2020

1. IDENTIFICATION & BASIC DESCRIPTION Cohort name   Born in Bradford Country   United Kingdom Please provide any other information on the cohort location/s if needed   Bradford, UK Name   John Wright Institution   Bradford Teaching Hospitals NHS Foundation Trust Email   john.wright@bthft.nhs.uk Phone   01274 36 4279 Personal website   https://borninbradford.nhs.uk/ Website   https://borninbradford.nhs.uk/ Name of committee   Bradford Research Ethics Committee Upload files   Design-and-characteristics-of-a-new-birth-cohort-to-study-the-early-origins-and-ethnic-variation-of-childhood-obesity-the-BiB1000-study.pdf Growing-up-in-Bradford-protocol-for-the-age-7–11-follow-up-of-the-Born-in-Bradford-birth-cohort.pdf Born-in-Bradford-a-cohort-study-of-babies-born-in-Bradford-and-their-parents-Protocol-for-the-recruitment-phase.pdf Cohort-Profile-The-Born-in-Bradford-multi-ethnic-family-cohort-study.pdf Or provide website   https://borninbradford.nhs.uk/research/ Data access policy (briefly describe)   Requests for existing data and biological samples will be reviewed, prioritised and authorised by the BiB Executive Group. The Investigator should complete an outline proforma available on the Born in Bradford website (borninbradford.nhs.uk) and submit to: borninbradford@bthft.nhs.uk Main aim of cohort, please briefly describe the main objectives of the cohort   The cohort was established in 2007 with the broad aims to: describe health and ill health within a multi-ethnic (largely bi-ethnic) economically deprived population; identify modifiable causal pathways that promote well-being or contribute to ill health; develop, design and evaluate interventions to promote health; provide a model for integrating operational, epidemiological and evaluative research into practice within the National Health Service and other health-related systems; and build and strengthen local research capacity in Bradford. Study design (please select as many as appropriate)   Prospective cohort Source population (please select as many as appropriate)   Mother-child cohort Inclusion criteria   All women planning to give birth at the BRI will be eligible for recruitment, regardless of parity. Exclusion criteria   The only exclusion criterion for recruitment of a woman will be if she plans to move away from Bradford before the birth. Enrollment   Completed Age range at entry (subcohort)   Minimum Maximum Mean Please describe 14 49 27 Men at enrollment   3448 Women at enrollment   12453 Children (<18 years) at enrollment   13858 Men at last follow-up   On-going Women at last follow-up   On-going Children (<18 years) at last follow-up   On-going 2. OUTCOME FOLLOW-UP Type of data for outcome follow-up (please select as many as appropriate)   Active (contact with participants) Disease incidence records Hospital / physician diagnoses Comments   Please refer to our study documents on the Born in Bradford webpage (https://borninbradford.nhs.uk/research/study-documents/) for information on data collected and all follow-ups. 3. OCCUPATIONAL EXPOSURES Source of exposure data collected (please select as many as appropriate)   Questionnaire, Personal (Self-reporting or interview) Breath samples Environmental samples Occupational history/time frame   Current, at enrollment Occupational coding performed   Yes Occupation (specify coding system used)   NS-SEC Types of exposure measurements   Biomarkers (see also section 5) Personal external sampling Methods for exposure assessment (please select as many as appropriate)   Data modelling GIS (other spatial methods) Measurements (external sampling, biomarkers) Self-report 4. OUTCOMES EVALUATED Baseline - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Clinical/functional evaluation, e.g. spirometry, ECGs (specify) Medical records Questionnaire, individual (self-recording or interview) Specify: Clinical/functional evaluation, e.g. spirometry, ECGs   Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/ Specify: Biomarker   Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/ Follow-up - type of outcome data collected (select more than one if applicable)   Biomarker (specify) Clinical/functional evaluation, e.g. spirometry, ECGs (specify) Medical records Questionnaire, individual (self-recording or interview) Specify: Clinical/functional evaluation, e.g. spirometry, ECGs   Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/ Specify: Biomarker   Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/ Outcome type (please select as many as appropriate)   Mortality Morbidity Disability Comments   Born in Bradford collects and has data linkage to a wide range of data, including hospital and GP records. Please refer to the Born in Bradford data dictionary for detailed information: https://borninbradford.github.io/datadict/ 5. BIOLOGICAL SAMPLES & ANALYSIS Biological samples collected   Blood Urine Biological processing   DNA Genetic and other lab analyses   Biomarkers (specify) Epigenomics Genomics / GWAS Genomics / Other genetics (specify) Metabolomics Specify: Biomarkers   Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/ Specify: Other genetics   Exome sequencing Comments   Please refer to the Born in Bradford data dictionary: https://borninbradford.github.io/datadict/ 6. Other Information   Alcohol Anthropometry Demographics Diet Education Environmental, air pollution Medical history Physical exercise Residential history Socioeconomic status Smoking Possibility for linkage to data registries/data enrichment via data linkage   Birth register Hospital discharge Medication usage Mortality register