. BIOLOGICAL SAMPLES & ANALYSIS |
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Biological samples collected
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Biological processing
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Genetic and other lab analyses
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- Biomarkers (specify)
- Epigenomics
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Specify: Biomarkers
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CC16, SPA, SPD, sP-selectin, IL-6, TNF-alpha, sCD40L, fibrinogen, CRP and circulating miRNA
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| 6. Other Information |
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