2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   The Pesticide Exposed Workers Study Country   Australia Name   Malcolm Sim Institution   Monash University Email   Malcolm.Sim@monash.edu Personal website   https://research.monash.edu/en/persons/malcolm-sim Do you want to add another Principal Investigator of the Cohort   Add another Principal Investigator of the cohort Name   Geza Benke Institution   Monash University Email   Geza.Benke@monash.edu Personal website   https://research.monash.edu/en/persons/geza-benke Name   Ewan MacFarlane Institution   Monash University Email   Ewan.MacFarlane@monash.edu Personal website   https://research.monash.edu/en/persons/ewan-macfarlane Website   https://www.monash.edu/medicine/sphpm/coeh/research/pesticide-exposed-workers-study Name of committee   Monash University Human Research Ethics Committee (MUHREC) Or provide website   https://www.monash.edu/medicine/sphpm/coeh/research/pesticide-exposed-workers-study Main aim of cohort, please briefly describe the main objectives of the cohort   To determine the rates of mortality and of cancer incidence in a cohort of pesticide-exposed Australian workers. Study design (please select as many as appropriate)   Retrospective cohort Source population (please select as many as appropriate)   Industry / occupation-based Comparators (please select as many as appropriate)   Internal study population Inclusion criteria   This explores a large cohort of some 13,000 workers who were end-users of pesticides and participated in pesticide biomonitoring programs from the 1960s to the 1990s. Predominantly agricultural workers, this cohort also includes smaller groups of municipal and public utilities workers, and dedicated pest controllers. Linkage to the national cancer and death registries is used in this project to estimate rates of cancers and causes of death in the cohort compared with that of the general population, identifying trends associated with exposure. The cohort will be re-linked to the registries at periodic intervals (eg. five to ten years). Enrollment   Ongoing Age range at entry (main cohort)   Minimum Maximum Mean 18 65 Men at enrollment   11,131 Women at enrollment   1084 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Death certificate Disease incidence records Death certificate (specify)   Linkage to the death registries is used in this project to estimate causes of death in the cohort compared with that of the general population, identifying trends associated with exposure. The cohort will be re-linked to the registries at periodic intervals (eg. five to ten years). Disease incidence records (specify)   Linkage to the national cancer registries is used in this project to estimate rates of cancers in the cohort compared with that of the general population, identifying trends associated with exposure. The cohort will be re-linked to the registries at periodic intervals (eg. five to ten years). First follow-up period (provide year)   5-10 years 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Job-employment records Occupational history/time frame   Current, at enrollment Occupational coding performed   No Methods for exposure assessment (please select as many as appropriate)   Expert assessment Main categories   Pesticides 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Questionnaire, individual (self-recording or interview) Follow-up - type of outcome data collected (select more than one if applicable)   Death certificates Registry-based Registry-based   Cancer incidence Mortality register Outcome type (please select as many as appropriate)   Mortality Diagnostic groups based on ICD10   C + D Neoplasms I Cerebrovascular diseases J Respiratory disease K Diseases of oesophagus, stomach, duodenum and appendix N Kidney, renal pelvis disease C + D Neoplasms   Malignant neoplasms gastro intes. system including liver, gall bladder, pancreas Malignant neoplasm lung Malignant neoplasm of breast Malignant neoplasms of male genital organs Malignant neoplasm of urinary tract and kidney Malignant neoplasms of thyroid and other endocrine glands J Respiratory disease   Chronic obstructive pulmonary disease (COPD) Asthma 6. Other Information   Demographics Smoking Possibility for linkage to data registries/data enrichment via data linkage   Cancer incidence Mortality register